MAO — The Mother of all Amine Oxidases

Front Matter....Pages I-XIX
Determination of regions important for Monoamine Oxidase (MAO) A and B substrate and inhibitor selectivities....Pages 1-8
Monoamine oxidase A deficiency: Biogenic amine metabolites in random urine samples....Pages 9-15
Relationship between monoamine oxidase (MAO) A specific activity and proportion of human skin fibroblasts which express the enzyme in culture....Pages 17-27
Are MAO-A deficiency states in the general population and in putative high-risk populations highly uncommon?....Pages 29-38
Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)....Pages 39-48
Experience with tranylcypromine in early Parkinson’s disease....Pages 49-61
Deprenyl monotherapy improves visuo-motor control in early parkinsonism....Pages 63-69
Endogenous monoamine oxidase A inhibitory activity (tribulin), measured in saliva, is related to cardiovascular reactivity in normal individuals....Pages 71-77
MAO inhibitory side effects of neuroleptics and platelet serotonin content in schizophrenic patients....Pages 79-85
Modulation of glutamate neurotoxicity in the transformed cell culture by monoamine oxidase inhibitors, clorgyline and deprenyl....Pages 87-91
A cell culture model of cerebral ischemia as a convenient system to screen for neuroprotective drugs....Pages 93-98
Neuroprotection by selegiline and other MAO inhibitors....Pages 99-107
The neuroprotective and neuronal rescue effects of (—)-deprenyl....Pages 109-123
Oxidation of N-methyl(R)salsolinol: involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines....Pages 125-138
Substrate regulation of monoamine oxidases....Pages 139-147
Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics....Pages 149-171
Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology....Pages 173-187
Structure-function relationships of mitochondrial monoamine oxidase A and B: chimaeric enzymes and site-directed mutagenesis studies....Pages 189-200
Deamination of methylamine and angiopathy; toxicity of formaldehyde, oxidative stress and relevance to protein glycoxidation in diabetes....Pages 201-216
Monoamine oxidase activities in human cystic and colonic arteries — influence of age....Pages 217-223
Influence of maturation and ageing on the biotransformation of noradrenaline in the rat....Pages 225-232
The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver....Pages 233-238
Properties and functions of tissue-bound semicarbazide-sensitive amine oxidases in isolated cell preparations and cell cultures....Pages 239-250
Studies on the time-dependent activation of microsomal semicarbazide-sensitive amine oxidase....Pages 251-257
Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine....Pages 259-264
Semicarbazide-sensitive amine oxidase in pig heart....Pages 265-270
Chronic TVP-1012 (rasagiline) dose — activity response of monoamine oxidases A and B in the brain of the common marmoset....Pages 271-278
Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey....Pages 279-285
Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders....Pages 287-300
(R)(+)-N-Propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B....Pages 301-305
Function of endogenous monoamine oxidase inhibitors (tribulin)....Pages 307-313
Long term administration of (—)-deprenyl increases mortality in male Wistar rats....Pages 315-320
Selegiline as immunostimulant — a novel mechanism of action?....Pages 321-328
Clorgyline effect on pineal melatonin biosynthesis in rats with lesioned suprachiasmatic nuclei....Pages 329-332
The effect of MAO-A inhibition and cold-immobilization stress on N-acetylserotonin and melatonin in SHR and WKY rats....Pages 333-336
The influence of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase A and GABA A receptor binding....Pages 337-342
“In vitro” effect of some 5-hydroxy-indolalkylamine derivatives on monoamine uptake system....Pages 343-349
N-Alkyloxycarbonyl derivatives of ethylene diamine as monoamine oxidase inhibitors....Pages 351-355
Back Matter....Pages 357-363