Lessons from Animal Diabetes VI: 75th Anniversary of the Insulin Discovery

Front Matter....Pages i-xiii
Expression of glutamic acid decarboxylase (GAD) and its role as an autoantigen in insulin-dependent diabetes....Pages 1-32
Molecular genetics of insulin-dependent diabetes mellitus: Analysis of congenic strains....Pages 33-46
Role of macrophages and cytokines in B-cell death....Pages 47-56
Immunotherapy of insulin-dependent diabetes mellitus: Tolerance after short-term anti—;IL-2 receptor/cyclosporine therapy in BB/OK rats....Pages 57-76
Role of retroviruses in the pathogenesis of diabetes with emphasis on the NOD mouse....Pages 77-82
Occurrence of pretype I diabetes (pre-IDDM) and type II diabetes (NIDDM) in BC1 [(NOD x Mus spretus) F1 x NOD] mice....Pages 83-95
Okamoto model for B-cell damage: Recent advances....Pages 97-111
Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan....Pages 113-122
Role of glucokinase in regulation of insulin secretion: Lessons from transgenic mice....Pages 123-130
Consequences of human IAPP expression in transgenic mice....Pages 131-148
Immunostimulatory versus immunosuppressive roles of IL-10 in IDDM: Analysis with IL-10—Producing transgenic NOD mice....Pages 149-173
Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase....Pages 175-200
Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity....Pages 201-224
Spontaneously diabetic rat “OLETF” as a model for NIDDM in humans....Pages 225-236
Glucose and lipid metabolism in the gold thioglucose injected mouse model of diabesity....Pages 237-265
Diabetes in the Chinese hamster....Pages 267-298
Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat....Pages 299-315
Role of immune and non-immune aspects of genetics in different expressions of diabetes in db/db mice....Pages 317-332
Inositols—Potential roles in insulin action and in diabetes: Evidence from insulin-resistant nonhuman primates....Pages 333-348
Antidiabetic characteristics of dehydroepiandrosterone in animal and human studies....Pages 349-373
Endoneurial vessel abnormalities in diabetic animal models....Pages 375-393
Dog and rat models of diabetic retinopathy....Pages 395-408
Glucose homeostasis in three interstrains (LA/N-BN/Crl cp/cp; Zuc13M-BN/Crl fa/fa; and Zuc13m-LA/N fa/cp) of genetically obese rats....Pages 409-416
Back Matter....Pages 417-420