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دانلود کتاب Macropinocytosis: Functions and Mechanisms (Subcellular Biochemistry, 98)
دانلود کتاب ماکروپینوسیتوز: عملکردها و مکانیسم ها (بیوشیمی زیر سلولی، 98)
مشخصات کتاب
Macropinocytosis: Functions and Mechanisms (Subcellular Biochemistry, 98)
ویرایش: [1st ed. 2022]
نویسندگان: Cosimo Commisso (editor)
سری:
ISBN (شابک) : 3030940039, 9783030940034
ناشر: Springer
سال نشر: 2022
تعداد صفحات: 235
[227]
زبان: English
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود)
حجم فایل: 6 Mb
قیمت کتاب (تومان) : 50,000
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توجه داشته باشید کتاب ماکروپینوسیتوز: عملکردها و مکانیسم ها (بیوشیمی زیر سلولی، 98) نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب ماکروپینوسیتوز: عملکردها و مکانیسم ها (بیوشیمی زیر سلولی، 98)
توضیحاتی درمورد کتاب به خارجی
This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process.
Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.
فهرست مطالب
Preface Macropinocytosis: Functions and Mechanisms Macropinocytosis: A Diverse Landscape of Functionality Regulation of Macropinocytosis by Signaling Molecules Contents About the Editor Part I: Functions of Macropinocytosis Chapter 1: Functional Diversity of Macropinocytosis Introduction Nutrient Transporters: A Specialized Protein Pumps to Intake Small Molecules ``Endocytosis´´: Intake of Macromolecules Phagocytosis Pinocytosis Clathrin-Mediated Endocytosis Caveolae-Mediated Endocytosis Macropinocytosis Functions of Macropinocytosis in Different Cell Types Role in Immune Surveillance Role in Fueling Cancer Cells Role in Inducing Methuosis Conclusions References Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways Introduction Nutrient Deprivation as a Driver of Macropinocytosis Amino Acid Scarcity and Macropinocytosis Macropinocytosis in the Setting of Glucose Deprivation Macropinocytosis and Oxidative Stress Macropinocytosis and Hypoxia Signaling Pathways That Regulate Macropinocytosis in the Context of Tumor Stress Growth Factors and Cytokines Ras, Rac, and PI3K mTOR PTEN and AMPK Concluding Remarks References Chapter 3: The Amoebal Model for Macropinocytosis Introduction The Dictyostelium Model for Macropinocytosis PIP3 Domains and Macropinocytosis How Macropinosomes Form Genetics of Macropinocytosis Cytoskeletal Proteins and the Structure of Macropinocytic Cups Signalling Proteins and the PIP3 Domain Shaping Macropinocytic Cups: PIP3 Domains and SCAR/WAVE Rings Conclusions and Future Perspectives References Chapter 4: Extracellular ATP and Macropinocytosis: Their Interactive and Mutually Supportive Roles in Cell Growth, Drug Resist... Introduction Intratumoral Extracellular ATP Macropinocytosis Scientific and Technological Challenges in ATP Research Instability of ATP ATP Release from Macropinosomes Multi-locational and Multi-functional Extracellular ATP in Cancer ATP as an Energy Provider for Biochemical Reactions ATP as a Phosphate Donor for Protein Phosphorylation and Signal Transduction Beyond Drug Resistance: eATP Induces EMT ATP and TGF-β Macropinocytosis as a Self-Propelled Process in Cancer Cells Targeting Macropinocytosis and eATP in Cancer Therapy Targeting Macropinocytosis Targeting Extracellular ATP Conclusions and Future Research Perspectives References Chapter 5: Macropinocytosis and Cell Migration: Don´t Drink and Drive Macropinocytosis Versus Cell Migration: Two Antagonistic Processes Antagonism Between Macropinocytosis and Cell Migration: Molecular Mechanisms The Role of Small GTPases The Role of Phosphoinositides Compartmentalization of the Actomyosin Cytoskeleton Physiological Impact of the Antagonism Between Macropinocytosis and Cell Migration Environment Exploration Cell Guidance by Extracellular Cues Conclusion References Chapter 6: Macropinocytosis in Phagocyte Function and Immunity Introduction Constitutive Macropinocytosis: Turning Ruffles in Vesicles Constitutive Macropinocytosis in Pathogen and Damage Sensing Constitutive Macropinocytosis and Antigen Presentation Emerging Roles for Macropinocytosis in Phagocyte Function Conclusion References Part II: Signaling Mechanisms Driving Macropinocytosis Chapter 7: Roles for 3´ Phosphoinositides in Macropinocytosis Introduction Phosphoinositides and the Enzymes that Affect their Abundance Enzymes that Synthesize or Degrade 3´PIs How Phosphoinositides Organize Cytoplasm Localization and Mapping of 3´PIs and Associated Chemistries The Cellular Activities Essential for Macropinocytosis 3´PI-Dependent Activities of Macropinocytosis Class I PI3K Is Necessary for Some But not all Ruffling Class I PI3K and Macropinosome Closure PtdIns3P Facilitates Macropinosome Formation and Macropinosome Maturation Synthesis of PtdIns(3,5)P2 by PIKfyve Mediates Macropinosome Shrinkage Roles for PI3K in Macropinocytosis by Dictyostelium discoideum Feedback Regulation of Macropinocytosis by 3´PIs Remaining Questions References Chapter 8: Signaling Pathways that Regulate Macropinocytosis in Mammalian Cells Introduction Cell-Intrinsic Signaling Events that Regulate Macropinosome Formation The Process of Macropinocytosis Ras and PI3-Kinase: The Central Regulators of Macropinocytosis Downstream Effectors of Ras and PI3-Kinase Intracellular Fate of Macropinosomes Regulation of Macropinocytosis by Growth Factor Signaling Cell-Extrinsic Regulation of Macropinocytosis by Growth Factors Transduction of Growth Factor Signals by Receptor Tyrosine Kinases Receptor Tyrosine Kinase Signaling Through the Ras and PI3-Kinase Pathways Metabolic Regulation of Macropinocytosis Coordination of Cellular Functions with Metabolic Environment Through Nutrient Sensors Regulation of Macropinocytosis by AMPK Regulation of Macropinocytic Cargo Degradation by mTORC1 Regulation of mTORC1 by Macropinocytosis Similarities and Differences between Macropinocytosis and Autophagy Induction of Macropinocytosis by Signaling Pathways that Regulate Development and Tissue Homeostasis Transcriptional Macropinocytosis Regulation by Hippo Signaling Transcriptional and Acute Macropinocytosis Regulation by Canonical Wnt Signaling Regulation of Macropinocytosis by Oncogenic Signaling Concluding Remarks References Chapter 9: Wnt, GSK3, and Macropinocytosis Introduction Endosomal Sequestration of GSK3 during Wnt Signaling Macropinocytosis RTK Growth Factor Signaling and Macropinocytosis Canonical Wnt and Macropinocytosis Macropinocytosis is Induced by Loss-of-Function of APC and Axin1 Rapid Macropinocytosis Induction by Wnt in the Absence of New Protein Synthesis GSK3 Represses Macropinocytosis Endocytosis and Canonical Wnt Signaling Wnt-induced Macropinocytosis Increases Lysosomal Acidification and Activity Conclusions References Chapter 10: KRAS Addiction Promotes Cancer Cell Adaptation in Harsh Microenvironment Through Macropinocytosis KRAS Addiction in Cancer KRAS, a Multifaceted Protein KRAS-driven Cancer Heterogeneity, a Hint to Understand KRAS Addiction KRAS Localization, a Critical Aspect of KRAS Addiction Tumor Microenvironment, a Clandestine Modulator of KRAS Addiction Macropinocytosis and Cancer Cell Adaptation Macropinocytosis, an Advantage for KRAS-Addicted Cell Promoting Survival Integrin, a Key Mediator of KRAS-Driven Macropinocytosis Integrin Trafficking, a Modulator of Cell Metabolism References Chapter 11: KRASG12R-Independent Macropinocytosis in Pancreatic Cancer Introduction KRAS-Dependent Constitutive Macropinocytosis in Pancreatic Cancer The Atypical KRASG12R Mutant Has Disrupted Regulator Interactions KRASG12R Cannot Bind to p110α and Fails to Promote Macropinocytosis The (Non)redundant Role of PI3K Isoforms in KRASG12R Macropinocytosis Tying it all Together References Index
