Mast Cells and Basophils: Development, Activation and Roles in Allergic Autoimmune Disease (Novartis Foundation Symposium 271)

MAST CELLS AND BASOPHILS: DEVELOPMENT, ACTIVATION AND ROLES IN ALLERGIC/AUTOIMMUNE DISEASE......Page 3
Contents......Page 9
Participants......Page 13
Chair’s introduction......Page 17
MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells......Page 20
Discussion......Page 27
Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells......Page 31
Discussion......Page 40
The role of Src family kinases in mast cell effector function......Page 55
Discussion......Page 63
RasGRP4 in mast-cell signalling and disease susceptibility......Page 70
Discussion......Page 84
Regulation of mast cell secretory response to the type I Fce receptor: inhibitory elements and desensitisation......Page 94
Discussion......Page 105
General discussion I......Page 111
IgE regulation of mast cell survival and function......Page 116
Discussion......Page 124
RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation......Page 131
Discussion......Page 140
Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FceRI- and/or CCR1-engaged mast cells using protein chip technology......Page 147
Discussion......Page 156
General discussion III......Page 214
The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract......Page 168
Discussion......Page 177
The mast cell and the cysteinyl leukotrienes......Page 182
Discussion......Page 192
Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes......Page 195
Discussion......Page 203
The involvement of Bcl-2 in mast cell apoptosis......Page 207
Discussion......Page 211
Mast cells in autoantibody responses and arthritis......Page 216
Discussion......Page 226
MASTering the immune response: mast cells in autoimmunity......Page 231
Discussion......Page 241
Mastocytosis......Page 248
Discussion......Page 258
Index of contributors......Page 266
Subject index......Page 268