Lacrimal Gland, Tear Film, and Dry Eye Syndromes: Basic Science and Clinical Relevance

Front Matter....Pages i-xxii
Regulation of Tear Secretion....Pages 1-9
The Anatomy and Innervation of Lacrimal Glands....Pages 11-18
Light and Electron Microscopic Morphology of Accessory Lacrimal Glands....Pages 19-23
Immunohistochemistry and Protein Secretion in the Rat Lacrimal Gland: a Morphophysiological Study....Pages 25-30
Carbonic Anhydrase and Acinar Cell Heterogeneity in Rat and Rabbit Lacrimal Glands....Pages 31-36
Basement Membrane Modulation of Stimulated Secretion by Lacrimal Acinar Cells....Pages 37-44
Galactose-Binding Sites in the Acinar Cells of the Human Accessory Lacrimal Gland....Pages 45-48
Thoughts on the Ductules of the Aging Human Lacrimal Gland....Pages 49-52
The Parenchyma Accompanying Major Extraglandular Ducts within the Rat Lacrimal Cord....Pages 53-56
Protein Secretion and the Identification of Neurotransmitters in the Isolated Pig Lacrimal Gland....Pages 57-60
Anti-Muscarinic Acetylcholine Receptor-Like Immunoreactivity in Lacrimal Glands....Pages 61-65
Innervation and Mast Cells of the Rat Lacrimal Gland: the Effects of Age....Pages 67-74
Immunogold Localization of Prolactin in Acinar Cells of Lacrimal Gland....Pages 75-77
Subcellular Organization of Ion Transporters in Lacrimal Acinar Cells: Secretagogue-Induced Dynamics....Pages 79-86
Effect of Acetylcholine on the Membrane Conductance of the Intralobular Duct Cells of the Rat Exorbital Lacrimal Gland....Pages 87-92
The Circadian Rhythm of Lacrimal Secretion and its Parameters, Determined in a Group of Healthy Individuals, and its Potential Diagnostic and Therapeutic Significance....Pages 93-97
Effects of Dihydrotestosterone and Prolactin on Lacrimal Gland Function....Pages 99-104
A Na:H Exchanger Subtype Mediates Volume Regulation in Bovine Corneal Epithelial Cells....Pages 105-110
Endocytosis and Exocytosis in Rabbit Lacrimal Gland Acinar Cells....Pages 111-114
The Inositol Phosphate-Calcium Signalling System in Lacrimal Gland Cells....Pages 115-119
Characterization of Rat Lacrimal Gland Protein Kinase C: Effects of Phorbol Esters and PKC Inhibitors on Histone Kinase Activity and Labelled Protein Discharge....Pages 121-125
Inhibition of Lacrimal Function by Selective Opiate Agonists....Pages 127-132
Second Messenger Modulation of IgG Secretion from Chicken Lacrimal Gland....Pages 133-139
Identification of Sigma Receptors in Lacrimocytes and their Therapeutic Implication in Dry Eye Syndrome....Pages 141-146
Role of Protein Kinase C in α 1 -Adrenergic and Cholinergic Agonist Stimulated Protein Secretion....Pages 147-150
The Role of Membrane Channels in IgG Secretion by Plasma Cells in the Chicken Lacrimal Gland....Pages 151-156
Binding Characteristics, Immunocytochemical Location and Hormonal Regulation of Androgen Receptors in Lacrimal Tissue....Pages 157-160
Regulation of Lacrimal Gland Immune Responses....Pages 161-168
The Lacrimal Antibody Response to Viral and Chlamydial Infections....Pages 169-174
Neural-Endocrine Control of Secretory Component Synthesis by Lacrimal Gland Acinar Cells: Specificity, Temporal Characteristics and Molecular Basis....Pages 175-180
Lymphocyte Adhesive Interaction with Lacrimal Gland Acinar Epithelium Involves Carbohydrate Recognition....Pages 181-184
Subclass Expression of IgA in Lacrimal Glands of Patients with Sjögren’s Syndrome....Pages 185-188
Influence of the Endocrine Environment on Herpes Virus Infection in Rat Lacrimal Gland Acinar Cells....Pages 189-192
Sialodacryoadenitis Virus Infection of Rat Lacrimal Gland Acinar Cells....Pages 193-196
Growth Factor and Receptor Messenger RNA Production in Human Lacrimal Gland Tissue....Pages 197-204
Human Lacrimal Gland Secretes Proteins Belonging to the Group of Hydrophobic Molecule Transporters....Pages 205-210
Transcription of Message for Tumor Necrosis Factor-alpha by Lacrimal Gland is Regulated by Corneal Wounding....Pages 211-217
Androgen Regulation of Secretory Component mRNA Levels in the Rat Lacrimal Gland....Pages 219-224
Vasoactive Intestinal Peptide Induces Primary Response Gene Expression in Lacrimal Gland....Pages 225-230
Composition and Biophysical Properties of the Tear Film: Knowledge and Uncertainty....Pages 231-238
Structure and Function of the Tear Film....Pages 239-247
Ocular Surface Changes Induced by Repeated Impression Cytology....Pages 249-254
Developmental Appearance of a Component of the Glycocalyx of the Ocular Surface Epithelium in the Rat....Pages 255-261
Mixing of the Tear Film Under the Eyelids....Pages 263-266
Viscoelastic Properties of Human Tears and Polymer Solutions....Pages 267-270
Effect of Age on Human Tear Film Evaporation in Normals....Pages 271-274
Advances in Ocular Tribology....Pages 275-283
Effect of Systemic Ingestion of Vitamin and Trace Element Dietry Supplements on the Stability of the Pre-Corneal Tear Film in Normal Subjects....Pages 285-287
Patterns of Cytokeratin Expression in Impression Cytology Specimens from Normal Human Conjunctival Epithelium....Pages 289-292
Increase in Tear Film Lipid Layer Thickness Following Treatment of Meibomian Gland Dysfunction....Pages 293-298
Analysis and Function of the Human Tear Proteins....Pages 299-308
Tear Protein Composition and the Effects of Stimulus....Pages 309-314
Growth Factors in Human Tear Fluid and in Lacrimal Glands....Pages 315-319
Re-Examination of the Origin of Human Tear LDH....Pages 321-326
Tear Proteins and Enzymes in the Chimpanzee....Pages 327-330
Comparisons of Tear Proteins in the Cow, Horse, Dog and Rabbit....Pages 331-334
Tear Protein G Originates from Denatured Tear Specific Prealbumin as Revealed by Anti-Tsp Antibody....Pages 335-338
Tear Lactoferrin Levels and Ocular Bacterial Flora in HIV Positive Patients....Pages 339-344
Vitronectin in Human Tears — Protection Against Closed Eye Induced Inflammatory Damage....Pages 345-349
Mucopolysaccharide Degrading Enzymes (MPDE) in the Tear Fluid: A New Diagnostic Test For Rapid Detection of Acute Ocular Infections....Pages 351-354
Tear Immunoglobulins and Lysozyme Levels in Corneal Ulcers....Pages 355-358
Mucus and Pseudomonas Aeruginosa Adherence to the Cornea....Pages 359-362
Measurement of Human Tear Lysozyme Using a Novel Synthetic Substrate....Pages 363-366
Retrospective Use of Frozen Schirmer Strips for the Measurement of Tear Lysozyme....Pages 367-370
Rapid Measurement of Selected Tear Proteins in Health and Disease Using the Touch Tear Microassay System....Pages 371-375
The Tear Film: Pharmacological Approaches and Effects....Pages 377-384
Influence of Various Pharmaceutical Agents on Tear Flow as Assessed by Fluorophotometry....Pages 385-391
Neural Stimulation of Conjunctival Goblet Cell Mucous Secretion in Rats....Pages 393-398
Bioavailability of Prednisolone in Rabbits: Comparison of a High-Viscosity Gel and An Aqueous Suspension—Single- and Repeated Applications....Pages 399-402
Tear Film — Contact Lens Interactions....Pages 403-410
Electrophoretic Patterns of Human Denatured Tear Proteins and Glycoproteins from Normal Subjects and Soft Contact Lens Wearers....Pages 411-416
The Refractive Index of Tears in Normals and Soft Lens Wearers....Pages 417-420
The Role of Tear Deposits on Hydrogel Contact Lenses Induced Bacterial Keratitis: Pseudomonas aeruginosa Abhesives....Pages 421-426
The Closed-Eye Challenge....Pages 427-430
Dry Eye Therapy: Evaluation of Current Directions and Clinical Trials....Pages 431-431
Artificial Tear Issues....Pages 437-440
Evaluation of Effects of a Physiologic Artificial Tear on the Corneal Epithelial Barrier: Electrical Resistance and Carboxyfluorescein Permeability....Pages 441-452
Evaluation of a Physiological Tear Substitute in Patients with Keratoconjunctivitis Sicca....Pages 453-457
A Scanning Electron Micrographic Comparison of the Effects of Two Preservative-Free Artificial Tear Solutions on the Corneal Epithelium as Compared to a Phosphate Buffered Saline and a 0.02% Benzalkonium Chloride Control....Pages 459-464
A Unique Therapeutic Artificial Tear Formulation....Pages 465-469
Non-Sjögren Dry Eye: Pathogenesis Diagnosis and Animal Models....Pages 471-488
Abnormalities of the Structure of the Superficial Lipid Layer on the in Vivo Dry-Eye Tear Film....Pages 489-493
Tear Osmolarity — A New Gold Standard?....Pages 495-503
Micropachometric Differentiation of Dry Eye Syndromes....Pages 505-512
Decreased Tear Secretion in Chernobyl Children: External Eye Disorders in Children Subjected to Long-Term Low-Dose Radiation....Pages 513-516
Lacrimal Dysfunction in Pediatric Acquired Immunodeficiency Syndrome....Pages 517-520
Keratoconjunctivitis Sicca in HIV-1 Infected Female Patients....Pages 521-523
The Increase of the Blink Interval in Ophthalmic Procedures....Pages 525-527
Changes in Tear Ion Concentrations in Dry-Eye Disorders....Pages 529-533
Quantitative Cellular Evaluation of Conjunctival Squamous Metaplasia in the Dry Eye Patient....Pages 535-538
Topical Anesthetic Induced Pain as a Diagnostic Tool for Kerato Conjunctivitis Sicca (KCS)....Pages 539-542
Lacrimation Kinetics as Determined by a Schirmer-Type Technique....Pages 543-548
A Precise Method of Using Rose Bengal in the Evaluation of Dry Eye and the Detection of Changes in its Severity....Pages 549-552
Dry Eye Syndromes: Treatment and Clinical Trials....Pages 553-559
Keratoprosthesis in End-Stage Dry Eye....Pages 561-564
Amylase in Mare Lacrimale in Patients with Submandibular Salivary Gland Transplantation to the Lacrimal Basin....Pages 565-570
A Subjective Approach to the Treatment of Dry Eye Syndrome....Pages 571-576
Simulation of Lacrimal Gland Output: A Tear Jet for Replacing Eye Moisture in Sjögren’s Syndrome....Pages 577-582
Characteristics of a Canine Model of KCS: Effective Treatment with Topical Cyclosporine....Pages 583-594
Treatment of Severe Eye Dryness and Problematic Eye Lesions with Enriched Bovine Colostrum Lactoserum....Pages 595-599
The Efficiency of Short-Wave Diathermy and Laser Stimulation of the Lacrimal Gland in the Treatment of Dry Eye Syndrome....Pages 601-604
Effect of Collagen Punctal Occlusion on Tear Stability and Volume....Pages 605-608
Sjögren’s Syndrome: Immunologic and Neuroendocrine Mechanisms....Pages 609-621
Murine Models of Sjögren’s Syndrome....Pages 623-630
Utilization of the Non-Obese Diabetic (NOD) Mouse as an Animal Model for the Study of Secondary Sjögren’s Syndrome....Pages 631-636
Expression of Granzyme A and Perforin in Lacrimal Gland of Sjögren’s Syndrome....Pages 637-640
Epstein-Barr Virus and the Lacrimal Gland Pathology of Sjögren’s Syndrome....Pages 641-646
Sjögren’s Syndrome (SS) and Epstein-Barr Virus (EBV) Reactivation....Pages 647-650
Hypothesis for Autoantigen Presentation and T Cell Activation....Pages 651-654
Gingival Impression: A New Biological Test for Xerostomia in Diagnosis of Sjögren’s Syndrome....Pages 655-659
Sjögren’s Syndrome Diagnosis: A Comparison of Conjunctival and Gingival Impressions and Salivary Gland Biopsy....Pages 661-665
Correlation of Labial Salivary Gland Biopsies with Ocular and Oral Findings in Patients with Sjogren’s Syndrome....Pages 667-670
A Comparative Study Between Tear Protein Electrophoresis and Accessory Salivary Gland Biopsy in Sjögren’s Syndrome....Pages 671-677
Sjögren’s Syndrome — Close to Cause and Cure?....Pages 679-682
Androgen-Induced Suppression of Autoimmune Disease in Lacrimal Glands of Mouse Models of Sjögren’s Syndrome....Pages 683-690
Effect of Sodium Sucrose-Sulfate on the Ocular Surface of Patients with Keratoconjunctivitis Sicca in Sjögren’s Syndrome....Pages 691-696
Comparative Efficacy of Androgen Analogues in Suppressing Lacrimal Gland Inflammation in a Mouse Model (MRL/lpr) of Sjögren’s Syndrome....Pages 697-700
National Sjogren’s Syndrome Association....Pages 701-703
Sjögren’s Syndrome Foundation Inc.....Pages 705-708
Back Matter....Pages 709-729