Lung Biology in Health & Disease Volume 177 Therapeutic Targets in Airway Inflammation

INTRODUCTION......Page 13
PREFACE......Page 15
CONTRIBUTORS......Page 17
CONTENTS......Page 25
Pathophysiology of Airway Inflammation in Asthma......Page 41
Primary Human Lung Cells in the Evaluation of Airway Inflammation......Page 95
Airway pH Homeostasis in Asthma and Other Inflammatory Lung Diseases......Page 103
Monitoring of Exhaled Breath to Assess Airway Inflammation in Asthma......Page 121
The Modulatory Effects of Carbon Monoxide on the Inflammatory Response......Page 133
Reactive Nitrogen Species and Tyrosine Nitration in Airway Inflammation......Page 141
S-Nitrosothiols in Lung Inflammation......Page 163
Contribution of Nitric Oxide Synthase Isoforms to Allergen-Induced Airway Hyperresponsiveness and Inflammation......Page 183
Molecular Mechanisms of Increased Nitric Oxide in Airway Inflammation......Page 207
Regulation of Nitric Oxide Synthesis by Inducible Nitric Oxide Synthase......Page 221
Novel Strategies for Selective Inhibition of Inducible Nitric Oxide Synthase......Page 239
Leukocyte Recruitment in Allergic Pulmonary Inflammation......Page 263
Neutrophil Emigration in the Lungs......Page 289
Dendritic Cells......Page 321
Roles of Mast Cells in Airway Hyperreactivity, Inflammation and Remodeling, and Immunoregulation in Asthma......Page 339
Mast Cell Exocytosis in Airway Inflammation......Page 367
Mast Cell Proteases......Page 389
Peroxidases and Asthma......Page 413
Chemokines in Allergic Airway Inflammation......Page 437
Role of the Eotaxin Subfamily of Chemokines in Allergic Eosinophilic Inflammation......Page 461
Interleukin-4 and Interleukin-13 in Human and Experimental Asthma......Page 505
Interleukin-5 and Eosinophils as Therapeutic Targets for the Treatment of Asthma......Page 519
Modulating the Interleukin-5 Response in Asthma......Page 535
The Role of Interleukin-9 in Allergic Inflammation of Asthma......Page 559
Epithelial Production of IL-12 p80 During Viral Infection and Asthma Supports an Altered Paradigm for Airway Inflammation......Page 575
Interleukin-16 and Airway Hyperresponsiveness in Asthma......Page 603
Modulation of the Allergic Response......Page 621
Inhibition of Cytokine Signaling......Page 639
Eicosanoids as Mediators and Therapeutic Targets in Airway Inflammation......Page 667
Nitric Oxide, Reactive Nitrogen Species, and Lipid Mediator Generation in the Lung......Page 697
Adenosine Signaling and Lung Inflammation......Page 721
Complement Factor 5 in Asthma......Page 739
Complement Anaphylatoxin Receptors in Asthma......Page 755
Inflammatory and Structural Changes in Airway Remodeling of Asthma......Page 763
The Role of Proteases in Airway Remodeling......Page 789
Airway Smooth Muscle......Page 807
Cellular Trafficking of  Beta2-Adrenergic Receptors......Page 821
Genetic Targets in Asthma......Page 837
Application of Pharmacogenetics to the Therapeutics of Asthma......Page 863
DNA-Based Immunotherapy for Asthma......Page 879
Allergen Immunotherapy......Page 907
Peptide-Based Therapy for Asthma......Page 931
Reducing IgE Levels as a Strategy for the Treatment of Asthma......Page 947
Strategies to Reduce Excessive Mucus Secretion in Airway Inflammation......Page 963
INDEX......Page 991