Mechanisms in B-Cell Neoplasia 1988: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 23–25, 1988

Front Matter....Pages I-XIV
Front Matter....Pages 1-1
B Cell Precursors in Bone Marrow: In Vivo Proliferation, Localization, Stimulation by Activated Macrophages and Implications for Oncogenesis....Pages 2-10
Lymphoid-Restricted Stem Cells....Pages 11-15
Recombinant Interleukin-7 Supports the Growth of Normal B Lymphocyte Precursors....Pages 16-18
Mac-1 + Bone Marrow Cells Include Precursors of B Cells and T Cells....Pages 19-26
Molecular Characterization of a Transforming Retrovirus Involved in Pre-B Cell Lymphomas....Pages 27-30
In Vitro Transformation of Murine Bone Marrow Cells with a v- raf /v- myc Retrovirus Yields Clonally Related Mature B Cells and Macrophages....Pages 31-41
Closely Related BCR/ABL Oncogenes Are Associated with the Distinctive Clinical Biologies of Philadelphia Chromosome Positive Chronic Myelogenous and Acute Lymphocytic Leukemia....Pages 42-49
The Pathogenesis of Tumors Induced by Helper Virus-Free Abelson Murine Leukemia Virus....Pages 50-57
The Development of Three Distinct Avian B Cell Lymphomas....Pages 58-66
Bursal Stem Cells as Targets for myc -Induced Preneoplastic Proliferation and Maturation Arrest....Pages 67-74
Molecular Analysis of an AIDS-Associated Burkitt’s Lymphoma: Near-Identity with Endemic Cases....Pages 75-79
Transgenic Mouse Models for Hematopoietic Tumorigenesis....Pages 82-93
Genetic Studies on Eµ- myc Transgenic Mice....Pages 94-99
Differential Expression of myc -family Genes During Development: Normal and Deregulated N- myc Expression in Transgenic Mice....Pages 100-109
Plasmacytoma Induction by J Series of v- myc Recombinant Retroviruses: Evidence for the Requirement of Two ( raf and myc ) Oncogenes for Transformation....Pages 110-114
Synergy of an IgH Promoter-Enhancer-Driven c- myc /v-Ha- ras Retrovirus and Pristane in the Induction of Murine Plasmacytomas....Pages 115-124
The Genetics of Susceptibility to RIM-Induced Plasmacytomagenesis....Pages 125-127
Significance of Chromosome 8 Breakpoint Location in Burkitt’s Lymphoma: Correlation with Geographical Origin and Association with Epstein-Barr Virus....Pages 128-137
B Cell Proliferation in Follicles, Germinal Centre Formation and the Site of Neoplastic Transformation in Burkitt’s Lymphoma....Pages 138-148
Altered Growth Phenotype of a Burkitt’s Lymphoma Line Following the Introduction and Stable Expression of the EBNA 2A Gene....Pages 149-156
Front Matter....Pages 1-1
Soluble CD23/BLAST-2 (S-CD23/Blast-2) and Its Role in B Cell Proliferation....Pages 157-164
Burkitt’s Lymphoma Variant Translocations: Distribution of Chromosomal Breakpoints and Perturbated Regulation of a Mutated c- myc Gene....Pages 165-171
Differentiation Associated c- myc Expression in Phorbol Ester and Lymphokine Stimulated B-Type Chronic Lymphocytic Leukemia Cells....Pages 172-180
B and T Cell Responses Induced by Interleukin-6....Pages 181-184
Front Matter....Pages 185-185
Prediction of a Dimerization Surface Common to a New Class of Sequence-Specific DNA Binding Proteins....Pages 186-188
Immunological Probes in the Analysis of myc Protein Expression....Pages 189-201
The Replication Activity of SV40 DNA Correlates with the Level of c- myc Expression in Human Tumor Cell Lines....Pages 202-207
Elevated Levels of the c- myc Protein in Bloom’s Syndrome and Induction of c- myc by DNA Strand Breakage....Pages 208-215
Deregulation of the c- myc and N- myc Genes in Transformed Cells....Pages 216-222
Stimulation of the Antigen Receptor Complex Leads to Transcriptional Activation of the c- myc Gene in Normal Human T Cells....Pages 223-230
A Repressor of c- myc Transcription Is Found Specifically in Plasmacytomas....Pages 231-237
Regulation of c- myc Gene Transcription in B Lymphocytes: Mechanisms of Negative and Positive Control....Pages 238-246
Multifactorial Regulation of the Human c- myc Oncogene....Pages 247-252
Negative Control Elements Within and Near the Murine c- myc Gene....Pages 253-263
Disruption of the Putative c- myc Auto-Regulation Mechanism in a Human B Cell Line....Pages 264-268
Deregulated Expression of an Activated Allele of Human c- myc in Transfected Fibroblast Cultures....Pages 269-273
Comparison of c-, N-, and L- myc Transcriptional Regulation....Pages 274-281
Delivery of c- myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic Cells in Culture by Liposome Fusion: Specific Reduction in c- myc Protein Expression Correlates with Inhibition of Cell Growth and DNA Synthesis....Pages 282-289
Different Biological Effects of c- myc and H- ras Oncogene Expression in EBV-Infected Human Lymphoblasts....Pages 290-297
Abrogation of IL-3 Dependence of Myeloid FDC-P1 Cells by Tyrosine Kinase Oncogenes Is Associated with Induction of c- myc ....Pages 300-309
Front Matter....Pages 185-185
The Abelson Protein Is Required for Initiation and Maintenance for Transformation in Murine Pre-B Cells....Pages 310-315
Expression and Function of the c- myb Oncogene During Hematopoietic Differentiation....Pages 318-323
Sense and Anti-sense Transcription in the Murine c- myb Attenuator Region....Pages 324-329
Expression of the Murine Proto-Oncogene bcl -2 Is Stage Specific and Cell-Type Specific....Pages 332-336
Recent Progress on the Human bcl -2 Gene Involved in Follicular Lymphoma: Characterization of the Protein Products....Pages 337-340