Macrophages and Natural Killer Cells: Regulation and Function

Front Matter....Pages i-xxviii
Front Matter....Pages 1-1
The Impact of Immunology on Medicine....Pages 3-17
Front Matter....Pages 19-19
Membrane Receptors and the Regulation of Mononuclear Phagocyte Effector Functions....Pages 21-31
Regulation of Macrophage Production....Pages 33-48
Symbiotic Relationships between Macrophages and Lymphocytes....Pages 49-63
Macrophages and Cancer Metastasis....Pages 65-75
Immunological Surveillance Versus Immunological Stimulation of Oncogenesis- a Formal Proof of the Stimulation Hypothesis....Pages 77-85
Front Matter....Pages 87-87
Physical and Chemical Determinants of Leucocyte Locomotion....Pages 89-99
Functionally Distinct Subpopulations of Human Monocytes: Receptors for F-Met-Leu-Phe are Expressed only on the Chemotactically Responsive Cells....Pages 101-106
Modulation of Granulocyte Response to the Chemoattractant F-Met-Leu-Phe....Pages 107-112
Cytoskeleton-Membrane Interaction and the Remodeling of the Cell Surface During Phagocytosis and Chemotaxis....Pages 113-131
Enhancement of Phagocytosis by Neurotensin, a Newly Found Biological Activity of the Neuropeptide....Pages 133-141
A Membrane Lectin on Macrophages: Localization and Demonstration of Receptor Recycling....Pages 143-149
Cationic Polyelectrolytes and Leukocyte Factors Function as Opsonins, Triggers of Chemiluminescence and Activators of Autolytic Enzymes in Bacteria: Modulation by Anionic Polyelectrolytes in Relation to Inflammation....Pages 151-160
Phagocytic Enhancement of Granulocytes and Monocytes by Cationic Proteins from Human Polymorphonuclear Leukocytes....Pages 161-164
Inhibition of Complement Dependent Phagocytosis by Normal Human Monocytes Following Preincubation with Immune Complexes....Pages 165-171
Front Matter....Pages 173-173
Comparison of the In Vivo and In Vitro Proliferation of Monoblasts, Promonocytes, and the Macrophage Cell Line J774....Pages 175-187
Properties of the Factor Increasing Monocytopoiesis (FIM) in Rabbit Peripheral Blood....Pages 189-193
Monocyte Production and Kinetics in Response to Listeriosis in Resistant and Susceptible Murine Hosts....Pages 195-200
MG-1, Identification of an Early Differentiation Marker for Bone Marrow Cells in a Monocytic/Granulocytic Lineage....Pages 201-207
Isolation and Characterization of Human Monocyte Subsets....Pages 209-219
Front Matter....Pages 173-173
Separation and Characterization of Guinea Pig Monocyte Subsets using Counter-Flow Centrifugation Elutriation (CCE)....Pages 221-225
Changes in Surface Markers of Human Monocytes Following Their In Vitro Maturation to Macrophages....Pages 227-232
Correlation between Two New Methods for the Isolation of Human Monocytes: Specific Reversible Agglutination with a Carbohydrate from Pokeweed and by use of the Lectin PA-4....Pages 233-239
Characteristics of Human Monocyte Subpopulations with the use of Flow Cytometer....Pages 241-245
Front Matter....Pages 247-247
Growth Regulation by Macrophages....Pages 249-260
Regulation of Bone-Marrow Macrophage Proliferation....Pages 261-266
Use of Glucan to Enhance Hemopoietic Recovery after Exposure to Cobalt-60 Irradiation....Pages 267-272
The Role of Helper Monocytes in Mitogenic Activation of Human T-Lymphocyte Subpopulations....Pages 273-280
Selection of an Immunogenic 3LL Tumor Subline Following Serial Growth In Vivo in the Local Presence of Peritoneal Macrophages....Pages 281-288
Mononuclear Phagocytes in the Control of Primary and Secondary Tumor Growth....Pages 289-302
Front Matter....Pages 303-303
Synthesis and Release of Lytic Enzymes by Macrophages in Chronic Inflammation....Pages 305-312
Weak-Base Induced Lysosomal Secretion by Macrophages: An Alternative Trigger Mechanism that is Independent of Complement Activation....Pages 313-323
Inflammatory Response of LPS-Hyporesponsive and LPS-Responsive Mice to Challenge with Gram-Negative Bacteria Salmonella Typhimurium and Klebsiella Pneumoniae ....Pages 325-334
Characterization of the Leucocytic Infiltrate of Rheumatoid Synovium from Tissue Sections and Synovial Eluates....Pages 335-341
Inhibitors of Monocyte Responses to Chemotaxins are Associated with Human Neoplasms....Pages 343-352
Depression of Monocyte Inflammatory Response with Pregnancy, Cancer, Regeneration and Surgical Wound Repair....Pages 353-359
Pulmonary Alveolar Macrophage Chemotaxis in Malignant Tumors of the Lung....Pages 361-367
Serum Blocking Factors in Tumor Bearing Hosts: The Value of Extended Plasma Exchange on In Vitro Immune Parameters of Patients with Advanced Cancer....Pages 369-378
The Role of the Inflammatory Response During Tumor Growth....Pages 379-387
Front Matter....Pages 389-389
Differentiation Antigens and Macrophage Heterogeneity....Pages 391-400
Front Matter....Pages 389-389
Surface Properties of Activated Macrophages: Sensitized Lymphocytes, Specific Antigen and Lymphokines Reduce Expression of Antigen F4/80 and FC and Mannose/Fucosyl Receptors, but Induce Ia....Pages 401-407
Antigenic Markers on Human Monocytes and Macrophages....Pages 409-421
Human Mononuclear Phagocytes Differentiation Antigens....Pages 423-427
A Cell Surface Marker Expressed on Cytotoxic Peritoneal Macrophages and Normal Lung Macrophages....Pages 429-434
Macrophage Functional Heterogeneity....Pages 435-443
Macrophage Hybridomas: An Approach to the Analysis of the Functional Heterogeneity of Macrophages....Pages 445-451
Distinction of Macrophage Subpopulations: Measurement of Functional Cell Parameters by Flow Cytometry....Pages 453-459
Flow Cytometric Characterization of Macrophages: Fluorescent Substrates as Markers of Activation and Differentiation....Pages 461-468
Front Matter....Pages 469-469
Extrinsic Regulation of Macrophage Function by Lymphokines — Effect of Lymphokines on the Stimulated Oxidative Metabolism of Macrophages....Pages 471-485
Activation of Tumoricidal and/or Suppressor Macrophages: Different Stimulatory Signals Trigger Either Function both in Vivo and In Vitro ....Pages 487-492
Production of Macrophage Activating Factor by Cytolytic and Noncytolytic T Lymphocyte Clones....Pages 493-498
Identification of a T Cell Hybridoma which Produces Extraordinary Quantities of Macrophage Activating Factor....Pages 499-506
Autoregulation of Mononuclear Phagocyte Function....Pages 507-517
Regulation of Macrophage Functions by Interferon....Pages 519-524
Influence of Macrophage Activation on the Synthesis of Complement Components C2, C3, C4....Pages 525-529
Peritoneal Macrophages Release Prostaglandin E and Thromboxane B 2 in Response to C3b....Pages 531-534
Prostaglandin E 2 is a Feed-Back Regulator of Macrophage Activation....Pages 535-540
Front Matter....Pages 541-541
Mechanisms Controlling Differentiation and Function of Antigen-Presenting Macrophages....Pages 543-548
Characteristics of an IA + Antigen-Presenting Tumor Cell Line....Pages 549-556
Antigen Presentation In Vitro by a Murine Macrophage Cell Line....Pages 557-561
Front Matter....Pages 541-541
 Ir Gene Regulation of T Cell Proliferation: Requirement for Ia and Antigen Expression on the Same Accessory Cell....Pages 563-568
Biochemical Evidence for Multiple Ia Molecules....Pages 569-577
Ia Determinants on Macrophages: Significance and Role in the Immune Response....Pages 579-590
Regulation of Macrophage Ia Expression In Vivo and In Vitro ....Pages 591-599
Ia and Macrophages in Alloproliferation and Allocytotoxicity....Pages 601-609
Front Matter....Pages 611-611
Fibronectin: A Mediator of Phagocytosis and Its Potential in Treating Septic Shock....Pages 613-621
Fibronectin Binds to Charge-Modified Proteins....Pages 623-628
RES-Saturation with Accumulation of Hemoglobin-Haptoglobin Complexes in Plasma. A Method for Simultaneous Quantitation of Free Haptoglobin and Hemoglobin-Haptoglobin Complexes....Pages 629-634
α 2 M-Proteinase Complexes are Taken up by Macrophages During Joint Inflammation....Pages 635-639
Splenic Function in Primary Glomerulonephritis....Pages 641-648
Immunopathology of Pulmonary Granulomas....Pages 649-657
An Investigation about Cell Proliferation in Lymph Node Granulomas Obtained from Sarcoidosis Patients....Pages 659-665
Functional Assessment of Alveolar Macrophages in Allergic Asthmatic Patients....Pages 667-671
Front Matter....Pages 673-673
Macrophage Activation and Effector Mechanisms against Microbes....Pages 675-686
Release of Superoxide and Hydrogen Peroxide from Guinea-Pig Alveolar Macrophages during Phagocytosis of Mycobacterium Bovis BCG....Pages 687-693
Stimulation by Various Lectins of Intracellular Killing of Micro-Organisms by Phagocytic Cells....Pages 695-700
Glucan Immunomodulation in Experimental E. Coli Sepsis....Pages 701-706
Activation of Murine Mononuclear Phagocytes for Destroying Tumor Cells: Analysis of Effector Mechanisms and Development....Pages 707-720
Human Monocyte Killing of Tumor Cells: Contribution of an Extracellular Cytotoxin....Pages 721-729
The Effect of C. Parvum Therapy on Intratumoral Macrophage Subpopulations....Pages 731-736
Front Matter....Pages 673-673
Tumoricidal and Immunoregulatory Activity of Macrophages from Human Ovarian Carcinomas....Pages 737-744
Front Matter....Pages 745-746
Natural Resistance Mechanisms: Introduction....Pages 747-748
Naturally Occurring Cytotoxic Cells....Pages 749-759
Regulation of Natural Cytotoxic Activity....Pages 761-771
The Role of NK Cells in Resistance of In Vivo Tumors....Pages 773-784
Role of Natural Killer Cells and of Interferon in Natural Resistance against Virus Infections....Pages 785-797
Overview and Perspectives: Natural Resistance Mechanisms....Pages 799-808
Front Matter....Pages 809-809
A Pessimist at the Congress....Pages 811-811
The Macrophage and Cancer Pas de Deux....Pages 813-815
Back Matter....Pages 817-847