Mechanisms and Models in Toxicology: Proceedings of the European Society of Toxicology Meeting Held in Harrogate, May 27–29, 1986

Front Matter....Pages I-VIII
Front Matter....Pages 1-1
Apoptosis: Cell Death Under Homeostatic Control....Pages 3-10
On The Role of Calcium in Chemical Toxicity....Pages 11-19
A Dynamic Liver Culture System: A Tool for Studying Chemical Biotransformation and Toxicity....Pages 20-33
Some Aspects of Cell Defense Mechanisms of Glutathione and Vitamin E During Cell Injury....Pages 34-38
Structure Activity Requirements for Induction of Peroxisomal Enzyme Activities in Primary Rat Hepatocyte Cultures....Pages 39-41
Oxidative and Reductive Biotransformation of Chloroform in Mouse Liver Microsomes....Pages 42-44
Effects of Subchronic Low-Protein Diet on Some Tissue Glutathione - Related Enzyme Activities in the Rat....Pages 45-49
Front Matter....Pages 51-51
Interorgan Shift of Nitrosamine Metabolism by Dietary Ethanol....Pages 53-65
Quantitative Evaluation of DNA-Binding Data In Vivo for Low-Dose Extrapolations....Pages 66-74
Persistent Organ Damage and Cancer Production in Rats and Mice....Pages 75-83
Sensitivity of DNA and Nucleotides to Oxidation by Permanganate and Hydrogen Peroxide....Pages 84-88
A Postlabelling Assay for N 7 -(2-Oxoethyl)Guanine, the Principal Vinyl Chloride-DNA Adduct....Pages 89-92
Comparison of Hydrocarbon – DNA Adducts Formed in Mouse and Human Skin Following Treatment with Benzo [A] Pyrene....Pages 93-98
Combined Radiolabelling Distribution and Covalent DNA-Binding Studies to Discriminate Between a Carcinogen/Noncarcinogen Pair of Monoazo Dyes Related to the Hepatocarcinogen Butter Yellow (DAB)....Pages 99-101
Front Matter....Pages 103-103
Teratogenicity Testing in Vitro: Status of Validation Studies....Pages 105-114
The Primate as a Model for Hazard Assessment of Teratogens in Humans....Pages 115-121
A Clinician’s View of Teratogenesis....Pages 122-127
Teratogenicity of Valproic Acid and Related Substances in the Mouse: Drug Accumulation and pH i in the Embryo During Organogenesis and Structure-Activity Considerations....Pages 128-139
Embryotoxic Action of β -Aminopropionitrile During Early Organogenesis in Rats....Pages 140-142
Valproic Acid Teratogenesis and Embryonic Lipid Metabolism....Pages 143-147
Front Matter....Pages 103-103
Prenatal Exposure to Methylazoxymethanol (MAM) Acetate: Effects on Ultrasonic Vocalization and Locomotor Activity in Rat Offspring....Pages 148-151
The Comparative Effects of Cytotoxic Agents on the Numbers of Oocytes in Mice....Pages 152-154
Development of a Method for Assessing the Acute Toxicity of Chemicals on Early Post-Implantation Embryos....Pages 155-158
The “Giant” Yolk Sac: A Model for Studying Transport Across Extra-Embryonic Membranes....Pages 159-162
The Effect of Ethanol on the Growth of Rat Embryos: The Role of Stage Dependency and Hyperosmolality....Pages 163-167
Modification of Teratogenic Action In Vitro Due to Reduced Culture Medium Serum Content....Pages 168-171
In Vitro Teratogenicity of Parbendazole....Pages 172-174
Front Matter....Pages 175-175
Predictive Tests for Occupational Allergies....Pages 177-181
Toxicological Evaluation of Biotechnology Products: A Regulatory Viewpoint....Pages 182-190
Myco-Protein: Safety Evaluation of a Novel Food....Pages 191-193
The Toxicology of the End Products From Biotechnology Processes....Pages 194-199
Comparison of Three Assays of Picogram Amounts of Residual Cellular DNA in Biological Products from Continuous Cell Lines....Pages 200-205
Front Matter....Pages 207-207
The Influence of Some Dithiocarbamates on Oxidative Drug Metabolism: Interaction with Cadmium....Pages 209-212
Mechanism of Damage to Liver Cells After Chronic Exposure to Low Doses of Cadmium Chloride....Pages 213-215
Sex-Related Interactions of Cadmium and Lead in Changing Cardiovascular Homeostasis and Tissue Metal Levels of Chronically Exposed Rats....Pages 216-219
Cytotoxic, Irritant and Fibrogenic Effects of Metal-Fume Particulate Materials Investigated by Intramuscular Injection in the Rat and Guinea Pig....Pages 220-222
Intrapulmonary Pretreatment by Metal-Fume Components Causing Inhibition of Delayed Hypersensitivity....Pages 223-226
The Effect of Lead and Aluminium on Rat Dihydropteridine Reductase....Pages 227-230
Intestinal Absorption of Aluminium in Rats: Effect of Sodium....Pages 231-235
Neurotoxicity of a Spent Phosphoric Acid Catalyst....Pages 236-239
Front Matter....Pages 207-207
The Effect of Solvents on the Toxicity of DDT to Fish Cells....Pages 240-242
The Effect of the Cholinergic Neurotoxin ECMA on Neural Function in Brain Reaggregate Cultures....Pages 243-246
Interactions of Thyroid Hormone and Tricyclic Antidepressants on Rat Brain β -Adrenoceptor Function....Pages 247-249
Thyroid Toxicity and Iodothyronine Deiodination....Pages 250-252
Increased Thyroxine Clearance in Rats Treated with High Doses of a Histamine H 2 -Antagonist, SKF 93479....Pages 253-256
Enzymic Deglycosylation of Ricin Lowers its Uptake by Rat Liver Non-Parenchymal Cells....Pages 257-260
Mutagen Activation by Hepatic Fractions from Conventional, Germfree and Monoassociated Rats....Pages 261-263
Effects of Metronidazole, Azanidazole, and Azathioprine on Cytochrome P 450 and Various Mono-Oxygenase Activities in Hepatic Microsomes from Control and Induced Mice....Pages 264-269
An Animal Model of Cisplatin-Induced Magnesium Deficiency....Pages 270-272
Quantitative Methods for Assessing the Effects of Some Anticancer Drugs on Mouse Spermatogenesis....Pages 273-276
Comparative Effects of Mitozolomide (M & B 39125, NSC 353451 and a Series of Standard Anticancer Drugs on Mouse Testis....Pages 277-280
1,3-Dinitrobenzene: Toxicity and Metabolism in Rat Testicular Cell Cultures....Pages 281-284
Collagen Synthesis in Rats with Silica-Induced Pulmonary Fibrosis....Pages 285-287
Pulmonary Toxicity of Naphthalene Derivatives in the Rat....Pages 288-291
Toxicology Information for the Canadian Workforce....Pages 292-294
Predicting the Safety of Medicines from Animal Toxicity Tests I. Rodents Alone....Pages 295-299
Predicting the Safety of Medicines from Animal Toxicity Tests II. Rodents and Non-Rodents....Pages 300-304
Comparative Activation of Paracetamol in the Rat, Mouse and Man....Pages 305-309
Nisoldipine, a New Calcium Antagonist, Elevates Plasma Levels of Digoxin....Pages 310-312
Influence of Inhibitors on the Thrombogenicity and Toxicity of Prothrombin Complex Concentrates....Pages 313-315
Front Matter....Pages 207-207
Lipid Parameters of a Non-Human Primate Following Administration of a High Fat Diet....Pages 316-318
Immunological Studies in Asthmatics Exposed to Allergens....Pages 319-320
The In Vitro Effects of Trichothecenes on the Immune System....Pages 321-324
Macrophage Migration Inhibition Test to Evaluate the Sensitizing Potential of Drugs in the Guinea Pig....Pages 325-328
An Evaluation of the Toxichromotest, a Bacterial Toxicity Bioassay, and an Assessment of its Potential Use in Human Poisoning....Pages 329-333
Cell Membrane Toxicity Detected with the Chromium-51 Release Test....Pages 334-337
An Inert Mixture for Solubilizing Lipophilic Drugs in Cell Culture Assays....Pages 338-343
Han/Wistar Rats Are Exceptionally Resistant to TCDD. II.....Pages 344-347
Back Matter....Pages 349-365