Leucocyte Typing: Human Leucocyte Differentiation Antigens Detected by Monoclonal Antibodies. Specification — Classification — Nomenclature

Front Matter....Pages I-XVII
Introductory Remarks....Pages 1-2
The Impact of Monoclonal Antibodies on Studies of the Differentiation of Lymphocytes....Pages 3-8
Joint Report of the First International Workshop on Human Leucocyte Differentiation Antigens by the Investigators of the Participating Laboratories....Pages 9-142
Rapports des études communes par les chercheurs des laboratoires participants au premier atelier international sur les antigènes de différenciation leucocytaire....Pages 143-192
Front Matter....Pages 193-193
Human T Lymphocyte Cell Surface Molecules Defined by the Workshop Monoclonal Antibodies (“T Cell Protocol”)....Pages 195-212
Analysis of T Lymphocyte Antibody Specificities: Comparison of Serology with Immunoprecipitation Patterns....Pages 212-223
Analysis of the T Cell-Specific Sets of Monoclonal Antibodies....Pages 224-231
Reactivity of Monoclonal Anti-T Workshop Reagents in Immunofluorescence and Cytotoxicity Techniques....Pages 231-236
Monoclonal Antibodies Against T Cells as Interferon Inducers....Pages 236-240
Cytotoxic Analysis of Workshop Anti-T Cell Antisera....Pages 241-247
Biochemical Analysis of Human Thymus Leukemia-Like Antigens....Pages 248-256
Diversity of Class I Molecules Heavy and Light Chains on Human Thymus Cells....Pages 257-272
Acquisition of a Novel T Cell Surface Protein During Intrathymic T Cell Maturation Encoded for by the Short Arm of Chromosome 11....Pages 272-277
Cell Surface Antigens on Human Leucocytes Defined by Murine Monoclonal Antibodies....Pages 278-281
Phenomenon of Rosette Formation of Human T Cells Analyzed with Monoclonal Antibodies. The Same Mechanism of Interaction Accounts for Rosette Formation with Erythrocytes from Many Species, Including Autologous Erythrocytes....Pages 281-293
Reactivity of the Anti-Human T Cell Monoclonal Antibodies Submitted to the Workshop on One Anti-Class I and One Anti Class II Cytotoxic T Cell Clone....Pages 294-297
Phenotype of Prothymocytes from Human Bone Marrow Determined by Monoclonal Antibodies: Modification Induced by Thymic Factors....Pages 298-303
Characterization of Functional Human T Cell Subsets by Monoclonal Antibodies....Pages 303-311
Analysis of Two Monoclonal Antibodies Defining the Majority and a Subset of Human T Cells....Pages 312-315
Identification and Characterization of a Suppressor T Cell Subpopulation with Monoclonal Antibodies....Pages 316-319
Front Matter....Pages 193-193
Inhibition of Virus-Specific, HLA-Restricted, T Cell-Mediated Lysis by Monoclonal Anti-T Cell Antibodies....Pages 320-328
Monoclonal Antibodies Specific for B Cells, Cytotoxic/Suppressor T Cells, and a Subset of Cytotoxic/Suppressor T Cells in the Rhesus Monkey....Pages 328-336
Front Matter....Pages 337-337
Human B Cell and B Cell Blast-Associated Surface Molecules Defined with Monoclonal Antibodies....Pages 339-346
B Cells and Kidneys: A “B + CALLA” Workshop Analysis....Pages 346-353
Human B Cell-Associated Antigens: Expression on Normal and Malignant B Lymphocytes....Pages 354-363
The Human B Cell Lineage Studied with Monoclonal Antibodies....Pages 363-371
Surface Antigens of Subpopulations of Mitogen-Stimulated Human Lymphocytes....Pages 372-375
Human B Cell Lymphomas Studied with a Set of Monoclonal Antibodies Raised Against B Lymphoma Cells....Pages 376-383
Front Matter....Pages 385-385
Membrane Antigens of Human Myeloid Cells Defined by Monoclonal Antibodies....Pages 387-394
Expression of Granulopoietic Differentiation Markers in the K562 Cell Line....Pages 395-397
Stages of Myeloid Differentiation Identified by Monoclonal Antibodies....Pages 398-404
Expression of Myeloid Differentiation Antigens in Acute Myeloblastic Leukemia....Pages 404-410
Human Myeloid Differentiation Studied by Monoclonal Antibodies....Pages 410-419
Serological and Biochemical Characterization of Human Myeloid-Associated Antigens and Their Expression in Human-Mouse Cell Hybrids....Pages 419-423
Human Myelomonocytic Differentiation Antigens Defined by Monoclonal Antibodies....Pages 424-433
Human Mononuclear Phagocyte Differentiation Antigens: Definition by Monoclonal Antibodies, Cell Distribution, and In Vitro Modulation....Pages 434-437
Cellular Specificity and Functional Studies of G2: A Monoclonal Antibody to Human Polymorphonuclear Leucocytes....Pages 438-442
Changes in Cell Surface Antigen Expression During Myelocytic and Monocytic Cell Differentiation....Pages 442-446
On the Bone Marrow Origin of the Human Mast Cell: In Vitro Growth and Characterization of Human Malignant Mast Cells....Pages 446-450
Front Matter....Pages 451-451
Immunocytochemical Characterization of Monoclonal Anti-Leucocyte Antibodies....Pages 453-465
Front Matter....Pages 451-451
Use of Tissue Distribution Studies to Determine the Specificity of Monoclonal Antilymphocyte Antibodies....Pages 465-469
Comparative Analysis of Monoclonal Antibodies of Workshop T Series on Suspensions and Tissue Sections....Pages 469-475
Importance of Tissue Localization in Characterization of Monoclonal Antibodies to Human Leucocyte Antigens....Pages 475-480
Analysis of B Cell-CALLA and Monocyte-Granulocyte Protocol Reagents Using Immunofluorescence, Tissue Sections (PAP) and Molecular Weight Determination....Pages 481-487
Analysis of Monoclonal Antibody Binding Using Stepwise-Amplified Immunoperoxidase Staining....Pages 488-492
Immunohistochemical Studies with Monoclonal Antibodies to Differentiation, Cell Lineage and Site-Specific Surface Antigens of Human Mononuclear Phagocytes....Pages 493-499
Front Matter....Pages 501-501
Studies on the Biochemistry of the Peptides Bearing the Human Leucocyte Common Epitope Recognized by the Monoclonal Antibody MID 2....Pages 503-507
Studies on the Distribution Among T Lymphocytes of the High-Molecular-Weight Form of the Human Leucocyte Common Antigen....Pages 507-516
Front Matter....Pages 517-517
A Scheme of Human Hematopoietic Differentiation Based on the Marker Profiles of the Cultured and Fresh Leukemia-Lymphomas: The Result of Workshop Study....Pages 519-527
Phenotypic T Cell Antigens of Adult T Cell Leukemia in Japan....Pages 528-533
Immunologic Phenotype of Tumor Cells from Japanese T Cell Malignancies....Pages 534-537
Differential Expression of Human T-ALL-Associated Antigens Detected by Two Murine Monoclonal Antibodies....Pages 537-543
Occurrence of T-Cell Features in a Child’s Lymphoproliferative Disorder....Pages 543-546
Differences in Antigen Expression on Normal Thymocytes and on Cells Derived from Hyperplastic Thymi and Thymoma of Myasthenia Gravis Patients....Pages 546-552
Characterization of Lymphocytes in Tissue Lesions from Patients with Rheumatoid Arthritis and Sjögren’s Syndrome Using Monoclonal Antibody SC1....Pages 552-557
Phenotypes of Adult Acute Lymphoblastic Leukemia Defined by Monoclonal Antibodies....Pages 558-564
Diagnostic Value of Monoclonal Antibodies to Leucocyte — Differentiation Antigens in Lymphoid and Nonlymphoid Leukemias....Pages 564-573
A Monoclonal Antibody (WBH-H7) Identifying “Non-CALLA” Acute Lymphoblastic Leukemias?....Pages 573-579
Surface Phenotype and Cell Kinetics in Leukemias and Lymphomas....Pages 579-587
Serological Typing of Acute Leukemia Using the Monoclonal Antibodies PHM 1, 2, 3, 6, CIKM5, and the Rabbit Antisera RARC2a (Ad) and RAALLP50....Pages 588-595
Front Matter....Pages 517-517
Hybridoma Antibodies to Leukemia-Associated Antigens of Childhood Acute Lymphocytic Leukemia (ALL)....Pages 596-599
Induction of Differentiation in B Cell Leukemia....Pages 599-603
Immunological Classification of Leukemias with Monoclonal Antibodies....Pages 603-608
Transitional Pre-B to B Acute Lymphoblastic Leukemia....Pages 608-614
Use of a Monoclonal Antihuman B-Cell Antibody in Diagnosis and Therapy of Non-Hodgkin’s Lymphoma....Pages 614-618
Front Matter....Pages 619-619
Multiparameter Approaches to FACS Analysis of Human Leucocyte Cell Surface Antigens....Pages 621-630
Detection of Monoclonal Antibodies to Leucocytes Using the Solid-Phase Mixed Passive Hemagglutination Technique....Pages 631-636
Front Matter....Pages 637-637
A Discussion of T Cell Development in Mice and Men, or What Happened to the Lyt 123 Cell in Man and Other Questions....Pages 639-645
A Re-Viewing of Thymocyte Differentiation....Pages 645-650
What Happened to Lineage-and Leukemia-Specific Antigens? Implications for Therapeutic Use of Monoclonal Antibodies....Pages 651-656
Specificity Revisited....Pages 656-661
On the Stability of T Cell Differentiation Antigens....Pages 661-664
A Microculture Method for Production of Monoclonal Antibodies....Pages 664-665
Front Matter....Pages 667-667
Leucocyte Malignancies....Pages 669-694
Expression and Characterization of Leucocyte Antigens....Pages 694-724
Lymphocyte Functions....Pages 724-736
Techniques for Characterization of Leucocyte Antigens and Utilization of Antibodies in Therapy....Pages 737-750
Back Matter....Pages 751-814