LC-MS in Drug Analysis: Methods and Protocols

Front Matter ....Pages i-x
 An Introduction to Drug Testing: The Expanding Role of Mass Spectrometry  (Christine L. H. Snozek, Loralie J. Langman, Steven W. Cotten)....Pages 1-10
 Quantification of Eight Cannabinoids Including Cannabidiol in Human Urine Via Liquid Chromatography Tandem Mass Spectrometry  (Karl B. Scheidweiler, Allan J. Barnes)....Pages 11-22
 Analysis of Benzodiazepines for Drug-Facilitated Assaults and Abuse Settings (Urine)  (Olaf H. Drummer, Matthew Di Rago, Dimitri Gerostamoulos)....Pages 23-39
 Targeted Opioid Screening Assay for Pain Management Using High-Resolution Mass Spectrometry  (Darlington Danso, Loralie J. Langman, Paul J. Jannetto)....Pages 41-50
 Measurement of Buprenorphine and Norbuprenorphine in Urine  (Andrea R. Terrell, Vipin Adhlakha, Poluru Reddy)....Pages 51-59
 Quantitation of Tapentadol by Liquid Chromatography: Tandem Mass Spectrometry  (Graham R. Jones, Russell P. Handy)....Pages 61-65
 Therapeutic Drug Monitoring of Lacosamide by LC-MS/MS  (He Sarina Yang, Leslie Edinboro)....Pages 67-73
 LC-MS/MS Method for the Quantification of the Leflunomide Metabolite, Teriflunomide, in Human Serum/Plasma  (Geoffrey S. Rule, Alan L. Rockwood, Kamisha L. Johnson-Davis)....Pages 75-83
 Analysis of Tryptic Peptides from Therapeutic Monoclonal Antibodies Using LC-MS/MS  (Maria Alice V. Willrich)....Pages 85-99
 Quantification of Methotrexate in Human Serum and Plasma by Liquid Chromatography Tandem Mass Spectrometry  (Gabrielle N. Winston-McPherson, Michael Schmeling, Andrew N. Hoofnagle)....Pages 101-110
 Simultaneous Determination of Tacrolimus and Cyclosporine A in Whole Blood by Ultrafast LC-MS/MS  (Matthew W. Bjergum, Paul J. Jannetto, Loralie J. Langman)....Pages 111-118
 Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method to Quantify Gabapentin and Pregabalin in Urine  (Stephen Merrigan, Kamisha L. Johnson-Davis)....Pages 119-127
 The Evolving Landscape of Designer Drugs  (Sherri L. Kacinko, Donna M. Papsun)....Pages 129-135
 Analysis of Synthetic Cannabinoid Metabolites by Liquid Chromatography-Tandem Mass Spectrometry  (Gregory C. Janis)....Pages 137-147
 Quantification of Designer Opioids by Liquid Chromatography–Tandem Mass Spectrometry  (Sherri L. Kacinko, Joseph W. Homan)....Pages 149-163
 Screening Analysis for Designer Stimulants by LC-MS/MS  (Piotr Adamowicz, Bogdan Tokarczyk)....Pages 165-180
 Drug Screening Using Liquid Chromatography Quadrupole Time-of-Flight (LC-QqTOF) Mass Spectrometry  (Jennifer M. Colby, Kara L. Lynch)....Pages 181-190
 Alternate Matrices: Meconium, Cord Tissue, Hair, and Oral Fluid  (Kendra L. Palmer, Matthew D. Krasowski)....Pages 191-197
 Salt-Assisted Liquid-Liquid Extraction of Meconium for Analysis of Cocaine and Amphetamines by Liquid Chromatography-Tandem Mass Spectrometry  (Melissa M. Goggin, Gregory C. Janis)....Pages 199-209
 Detection of In Utero Cannabis Exposure in Umbilical Cord Tissue by a Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method  (Fang Wu, Triniti L. Jensen, Gwendolyn A. McMillin)....Pages 211-222
 Quantitation of Ethyl-β-d-Glucuronide in Human Umbilical Cord Tissue by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)  (Simuli L. Wabuyele, Gwendolyn A. McMillin)....Pages 223-236
 Analysis of Drugs in Oral Fluid Using LC-MS/MS  (Cynthia A. Coulter, Christine M. Moore)....Pages 237-259
 Determination of Cocaine and Metabolites in Dried Blood Spots by LC-MS/MS  (Lars Ambach, Christophe Stove)....Pages 261-272
Back Matter ....Pages 273-274