Mechanisms and Consequences of Proton Transport

Front Matter....Pages iii-xiii
The Gastric H,K-ATPase....Pages 1-17
Human Nongastric H,K-ATPase: Current View On Structure And Functional Properties....Pages 19-31
Functional Consequences of Subunit Interactions in Na,K- and H,K-ATPases....Pages 33-41
HKcαEncodes Ouabain-insensitive H,K-ATPase in Surface Cells of Rat Distal Colon....Pages 43-52
Molecular Diversity and Regulatory Heterogeneity of the H + ,K + -ATPases in Kidney....Pages 53-58
Mutational Analysis of Gastric Proton Pump, α- and β-Subunits....Pages 59-70
Structure-Activity Relationships of Na,K-ATPase and H,K-ATPase....Pages 71-82
The Effect of Mutations Within a Cluster of Homologous Amino Acids Present in the M5, M6 and M8 Transmembrane Regions of the H,K-ATPase....Pages 83-90
Host-Specific H. pylori Inhibition of H,K-ATPase α Subunit Gene Expression....Pages 91-99
H + K + -ATPase, the Dominant Gastric Autoantigen in Helicobacter pylori Infection....Pages 101-106
The Gastric H/K ATPase in the Pathogenesis of Autoimmune Gastritis....Pages 107-114
Duodenal Protection: Influence of Melatonin and other Intestinal Transmitters on Duodenal Bicarbonate Secretion and Enterocyte Signaling....Pages 115-122
Role of Cytokines in Helicobacter pylori -Induced Gastric Epithelial Cell Matrix Metalloproteinase Secretion and Activation....Pages 123-126
HCl Causes Less Intracellular Acidification In Surface Epithelial Cells Of Isolated Necturus Gastric Mucosa Than Other Inorganic Acids....Pages 127-130
Ethanol Increases Intracellular Free Calcium, Closes Gap Junctions and Decreases Cell Volume in Primary Cultured Rabbit Gastric Epithelial Cell Monolayers....Pages 131-134
Induction of Small Intestinal Damage by Inhibition of Both NO Synthase and COX-2....Pages 135-137
Role of Protein Kinases on Acid-Induced Duodenal Bicarbonate Secretion in Rats....Pages 139-142
Acid Induces Duodenal Epithelial Acidification and HC0 3 - Secretion via Activation of the Na + :HC0 3 - Cotransporter and CFTR in Mice....Pages 143-145
Insights Into the Cell Biology, Development and Pathology of the Gastric Mucosa Revealed in Gastric H/K ATPase and Gastrin-Deficient Mice....Pages 147-157
Genetically Engineered Animal Models: Physiological Studies with Gastrin in Transgenic Mice....Pages 159-167
Gastric Cytoprotection by Prostaglandin E2 — Relation to EP Receptor Subtypes —....Pages 169-180
Gastric Mucus Accumulation is Reduced in Helicobacter pylori Infected Transgenic Mice Expressing the Human α-1,3/4-Fucosyltransferase in Surface Epithelial Cells....Pages 181-183
New Insights Into Second Messenger Regulation Of Parietal Cell FunctionBy Novel Downstream Signaling Proteins....Pages 185-195
Functional Role of Protein KinaseB/Akt in Gastric Acid Secretion....Pages 197-207
Permeabilized Gastric Gland Models — A New Strategy for Analyzing Parietal Cell Signal Transduction....Pages 209-220
Parietal Cell Volume Regulation During Acid Secretion....Pages 221-232
Characterization, Regulation and Localization of the Gastric Cl - Channel Associated with Gastric Acid Secretion....Pages 233-245
Identification of Potassium Channels Associated With H + /K + -Atpase in the Parietal Cell....Pages 247-254
Kir2.1 K + Channels of the Gastric Parietal Cell....Pages 255-264
Kinetics of Activation of H + Secretion by Secretagogues in Relation to Changes in [Ca 2+ ] i in Isolated Gastric Glands....Pages 265-273
Measurement of Intracellular Calcium and Gastric Acid Secretion in Real Time Using Fluorescent Probes....Pages 275-278
Tissue and Cell Distribution of Parchorin, a Chloride Intracellular Channel-Related Protein....Pages 279-282
Scanning EM Studies of Gastric Oxyntic Cells with Special Reference to the Translocation of Tubulovesicular System towards the Intracellular Canaliculus....Pages 283-294
3-Dimensional Modeling of the Gastric Parietal Cell....Pages 295-304
Pharmacological Control of Gastric Acid Secretion via the Apical Membrane of Parietal Cells in Dogs....Pages 305-315
The Cytoskeleton As a Modulator of Gastric Secretion....Pages 317-326
Clathrin And Associated Proteins On Tubulovesicles And Apical Membranes Of Parietal Cells....Pages 327-334
Rab11 Interacting Proteins as Regulators of Parietal Cell Apical Recycling: Lessons from the Master....Pages 335-347
Regulation of Acid Secretion and Mucosal Permeability by F-actin in the Bullfrog Gastric Mucosa....Pages 349-360
Fluid Dynamics of the Excretory Flows of Zymogenic and Mucinous Contents in Rat Gastric Glands Processed by High Pressure Freezing/Freeze Substitution, with Special Reference to the Secretory Dynamics of Phospholipase A 2 and Phospholipase C γ 1....Pages 361-364
Back Matter....Pages 365-372