Mechanisms of B Cell Neoplasia 1998: Proceedings of the Workshop held at the Basel Institute for Immunology 4th–6th October 1998

Front Matter....Pages I-XXIX
Front Matter....Pages 1-1
The Formation and Selection of Cells Expressing PreB Cell Receptors and B Cell Receptors....Pages 3-10
Fetal Liver Organ Cultures as a Tool to Study Selection Processes During B Cell Development....Pages 11-19
Negative Selection of Self-reactive B Lymphocytes Involves Complement....Pages 21-29
Cross-talk Between CD44 and c-Met in B cells....Pages 31-38
The Transition from Immature to Mature B Cells....Pages 39-44
CD21 high IgM high Splenic B Cells Enriched in the Marginal Zone: Distinct Phenotypes and Functions....Pages 45-52
Do Germinal Centers Have a Role in the Generation of Lymphomas?....Pages 53-62
Role of Complement Receptors CD21/CD35 in B Lymphocyte Activation and Survival....Pages 63-69
Long-lived Plasma Cells Survive Independent of Antigen....Pages 71-75
Front Matter....Pages 77-77
Regulation of Expression of Chemokine Receptor BLR1/CXCR5 during B Cell Maturation....Pages 79-85
Chemokines and B-cell Homing to Follicles....Pages 87-93
A Novel CC Chemokine ABCD-1, Produced by Dendritic Cells and Activated B Cells, Exclusively Attracts Activated T Lymphocytes....Pages 95-101
Human Macrophage-Derived Chemokine (MDC) is Strongly Expressed Following Activation of both Normal and Malignant Precursor and Mature B Cells....Pages 103-110
Susceptibility Genes for AIDS and AIDS-Related Lymphoma....Pages 111-115
Molecular Mechanisms of T Helper Cell Differentiation and Tissue-specific Migration....Pages 117-122
The Role of Chemokine Receptors in Directing Traffic of Naive, Type 1 and Type 2 T Cells....Pages 123-129
A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids....Pages 131-137
Front Matter....Pages 139-139
Phenotypic and Molecular Characterization of Human Peripheral Blood B-cell Subsets with Special Reference to N-Region Addition and Jκ-Usage in VκJκ-Joints and κ/λ-Ratios ixn Naive Versus Memory B-cell Subsets to Identify Traces of Receptor Editing Processes....Pages 141-147
Tuning Somatic Hypermutation by Transcription....Pages 149-159
Immunoglobulin Gene Associated Chromosomal Translocations in B-Cell Derived Tumors....Pages 161-167
Front Matter....Pages 139-139
Analysis of B-cell Neoplasias by Spectral Karyotyping (SKY)....Pages 169-174
Recurrent Non-reciprocal Translocations of Chromosome 5 in Primary T(12;15)-positive BALB/c Plasmacytomas....Pages 175-181
MYC-Induced Cyclin D2 Genomic Instability in Murine B Cell Neoplasms....Pages 183-192
The Role of Somatic Hypermutation in the Generation of Deletions and Duplications in Human Ig V Region Genes and Chromosomal Translocations....Pages 193-198
Chromosome 13 Deletion in Myeloma....Pages 199-203
Unusual Immunoglobulin and T-cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemias....Pages 205-215
Analysis of Variable Heavy and Light Chain Genes in Follicular Lymphomas of Different Heavy Chain Isotype....Pages 217-224
Regulation of c-myc and Immunoglobulin κ Gene Transcription by Promoter-proximal Pausing of RNA Polymerase II....Pages 225-231
Front Matter....Pages 233-233
Epidemiology of B-Cell Lymphomas....Pages 235-240
Alternative Splicing of CD79a (Igα) and CD79b (Igß Transcripts in Human B-CLL Cells....Pages 241-248
Novel Aspects of Murine B Cell Lymphomas....Pages 249-255
Molecular Pathogenesis of B Cell Malignancy: the Role of BCL-6....Pages 257-265
ATM and Lymphoid Malignancies; Use of Oriented Peptide Libraries to Identify Novel Substrates of ATM Critical in Downstream Signaling Pathways....Pages 267-274
MHC-linked Control of Murine SLE....Pages 275-281
The Adaptor Protein SLP-65/BLNK Controls the Calcium Response in Activated B Cells....Pages 283-289
Involvement of the SHP-1 Tyrosine Phosphatase in Regulating B Lymphocyte Antigen Receptor Signaling, Proliferation and Transformation....Pages 291-298
Antigen Receptor Signaling Induces Differential Tyrosine Kinase Activation and Population Stability in B-Cell Lymphoma....Pages 299-305
Importance of CD44 Variant Isoforms in Mouse Models for Inflammatory Bowel Disease....Pages 307-313
EBNA2 and c-myc in B Cell Immortalization by Epstein-Barr Virus and in the Pathogenesis of Burkitt’s Lymphoma....Pages 315-321
Front Matter....Pages 323-323
The Control of Proliferation, Survival and Apoptosis in Human Multiple Myeloma Cells in vitro ....Pages 325-333
Front Matter....Pages 323-323
Activation Molecules on Human Myeloma Cells....Pages 335-341
Peritoneal B-1 Cells Switch in vivo to IgA and these IgA Antibodies can bind to Bacteria of the Normal Intestinal Microflora....Pages 343-350
Inhibition of Pristane-Induced Peritoneal Plasmacytoma Formation....Pages 351-362
The Role of p16 INK4a ( Cdkn2a ) in Mouse Plasma Cell Tumors....Pages 363-368
Transgenic Shuttle Vector Assays for Assessing Oxidative B-cell Mutagenesis in vivo ....Pages 369-377
Plasmacytoma Induction in Specific Pathogen-Free (SPF) bcl-2 Transgenic BALB/c Mice....Pages 379-385
Induction of B Cell Autoimmunity by Pristane....Pages 387-393
Cytokine Network Imbalances in Plasmacytoma-Regressor Mice....Pages 395-401
The Role of Human Herpesvirus-8, (HHV-8), in Multiple Myeloma Pathogenesis....Pages 403-409
Back Matter....Pages 411-418