Mechanisms of Cell-Mediated Cytotoxicity II

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Formation of Protein Channels in Target Membranes....Pages 3-21
IgE-Dependent Platelet Cytotoxicity Against Helminths....Pages 23-33
Killing of Gram-Negative Bacteria by Neutrophils: Role of O 2 - Independent System in Intracellular Killing and Evidence of O 2 -Dependent Extracellular Killing....Pages 35-50
Aberrant Oxygen Metabolism in Neoplastic Cells Injured by Cytotoxic Macrophages....Pages 51-63
The Cell Biology of Tumor Cell Capture by Activated Macrophages....Pages 65-74
Destructive Interactions Between Murine Macrophages, Tumor Cells, and Antibodies of the IgG 2a Isotype....Pages 75-80
Front Matter....Pages 81-82
Reorientation of the Golgi Apparatus and the Microtubule Organizing Center: Is it a Means to Polarize Cell-Mediated Cytotoxicity....Pages 83-97
Cytolytic T-Cell Granules: Biochemimcal Properties and Functional Specificity....Pages 99-119
The Role of Cytoplasmic Granules in Cytotoxicity by Large Granular Lymphocytes and Cytotoxic T Lymphocytes....Pages 121-138
A Unified Theory for the Mechanism of the Lethal Hit by Cytotoxic T Lymphocytes (CTL) and Natural Killer (NK) Cells as Defined by Antisera Capable of Blocking the Lethal Hit Stage of Cytotoxicity....Pages 139-160
Human NK Resistant Tumor Cell Lysis is Effected by IL-2 Activated Killer Cells....Pages 161-175
Front Matter....Pages 177-177
Biochemical Characterization of Natural Killer Cytotoxic Factors....Pages 179-191
Both NK Sensitive and Resistant Mycoplasma Free Cell Lines Stimulate Release of NKCF....Pages 193-201
Studies of Human Natural Killer Cytotoxic Factor (NKCF): Characterization and Analysis of its Mode of Action....Pages 203-220
An Investigation of the Role of Soluble Cytotoxic Factors and Reactive Oxygen Intermediates in Lysis by NK Cells....Pages 221-238
Analysis of Sequential Substages of the Natural Killer Cell Lethal Hit....Pages 239-256
The Lipoxygenase Pathway in the Human NK Cell System....Pages 257-270
A Serine Proteinase as a “Trigger” for Human Natural Killer Lymphocyte-Mediated Cytolysis....Pages 271-280
The Mechanism of Leukoregulin Enhancement of Target Cell Susceptibility to NK Cell Mediated Cytotoxicity in Humans....Pages 281-287
Front Matter....Pages 289-289
Lymphocyte Function-Associated Antigens: Regulation of Lymphocyte Adhesions in Vitro and Immunity in Vivo....Pages 291-310
Front Matter....Pages 289-289
The Function of LFA-1 in Cell-Mediated Killing and Adhesion: Studies on Heritable LFA-1, Mac-1 Deficiency and on Lymphoid Cell Self-Aggregation....Pages 311-322
Functional Interactions of LFA-1, T8 and Alloantigen Surface Structures in T-Cell Mediated Cytotoxicity....Pages 323-341
Requirement for LYT-2/3 Molecules on Allospecific Cytolytic T Lymphocyte Clones is Dependent Upon Target Cell Antigen Density....Pages 343-353
Functional Relationships of LYT-2 and LYT-3 Expression and T-Cell Cytotoxicity: A New Model System....Pages 355-364
The Role of the T3 Molecular Complex on Human T Lymphocyte-Mediated Cytotoxicity....Pages 365-385
The Plasma Membrane ‘Skeleton’ of Tumor and Lymphoid Cells: A Role in Cell Lysis?....Pages 387-400
p215 and p24: Two Membrane-Associated Proteins Expressed on Cloned Cytolytic T-Cells but not on Cloned Helper T-Cells....Pages 401-413
Mechanism of T-Dependent Cytotoxicity: Role of Papain-Sensitive Non Class I MHC Target Molecules and Expression of Target Antigen for Cytotoxicity....Pages 415-428
Cell-Cell Contact Proteins in Antigen-Specific and Antigen-Nonspecific Cellular Cytotoxicity....Pages 429-449
Front Matter....Pages 451-451
Evidence for the Molecular Dissociation of Binding and Post-Binding Functions in Cytotoxic T Lymphocytes....Pages 453-472
Immune Cytolysis Viewed as a Stimulatory Process of the Target....Pages 473-492
DNA Fragmentation in Targets of CTL: An Example of Programmed Cell Death in the Immune System....Pages 493-508
Mechanism of Rapid Tumor Lysis by Human ADCC: Mediation by Monoclonal Antibodies and Fragmentation of Target Cell DNA....Pages 509-525
Cell Surface Thiols, Methylation, and Complement-Like Components are Involved in the Early Events of CML Whereas Proteases Participate in the Later, Ca ++ -Dependent Events....Pages 527-534
Antigen/Mitogen Induced Cytolytic Activity and IL-2 Secretion in Memory-Like CTL-Hybridomas....Pages 535-550
Quantitative Models for the Kinetics of Cell-Mediated Cytotoxicity at the Single Cell Level....Pages 551-561
Back Matter....Pages 563-568