Mechanism of Toxic Action on Some Target Organs: Drugs and Other Substances Proceedings of the European Society of Toxicology Meeting held in Berlin (West), June 25—28, 1978

Front Matter....Pages I-X
Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity....Pages 1-8
Front Matter....Pages 9-9
Evaluation of Effects of Sexual Steroids on the Hypothalamic-Pituitary System of Animals and Man....Pages 11-39
Ultrastructure of Intermediate Lobe of the Pituitary and Melanocyte-Stimulating Hormone Secretion in Oestrogen-Induced Kidney Tumours in Male Hamsters....Pages 41-45
Role of Neuroendocrine System in Regulation of Mammary Tumors in Different Species....Pages 47-58
Evaluation of the Carcinogenic Effects of Estrogens, Progestins and Oral Contraceptives on Cervix, Uterus and Ovary of Animals and Man....Pages 59-84
Assessment of ACTH-Adrenal Activity After Treatment with a Glucocorticoid and an Antiandrogenic Steroid....Pages 85-92
Neuroendocrine Effects of Neuropsychotropic Drugs and Their Possible Influence on Toxic Reactions in Animals and Man — The Role of the Dopamine-Prolactin System....Pages 93-104
Motility and Stereotyped Behaviour Induced by Amphetamine and Apomorphine on Hypophysectomized and on Thyroidectomized Rats....Pages 105-109
Front Matter....Pages 111-111
Adaptive Liver Growth Induced by Xenobiotic Compounds: Its Nature and Mechanism....Pages 113-124
Growth Control in Regenerating Rat Liver....Pages 125-130
Control of Liver Growth by Growth Inhibitors (Chalones)....Pages 131-142
Nucleic Acid and Pyrimidine Nucleotide Metabolism During Liver Growth Induced by Xenobiotic Compounds....Pages 143-144
Early Biological Markers During Liver Carcinogenesis....Pages 145-155
Correlation of Liver Growth and Function During Liver Regeneration and Hepatocarcinogenesis....Pages 157-169
Liver Growth and Tumorigenesis in Rats....Pages 171-180
Liver Tumors and Steroid Hormones in Rats and Mice....Pages 181-195
The Effects of Dieldrin, Diet and Other Environmental Components on Enzyme Function and Tumour Incidence in Livers of CF-1 Mice....Pages 197-212
Front Matter....Pages 213-213
Enzymes as Regulators of Toxic Reactions by Electrophilic Metabolites....Pages 215-227
Pharmacokinetic Parameters Influencing Tissue Specificity in Chemical Carcinogenesis....Pages 229-238
Organ Specificity of Induction of Activating and Inactivating Enzymes by Cigarette Smoke and Cigarette Smoke Condensate....Pages 239-251
Front Matter....Pages 213-213
DNA Repair as Regulatory Factor in the Organotropy of Alkylating Carcinogens....Pages 253-261
Physiological Mechanisms of Diethylstilbestrol Organotropic Carcinogenesis....Pages 263-274
Diethylstilbestrol Metabolic Transformation in Relation to Organ Specific Tumor Manifestation....Pages 275-280
Organotropic Mutagenesis in Tissues of Chinese Hamsters Induced by Chemical Carcinogens....Pages 281-283
Modulation of the in vivo Covalent Binding of the Carcinogen Benzo(a)pyrene to Rat Liver DNA by Selective Induction of Microsomal and Nuclear Aryl Hydrocarbon Hydroxylase Activity....Pages 285-288
Front Matter....Pages 289-289
Estimation of the TCDD Toxic Potential in the Light of the Seveso Accident....Pages 291-302
Front Matter....Pages 303-303
Biological Threshold Limits for Benzene Based on Pharmacokinetics of Inhaled Benzene in Man....Pages 305-310
Short Term Effects of Clophen A 50 and of Dichlorobiphenyl in Rats....Pages 311-314
Toxic Effects of Di-n-octyltin Dichloride on the Thymus in Mice....Pages 315-320
2-Hydroxyoestradiol and (+)-Cyanidanol-3 Prevent Lipid Peroxidation of Isolated Rat Hepatocytes....Pages 321-326
Accentuation of White Phosphorus Induced Fatty Liver by Phenobarbitone in Male Rats Compared to Female Rats....Pages 327-331
Fatty Liver Induced by High Doses of Rifampicin in the Rat: Possible Relation with an Inhibition of RNA Polymerases in Eukariotic Cells....Pages 333-337
An Experimental Model for the Study of Hepatic Transport and Metabolism of Toxic Compounds....Pages 339-343
Effects of Subacute Toluene Inhalation on its Metabolism and Disposition in Rat....Pages 345-348
Drug-Nitrite Interactions: Species and Sex Differences in the Formation of Dimethylnitrosamine and its Effects on the Hepatic Enzyme Activities....Pages 349-354
Monoamine Oxidase Inhibiting and Toxic Effects of Acetyl-Phenylhydrazide on Rat Liver in Vivo....Pages 355-358
Side Effects of Colloidal Plasmasubstitutes on Hemostasis in Patients with Terminal Renal Failure....Pages 359-363
Accelerated Renal Elimination of Thallium in the Rat Due to Treatment with Furosemide or Potassium Ions....Pages 365-366
Entrance into Brain of Dextropropoxyphene and the Toxic Metabolite Norpropoxyphene....Pages 367-370
Comparison of the Acute Toxicity of Clioquinol, Histamine, and Chloroform in Different Strains of Mice....Pages 371-373
Front Matter....Pages 303-303
Prostaglandins in Rat Placenta Following Acute and Chronic Administration of Morphine....Pages 375-380
Effects of Two Structurally Different Antispermatogenic Compounds on the Synthesis of Steroids in Rat Testes....Pages 381-385
Ultrastructural Alterations Induced by Two Different Antispermatogenic Agents in the Seminiferous Epithelium of Rat Testes....Pages 387-392
Therapeutic Effects of the Bis-Pyridinium Salts HGG-12, HGG-42, and Atropine, Benactyzine in Organophosphate Poisoning of Dogs....Pages 393-396
Hormonal Control of Prothrombin Synthesis in Rat Liver Microsomes, with Special Reference to the Role of Estradiol, Testosterone and Prolactin....Pages 397-402
Lifespan Studies on Male and Female Mice and Rats Under SPF-Laboratory Conditions....Pages 403-407
The Loss of Creatine Phosphokinase (CK) from Intramuscular Injection Sites in Rabbits....Pages 409-409
In vivo Covalent Binding of Chemicals to DNA as a Short-Term Test for Carcinogenicity....Pages 411-415
A Dynamic System for Long-Term Toxicity Studies in Fish Under Laboratory Conditions....Pages 417-423
Effect of Intratracheal and Oral Application of Corticosteroids on the Adrenal Function Test in Beagle Dogs After ACTH-Stimulation....Pages 425-429
Drug Actions in Rats with Arteriosclerosis Induced by Toxic Doses of Vitamin D 2 ....Pages 431-435
Apparent Tropism of a Vasodilator, Mecinarone, for Melanin-Containing Tissues and Activation of Melanogenesis in the Beagle....Pages 437-437
Estrogenic Partial Effect of Norethisterone Enanthate in Relation to Tumor Induction in Rat Mammary Gland....Pages 439-443
The Special Suitability of Inbred Syrian Hamsters for Carcinogenesis Testing....Pages 445-450
Proliferation of Rat Liver Cells in Preneoplastic Nodules After Stimulation of Liver Growth by Xenobiotic Inducers....Pages 451-455
The Regulative Role of Food Consumption in the Induction of Rat Liver Cell Proliferation by Drugs and Environmental Pollutants....Pages 457-461
Induction of Pre-Malignant Hepatic Lesions: Comparative Effects of Vinyl Chloride and Trichloroethylene....Pages 463-463
Microsomal Vinyl Oxide Synthetase: Modification of its Kinetic Parameters by Chemical Carcinogens....Pages 465-469
Influence of Drugs on Activation and Inactivation of Hepatocarcinogenic Nitrosamines....Pages 471-477
Effect of DMN, Phenobarbital and Halothane on the Sedimentation Characteristics of Rat Liver DNA....Pages 479-482
Front Matter....Pages 303-303
Activities of Polycyclic Hydrocarbon Activating and Inactivating Enzymes in Human Lungs of Smokers, Non-Smokers, Lung-Cancer and Non-Cancer Patients....Pages 483-489
Demonstration of Drug-Ethanol Interactions by Changes in Activity of Hepatic Microsomal Oxidase/Oxygenase Cytochrome P-450 Function....Pages 491-496
Alcohol and Aldehyde Dehydrogenase on Chronic Ethanol Intoxication....Pages 497-497
Polycystic Changes in Rat Kidney Induced by Biphenyl Fed in Different Diets....Pages 499-502
Unscheduled DNA Synthesis in Male Rabbit Germ Cells Induced by Methylmethane Sulfonate, Cyclophosphamide and Adriamycin....Pages 503-507
Plasma Proteins — Animal Assays on Possible Cardiovascular Side-Effects....Pages 509-513
Exploitation of Toxicological Results and its Problems....Pages 515-515
Computer Analysis and Integration of Animal Pathology Data....Pages 517-520
Back Matter....Pages 521-534