Liver Pathology: An Atlas and Concise Guide

Contents......Page 8
Foreword......Page 10
Acknowledgments......Page 12
1 Approach to Liver Specimens, Normal, Minor, and Structural Alterations......Page 14
1.1 Approach to Liver Specimens......Page 15
1.2 Routine and Special Stains......Page 18
1.3 Immunohistochemisty......Page 22
1.4 Molecular Studies and Electron Microscopy......Page 27
1.5 Normal Liver......Page 29
1.6 Hepatocyte Degeneration, Death, and Regeneration......Page 32
1.7 Nonspecific Reactive Hepatitis, Mild Acute Hepatitis, and Residual Hepatitis......Page 34
1.8 Portal and Vascular Problems......Page 37
1.9 Brown Pigments in the Liver......Page 40
2 Acute Liver Diseases......Page 44
2.1 Acute Hepatitis......Page 45
2.2 Acute Hepatotropic Viral Hepatitis......Page 48
2.3 Acute Nonhepatotropic Viral Hepatitis......Page 51
2.4 Acute Hepatitis With Massive Hepatic Necrosis......Page 54
2.5 Granulomatous Inflammation......Page 57
2.6 Acute Cholestasis......Page 60
2.7 Alcoholic Hepatitis......Page 63
2.8 Drug-Induced Liver Injury......Page 66
2.9 Bacterial, Fungal, and Parasitic Infection......Page 72
2.10 Sepsis......Page 77
2.11 Large Bile Duct Obstruction......Page 80
2.12 Liver Disease in Pregnancy......Page 83
3 Chronic Liver Disorders......Page 86
3.1 Chronic Hepatitis......Page 87
3.2 Chronic Viral Hepatitis......Page 90
3.3 Grading and Staging of Chronic Viral Hepatitis......Page 94
3.4 Nonalcoholic Fatty Liver Disease......Page 97
3.5 Alcoholic Liver Disease......Page 100
3.6 Autoimmune Hepatitis......Page 103
3.7 Primary Biliary Cirrhosis......Page 106
3.8 Primary Sclerosing Cholangitis......Page 109
3.9 Overlap Syndromes......Page 112
3.10 Chronic Drug-Induced Injury......Page 114
3.11 Hereditary Metabolic Diseases......Page 118
3.12 Diagnosis of Cirrhosis......Page 122
3.13 Fibropolycystic Disease of the Liver......Page 127
3.14 Outflow Problem......Page 130
3.15 Intracytoplasmic Inclusions......Page 133
4 Transplant Liver Disorders......Page 138
4.1 Donor Liver Evaluation......Page 139
4.2 Preservation Injury......Page 142
4.3 Vascular and Biliary Tract Complications......Page 145
4.4 Acute Rejection......Page 148
4.5 Chronic Rejection......Page 151
4.6 Acute Hepatitis......Page 154
4.7 Recurrent Diseases......Page 156
4.8 Immune-Mediated Hepatitis and Other Findings in Late Posttransplant Biopsies......Page 160
4.9 Opportunistic Infections......Page 162
4.10 Posttransplant Lymphoproliferative Disorder......Page 164
4.11 Bone Marrow Transplantation......Page 167
5 Focal Lesions and Neoplastic Diseases......Page 170
5.1 Hepatic Granulomas......Page 171
5.2 Ductular Proliferative Lesions......Page 175
5.3 Cysts of the Liver......Page 178
5.4 Hepatic Abscess, Inflammatory Pseudotumor, and Hydatid Cysts......Page 181
5.5 Benign Hepatocellular Tumors......Page 184
5.6 Nodules in Cirrhosis......Page 190
5.7 Hepatocellular Carcinoma......Page 194
5.8 Cholangiocarcinoma......Page 200
5.9 Vascular Lesions......Page 205
5.10 Lipomatous Lesions......Page 209
5.11 Other Mesenchymal Tumors......Page 212
5.12 Lymphoma and Leukemia......Page 214
5.13 Metastatic Tumors......Page 218
5.14 Tumor-Associated Changes......Page 222
6 Pediatric Liver Diseases......Page 224
6.1 Pediatric Liver Biopsy......Page 225
6.2 Neonatal Hepatitis Syndrome......Page 228
6.3 Extrahepatic Biliary Atresia and Paucity of Intrahepatic Bile Duct......Page 231
6.4 Fatty Liver Disease......Page 235
6.5 Total Parenteral Nutrition–Induced Cholestatic Liver Disease......Page 238
6.6 Congenital Hepatic Fibrosis......Page 241
6.7 Progressive Familial Intrahepatic Cholestasis......Page 244
6.8 Hereditary and Metabolic Liver Disorder......Page 247
6.9 Pediatric Liver Tumors......Page 251
Suggested Readings......Page 256
B......Page 268
D......Page 269
I......Page 270
M......Page 271
Q......Page 272
Y......Page 273