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دسته بندی: قلب و عروق ویرایش: 2 نویسندگان: James K. Kirklin, Joseph G. Rogers سری: ISBN (شابک) : 9780323566995 ناشر: Elsevier سال نشر: 2019 تعداد صفحات: 293 زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 44 مگابایت
در صورت تبدیل فایل کتاب Mechanical Circulatory Support: A Companion to Braunwalds Heart Disease به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب پشتیبانی مکانیکی گردش خون: همراهی با بیماری قلبی براونوالد نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
نسخه گالینگور تمیز شده با صفحه بندی اصلاح شده، جهت گیری صفحه و نشانک ها.
Cleaned hardcover version with corrected pagination, page orientation and bookmarks.
Cover Inside Front cover MECHANICAL CIRCULATORY SUPPORT: A COMPANION TO BRAUNWALD’S HEART DISEASE Copyright Dedication Contributors Preface Braunwald’s Heart Disease Family of Books 1 Historical Aspects of Mechanical Circulatory Support Early mechanical circulatory support devices and technology development Establishing the Concept Clinical Application and Evolution of MCS Ongoing technology developments and devices Current state of mcs Disclosure Funding References 2 Advanced Heart Failure and Cardiogenic Shock Introduction Definition Etiology of cardiogenic shock Hemodynamic effects of cardiogenic shock Reduced Cardiac Output Hypotension Increased Filling Pressures Neurohormonal response to cardiogenic shock Lactic Acidosis Inflammatory pathways Nitric Oxide End organ injury Conclusion References 3 Risk Stratification in Advanced Heart Failure Introduction Acute versus chronic heart failure Hospitalization as a Prognostic Marker Heart failure with preserved ejection fraction Sudden cardiac death versus progressive heart failure Elderly versus transplant referral populations Renal dysfunction Biomarkers Natriuretic Peptides Metabolic and Inflammatory Markers Physical capacity and mortality risk in heart failure Six-Minute Walk Test Maximal Oxygen Uptake and Prognosis in Heart Failure Exercise hemodynamics Frailty Multivariable risk stratification in heart failure Models for Inpatients Models for Outpatients Conclusion References 4 Candidate Selection and Decision Making in Mechanical Circulatory Support Introduction Indications for mechanical circulatory support Bridge to Transplant Destination Therapy Non-MCS Alternatives Timing Objective Measures of Disease Severity Warranting MCS Heart Failure Risk Scores Contraindications to MCS—medical, cardiac Right Ventricular Dysfunction Ventricular Arrhythmia Cardiac Anatomy, Prior Surgery, and Valve Disease Contraindications to MCS—Medical, Noncardiac Hematologic, Gastrointestinal, and Anticoagulation Considerations Renal Dysfunction Pulmonary Disease Peripheral Vascular Disease Cancer Infection Diabetes Malnutrition and Obesity Neurologic Disease Frailty Contraindications to MCS—nonmedical Psychosocial Considerations Temporary support to assess candidacy Formal evaluation protocols Shared decision making Summary References 5 Acute Circulatory Support Introduction The spectrum of cardiogenic shock Short-term mechanical circulatory support devices Intraaortic Balloon Pump Support Percutaneous Ventricular Assist Devices: Left Ventricular Support The TandemHeart Left Ventricular Support System Impella Left Ventricular Support System Percutaneous Ventricular Assist Devices: Right Ventricular Support Impella RP Right Ventricular Support Device Protek Duo Right Ventricular Support Device Biventricular Support/Venoarterial Extracorporeal Membrane Oxygenation Venoarterial Extracorporeal Membrane Oxygenation Complication of temporary circulatory support Clinical outcomes in shock patients supported with short-term mechanical circulatory support Conclusions/summary Disclosures References 6 The Role of Extracorporeal Membrane Oxygenation in Cardiac Support Background Current ecmo technologies used in cardiac support Ecmo configurations and cannulation strategies for cardiac support Characteristics of ecmo vs other temporary mechanical circulatory support systems Indications for ecmo in patients with cardiac disease Heart Failure and Cardiogenic Shock Postcardiotomy Shock Septic Shock Extracorporeal CPR Bridge to Heart Transplantation or Durable LVAD Conclusion References 7 Understanding the Principles of Continuous-Flow Rotary Left Ventricular Assist Devices Introduction Historical perspective General pump design CF rotary pump design: axial versus centrifugal pumps Bearing design/impeller suspension Mechanical Bearing Noncontact Bearing Designs Hydrodynamic Bearing Magnet Bearing Hydrodynamic performance of CF pumps Interaction of the CF rotary pump and native heart Parallel and series circulation Flow estimation Limitations in flow control with cf rotary pumps Conclusion References 8 Hemocompatibility in Mechanical Circulatory Support Introduction Biological Factors Hemolysis Thrombosis High Shear Coagulation/Low Shear Hemocompatibility-Related Engineering Aspects Pump Configurations Pump Curves Surface Preparation/Roughness Flow Analysis (Device/Ventricle) Material Science Inflow/Outflow Cannula Shear Stress Speed Modulation Conclusions References 9 The Biological Response to Ventricular Unloading Introduction Cardiac hypertrophy-atrophy Contractile dysfunction, calcium handling, and cytoskeletal proteins Cardiac metabolism and bioenergetics Cell death and stress Natriuretic peptides and neurohormones Inflammatory markers Extracellular matrix and fibrosis Gene expression, rna, and proteomic profiling Endothelium and vasculature Studies on angiogenesis Future directions Summary References 10 Current Types of Devices for Durable Mechanical Circulatory Support Development of mechanical circulatory support systems Durable left ventricular assist devices HeartMate II LVAS HeartMate 3 LVAS HeartWare HVAD Jarvik 2000 Berlin Heart INCOR Berlin Heart EXCOR Pediatric Ventricular Assist Device Evaheart LVAS SynCardia Total Artificial Heart Future directions of mechanical circulatory support Summary References 11 Operative Techniques and Intraoperative Management Historical note Principles of device selection Preoperative assessment and preparation Implant operation Intraoperative considerations Valvular Incompetence and Repair Tricuspid Regurgitation Mitral Regurgitation Aortic Valve Patent Foramen Ovale Ventricular Arrhythmias Management of Weaning From Cardiopulmonary Bypass Management of the Right Ventricle Right Heart Failure Decisions About Right Ventricular Support Pump Selection for Right Heart Support Intraoperative Bleeding Sternal Reentry Postoperative care References 12 Postoperative VAD Management: Operating Room to Discharge and Beyond Surgical and Medical Considerations Perioperative management Considerations in the operating room relevant to subsequent ICU care Early postimplantation ICU care Early postimplantation medical management in the ICU Pharmacologic management in the ICU Preparing for home discharge Standard outpatient visit References 13 Adverse Events and Mitigation Strategies Introduction Definitions Time-related occurrence, contributing factors, and causation Risk Factors Adverse event burden and era effect Adverse events contributing to death Perioperative bleeding Surgical wound infections Pump-related infection Percutaneous Driveline Infection Pump Pocket Infections Infections of Blood Contacting Pump Components (Pump Endocarditis) Gastrointestinal bleeding Neurologic dysfunction Renal failure Device failure Pump thrombosis Other thromboembolic events Right Heart Failure Aortic Insufficiency Arrhythmias References 14 Right Heart Failure in Patients With Mechanical Circulatory Support Introduction Physiology and anatomy of the right ventricle Right ventricular failure in patients with chronic heart failure after lvad Definition of Right Ventricular Failure Pathophysiology of Right Ventricular Failure After LVAD Placement Right venticular afterload sensitivity and adaptation Preoperative evaluation and predictive risk scores Pulmonary artery pulsatility index Perioperative management of right ventricular function Mechanical circulatory support for right ventricular dysfunction Delayed right ventricular failure References 15 Clinical Trial Results in Mechanical Circulatory Support Disclosure Overview of Clinical Trials of Mechanical Circulatory Support Devices Pulsatile Flow HeartMate IP1000 HeartMate VE/XVE Novacor Continuous Flow—Axial HeartMate II Jarvik 2000 MicroMed DeBakey/HeartAssist 5 Continuous Flow—Centrifugal HVAD VentrAssist DuraHeart HeartMate 3 Quality of Life, Functional Status, and Adverse Events Elective LVAD Therapy Total Artificial Hearts Conclusion References 16 Psychosocial and Quality of Life Issues in Mechanical Circulatory Support Preimplantation considerations Disparities in Access to Mechanical Circulatory Support Informed Consent Decision-Making Capacity Informing Patients, Caregivers, and Families About Treatment Options Understanding of Treatment Options Agreement to Treatment Options Patient and Family Preferences and Decision-Making Psychosocial Evaluation for Mechanical Circulatory Support Psychosocial outcomes during mechanical circulatory support Patient Health-Related Quality of Life Physical Functional Health-Related Quality of Life Psychological Health-Related Quality of Life Social Health-Related Quality of Life Global Health-Related Quality of Life Patient Medical Adherence and Self-Care Family Caregiver Well-Being and Quality of Life Economic Burdens for the Patient and Family Psychosocial predictors of clinical outcomes during mechanical circulatory support Postimplantation and end-of-life considerations Postimplantation Outcomes Patient Health-Related Quality of Life After Heart Transplantation Patient Health-Related Quality of Life After Recovery From Mechanical Circulatory Support Palliative Care, Hospice, and End-of-Life Considerations Palliative Care and Hospice Consultation Discontinuation of Mechanical Circulatory Support Conclusions and future clinical and research directions References 17 Left Ventricular Assist Device in Special Population of Patients Case presentation Introduction Modification in surgical technique Left Ventricular Assist Device Pump Speed Management Potential patient population Summary References 18 Mechanical Circulatory Support in Pediatrics Introduction Heart failure in children Current devices for pediatric cardiac support Extracorporeal Membrane Oxygenation Left Ventricular Assist Devices Temporary Support Strategies Durable Strategies Continuous-flow devices Pulsatile devices Pediatric Device Initiatives Bridge-to-transplantation Management of pediatric patients receiving cardiac assist device therapy Indications for Mechanical Circulatory Support in Children Timing of Support and Device Selection Other topics in pediatric mechanical circulatory support Biventricular Assist Device Support Congenital Heart Disease Single-Ventricle Support Adult Congenital Heart Disease Adverse Events Anticoagulation Conclusion References 19 Facilitating Myocardial Recovery History of recovery and device explantation Possible explanations of the low rate of myocardial recovery Assessment of Myocardial Recovery Optimizing myocardial recovery Harefield protocol Harefield Protocol—Phase 1 Harefield Protocol—Phase 2 Harefield Protocol Prospective Trial—Pulsatile Pump Harefield Protocol Prospective Trial—Continuous-Flow Pump U.S. Harefield Recovery Protocol Study Remission From Stage D Heart Failure Study Surgery for myocardial recovery Insertion Explantation Quality of life after left ventricular assist device explantation Summary and next steps to enhance rate of recovery Using the Left Ventricular Assist Device as Myocardial Therapy Using the Left Ventricular Assist Device as a Platform for Adjuvant Therapy Left Ventricular Assist Devices in the Future References 20 The Critical Role of MCS Registries Origins of Intermacs/Pedimacs Intermacs Patient profiles Intermacs Profile definitions Relationship of Intermacs Profiles to Outcomes Evolving intent of durable mcs placement Overall outcomes Survival Quality of Life Adverse events Early Versus Late Adverse Events Freedom From Adverse Events and Patient Profile Registry comparison to alternative therapies Heart Transplant Investigational Device Therapy and Registry Data Contemporary Medical Therapy MedaMACS REVIVAL Impact of registry data on clinical use of vads Globalization of mcs registries References 21 Regulatory and Reimbursement Landscape for Mechanical Circulatory Support Introduction History of medical device regulations History of Reimbursement in the United States European Medical Device Regulations Medical Device Regulations in Rest of World Markets Global reimbursement Regulatory pathways for mechanical circulatory support devices Reimbursement pathways for mechanical circulatory support devices Where Will It Fit? Mechanical circulatory support device total product life cycle Design Preclinical Testing Clinical Testing Premarket Approval Creating reimbursement for left ventricular assist devices Pathways to Payment Cost-effectiveness Postmarket studies/surveillance Device tracking Mechanical circulatory support device registries Mechanical circulatory support device corrections and removals (recalls) Obsolescence Lessons learned Conclusions References 22 The Future of Mechanical Circulatory Support I. The trail blazed and the pathway ahead II. The future is leveraging the past Early Goals of Life, and then Life Outside the Hospital Exploring Long-Term Life with ‘Destination Therapy’ The Pathway to Improvement TECHNOLOGY Breakthroughs MANAGEMENT Improvements and Guidelines PATIENT Selection and Risk Mitigation The Era of Improving Survival III. The future is optimizing the present RECOGNIZING the OPPORTUNITIES MAPPING the Pathway to OPTIMIZATION OPTIMIZING TECHNOLOGY Improving HEMOCOMPATIBILITY The emerging science of hemocompatibility applied to device design Improving BIOCOMPATIBILITY Eliminating the need for ANTICOAGULATION Reducing INFECTION Extending Device DURABILITY Expanding FUNCTIONALITY Right Heart Support Bi-ventricular Support Smart Controllers Pulsatility Extending INDICATIONS Recovery Heart failure with preserved ejection fraction Enhancing QUALITY OF LIFE Facilitating IMPLANTATION Easing Device USE Remote Monitoring and Management Optimizing Management Optimizing SURGICAL Management Optimizing MEDICAL Management Optimizing LIFE-LONG Management OPTIMIZING PATIENTS Movement to EARLIER-STAGE PATIENTS Addressing PATIENT-SPECIFIC Characteristics IV. The future requires organization Heart Failure Networks Field-wide Collaboration V. The future is now References Index A B C D E F G H I J K L M N O P Q R S T U V W Inside Back Cover