Maturation Phenomenon in Cerebral Ischemia III: Defensive Mechanisms Versus Apoptosis Neuronal Recovery and Protection in Cerebral Infarction

Front Matter....Pages III-XVIII
Front Matter....Pages 1-1
Multiple Molecular Penumbras Associated with Focal Ischemia in Brain....Pages 3-14
Aspects of the Maturation Phenomenon Observed by the TUNEL Method....Pages 15-23
Delayed Gene Expression and Ischemic Brain Injury....Pages 25-31
The Role of Programmed Cell Death in Cerebral Ischemia....Pages 33-39
The Role of Caspase-3-like Protease in the Hippocampus After Transient Global lschemia....Pages 41-46
Alterations in Translation Initiation Following Global Brain Ischemia....Pages 47-52
Studies of Neuronal Necrosis and Apoptosis after Global Cerebral Ischemia in Superoxide Dismutase Transgenic and Knockout Mutants....Pages 53-63
Apoptosis-Related Genes Are Expressed in the Rat Model of Subarachnoid Hemorrhage....Pages 65-68
No Morphological Evidence of Apoptosis Following Mild to Severe Episodes of Four-Vessel-Occlusion Ischemia in Rats....Pages 69-74
Front Matter....Pages 75-75
Stimulation of β 2 -Adrenoceptors Induces Nerve Growth Factor and Inhibits Apoptosis in Rat Brain After Ischemia....Pages 77-86
Ischemia-Induced Dynamic Cellular Response in the Brain....Pages 87-93
Oxygen Free Radicals and Ischaemic Preconditioning in the Brain: Preliminary Data and a Hypothesis....Pages 95-103
Ischemic Tolerance in the Maturation of Disseminated Selective Neuronal Necrosis and Cerebral Infarction After Repetitive Ischemia....Pages 105-109
Upregulation of Vascular Endothelial Growth Factor Protein Levels in Global Ischemia Induced by Cardiac Arrest and Resuscitation in Rat Brain....Pages 111-116
Neuroprotective Effect of Hepatocyte Growth Factor....Pages 117-123
Front Matter....Pages 125-125
Tumor Necrosis Factor-α-Induced Ischemic Tolerance as Manifested by Microvascular and Endothelial Cell Responses....Pages 127-133
The Role of Glial and Inflammatory Reactions in Cerebral Ischemia....Pages 135-141
Effect of Endothelin A Receptor Antagonist on Neuronal Injury in Global and Focal Ischemia....Pages 143-150
Lowering of Ameboid Microglial Resistance to Hydrogen Peroxide by Propentofylline....Pages 151-157
Combination Therapy: A Promising Treatment Strategy for Cerebral Ischemia....Pages 159-167
Front Matter....Pages 125-125
Another Facet of Nitric Oxide: Reduction of Toxic Zinc Influx Through Voltage-Gated Channels....Pages 169-173
Slowly Progressive Neuronal Degeneration in Remote Areas After Focal Cerebral Ischemia....Pages 175-182
Metabolic Disturbances and Gene Responses Following Cortical Injury in Rats: Relationship to Spreading Depression....Pages 183-191
Protein Expression and Brain Plasticity After Transient Middle Cerebral Artery Occlusion in the Rat....Pages 193-202
Alteration of Cyclic Adenosine Monophosphate Binding in Ischemic Brain: Sensitive Metabolic Marker for Early Ischemic Tissue Damage....Pages 203-213
Front Matter....Pages 215-215
Role of Mitochondria in Immediate and Delayed Reperfusion Damage....Pages 217-225
Temporal Profile of Cortical Injury Following Ischemic Insult Just Below and at the Threshold Level for Induction of Infarction: Light and Electron Microscopic Study....Pages 227-235
Mitochondrial Dysfunction and Maturation Phenomenon in Ischemic Gerbil Cortex....Pages 237-241
Metabotropic Ca 2+ Signalling and Refilling of Ca 2+ Stores in Hippocampal Astrocytes Are Driven by Adenosine Triphosphate Supplied by Glycolysis....Pages 243-249
Brain-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor Treatment of Focal Cerebral Ischemia in Rat....Pages 251-260
Environmental Influence on Neurotrophic Gene Expression After Experimental Brain Infarction in the Rat....Pages 261-266
Delayed Neuronal Death in Experimental Ischemic Stroke....Pages 267-273
A Rat Model to Study Damage and Defense Mechanisms Under Penumbra Conditions....Pages 275-279
Instrumental Diagnosis and Treatment of Acute Ischemic Stroke: The Clinician’s Perspective....Pages 281-287
Front Matter....Pages 289-289
Mechanisms of Regulation of Cerebral Blood Flow....Pages 291-307
Front Matter....Pages 309-309
The Protective Effect of DY9760e, a Novel Calmodulin Antagonist, on Rat Permanent Middle Cerebral Artery Occlusion....Pages 311-311
Amelioration of Brain Damage Following Transient Focal Ischemia in Rats by ONO-2506: Relevance of Its Modulating Action on Astroglial Functions....Pages 313-314
The Effect of ONO-2506 on Permanent Focal Ischemia in Rats....Pages 315-315
Preconditioning with 5 Min Forebrain Ischemia Ameliorated Mortality and Brain Edema Caused by 15 Min Forebrain Ischemia in the Gerbil....Pages 317-318
Alteration of Control Mechanisms of Endoplasmic Reticulum Calcium Pools in Focal Cerebral Ischemia....Pages 319-320
Front Matter....Pages 309-309
Global Ischemia Induces Downregulation of GIuR2 mRNA and Increases AMPA Receptor-Mediated Ca 2+ Influx in Hippocampal CA1 Neurons....Pages 321-322
SPD 502 (NS 1209), a New Selective AMPA Antagonist, Reduces the Infarct Size in Rats Following Permanent Occlusion of the Middle Cerebral Artery....Pages 323-324
Neuroprotective Effects of Magnesium and Tirilazad in Rats Subjected to Transient Focal Cerebral lschemia....Pages 325-326
Do Natural Antioxidants Protect Neurons from Oxidative Stress Due to Their Anti-Radical Activity?....Pages 327-327
Carnosine Protects Neurons from Excitoxic Effects of NMDA and Kainate....Pages 329-329
Aspects of Tolerance and Apoptosis: Cell and Molecular Biological Studies....Pages 331-331
Front Matter....Pages 333-333
Round Table Summary....Pages 335-339
Back Matter....Pages 341-345