Mechanisms in B-Cell Neoplasia 1990: Workshop at the National Cancer Institute National Institutes of Health Bethesda, MD, USA, March 28–30,1990

Front Matter....Pages I-XIX
Front Matter....Pages 1-1
IL-6 as a Growth Factor for Human Multiple Myeloma Cells - A Short Overview....Pages 3-12
Interleukin 6 (IL-6) and Its Receptor (IL-6R) in Myeloma/Plasmacytoma....Pages 13-22
Interleukin-6 is a Major Myeloma Cell Growth Factor In Vitro and In Vivo Especially in Patients with Terminal Disease....Pages 23-31
Macrophages as an Important Source of Paracrine IL6 in Myeloma Bone Marrow....Pages 33-36
Retroviral-Mediated Transfer of Interleukin-6 Into Hematopoietic Cells of Mice Results in a Syndrome Resembling Castleman’s Disease....Pages 37-41
A Monoclonal Antibody Specific for the Murine IL-6-Receptor Inhibits the Growth of a Mouse Plasmacytoma In Vivo....Pages 43-46
Production of IL-2 in CD25 Positive Malignant Lymphomas....Pages 47-49
IL-6 Induces Hybridoma Cell Growth Through a Novel Signalling Pathway....Pages 51-61
Selective Killing of IL6 Receptor Bearing Myeloma Cells Using Recombinant IL6-Pseudomonas Toxin....Pages 63-69
In Vitro Culture of a Primary Plasmacytoma that has Retained Its Dependence on Pristane Conditioned Microenvironment for Growth....Pages 71-74
Front Matter....Pages 75-75
Modulation of Growth and Differentiation of Murine Myeloma Cells by Immunoglobulin Binding Factors....Pages 77-85
A New Cell Adhesion Mechanism Involving Hyaluronate and CD44....Pages 87-90
The Activity of an ABL-MYC Retrovirus in Fibroblast Cell Lines and in Lymphocytes....Pages 91-96
Plasmacytoma Induction in BALB/c6;15 → DBA/2 Chimeras....Pages 97-105
Mouse Plasmacytoma Associated (MPC) T(15;16) Translocation Occurs Repeatedly in New MPC Induction System....Pages 107-119
A Retrovirus Expressing v- abl and c- myc Induces Plasmacytomas in 100% of Adult Pristane-Primed BALB/c Mice....Pages 121-127
Role of raf -1 Protein Kinase in IL-3 and GM-CSF-Mediated Signal Transduction....Pages 129-139
Identification of Consensus Genes Expressed in Plasmacytomas but Not B Lymphomas....Pages 141-147
Proliferation of B Cell Precursors in Bone Marrow of Pristane-Conditioned and Malaria-Infected Mice: Implications for B Cell Oncogenesis....Pages 149-157
The Human CBL Oncogene....Pages 159-164
Front Matter....Pages 75-75
Lymphoid Tumorigenesis by v- abl and BCR-v- abl in Transgenic Mice....Pages 165-173
Abnormalities of the Immune System Induced by Dysregulated bcl -2 Expression in Transgenic Mice....Pages 175-181
Front Matter....Pages 183-183
Immortalization of Primary Murine B Lymphocytes with Oncogene-Containing Retroviral Vectors....Pages 185-188
Functionality of Clonal Lymphoid Progenitor Cells Expressing the P210 BCR/ABL Oncogene....Pages 189-195
Constitutive and Cell Cycle Regulated Expression of c- myc mRNA is Related to the State of Differentiation in Murine B-Lymphoid Tumors....Pages 197-202
Bcl-2: B Cell Life, Death and Neoplasia....Pages 203-207
Front Matter....Pages 209-209
Binding of NF-KB-like Factors to Regulatory Sequences of the c- myc Gene....Pages 211-220
Tumorigenesis in Transgenic Mice Expressing the c- myc Oncogene with Various Lymphoid Enhancer Elements....Pages 221-231
Isolation of Normal and Tumor-Specific Pvt -1 cDNA Clones....Pages 233-241
Expression of c- myc and Pvt 1....Pages 243-249
Mutational Analysis of the Carboxy-Terminal Casein Kinase II Phosphorylation Site in Human c- myc ....Pages 251-258
The Transforming Activity of PP59C- MYC is Weaker Than That of v- myc ....Pages 259-265
Recombination of the c- myc Gene with IgH Enhancer-Sμ Sequences in a Murine Plasmacytoma (DCPC 21) Without Visible Chromosomal Translocations....Pages 267-278
Downstream Regulatory Elements in the c- myc Gene....Pages 279-284
DNA Repair in the c- myc Locus....Pages 285-291
Mechanism of Negative Feed-back Regulation of c- myc Gene Expression in B-Cells and its Inactivation in Tumor Cells....Pages 293-301
Moloney Murine Leukemia Virus Integration 1060 Base Pairs 5’ of c- myc Exon 1 in a Plasmacytoma Without a Chromosomal Translocation....Pages 303-306
Front Matter....Pages 307-307
Cell Phenotype Dependent Down-regulation of MHC Class I Antigens in Burkitt’s Lymphoma Cells....Pages 309-316
EBV-Associated B-Cell Lymphomas Following Transfer of Human Peripheral Blood Lymphocytes to Mice with Severe Combined Immune Deficiency....Pages 317-323
Analysis of Epstein-Barr Virus Gene Expression in Lymphomas Derived from Normal Human B Cells Grafted into SCID Mice....Pages 325-331
Front Matter....Pages 307-307
Deregulated c- myc Gene Expression and Persistence of EBV are Not Sufficient to Maintain the Malignant Phenotype in Burkitt’s Lymphoma x B-Lymphoblastoid Hybrid Cells....Pages 333-336
Epstein-Barr Virus Latency and Activation in Vivo....Pages 337-346
Relative Predispositional Effect of a PADPRP Marker Allele in B-Cell and Some Non B-Cell Malignancies....Pages 347-357
Epstein-Barr Virus Terminal Protein Gene Transcription is Dependent on EBNA2 Expression and Provides Evidence for Viral Integration into the Host Genome....Pages 359-366
Genomic Integration as a Novel Mechanism of EBV Persistence....Pages 367-374
Effect of TGF-beta on the Proliferation of B Cell Lines and on the Immortalisation of B Cells by EBV....Pages 375-380