Laboratory Aspects of Infections

Front Matter....Pages i-xiv
Introductory Comments....Pages 1-6
Control of Antibiotic-Sensitivity Testing in Britain....Pages 7-12
Control of Antibacterial Susceptibility Testing: Standardization and Proficiency Testing in Canada....Pages 13-17
Antibiotic Sensitivity Testing in Australia and New Zealand....Pages 19-31
Problems of Standardization of Media....Pages 33-40
Effects of Medium on the Results of Antimicrobial Sensitivity Testing....Pages 41-46
Influence of Four Commercial Sensitivity Media on in Vitro Activity of Several Antibiotics....Pages 47-54
A Spot Plate Method for Antibiotic-Bacterial Killing Rates....Pages 55-59
Usefulness of Commercially Available Media to MIC-Determinations of Trimethoprim....Pages 61-65
Thymidine and the Assessment of Co-Trimoxazole Action in Liquid Media....Pages 67-70
Antibacterial Susceptibility Testing of Anaerobes....Pages 71-76
Sensitivity Testing of Mixed Infections....Pages 77-80
A Diffusion Disc Susceptibility Test for 5-Fluorocytosine....Pages 81-87
The Susceptibility of Clostridia from the Antarctic Soil to Antibiotics....Pages 89-93
Brief Antibiotic Exposure and Effect on Bacterial Growth....Pages 95-102
Trimethoprim and Rifampicin: In Vitro Activities Separately and in Combination....Pages 103-106
A 125 I-Based Radioimmunoassay for Serum Gentamicin....Pages 107-110
Fluorimetric Assay of Tetracycline Mixtures in Plasma....Pages 111-114
Assay of Antibiotics with Agar Diffusion Technique....Pages 115-124
A New Assay Technique for Antibiotics....Pages 125-131
The Problem of Antibiotic Mixtures in Serum Samples....Pages 133-141
Some Factors Influencing the Assay of Gentamicin....Pages 143-146
Assay of Gentamicin and Tobramycin by a Reliable 2½ Hour Klebsiella Plate Method....Pages 147-153
Punch Hole Method. A Simplified Bio-Assay Technique of Antibiotic Concentrations....Pages 155-158
The Assay of Serum Aminoglycoside Concentrations by the ( 14 C)-Acetyl Transferase Technique....Pages 159-164
Immunochemical Study of the Structural Specificity of an Anti-Gentamycin Antiserum, Useful Also for Radioimmunoassay of Sisomycin....Pages 165-168
Serum Activity Determination as Connecting Link between Experiment and Clinic....Pages 169-175
Animal Models in the Assessment of Antimicrobial Agents: What should We Expect of Them?....Pages 177-181
Local Lesions....Pages 183-189
Intraperitoneal Challenge....Pages 191-196
Endocarditis....Pages 197-204
The Usefulness of Experimental Models of Urinary Tract Infections in the Assessment of Chemotherapeutic Compounds....Pages 205-217
An Animal Model for Intestinal Infections....Pages 219-227
Animal Models in the Assessment of Antimicrobial Agents: Salmonellosis....Pages 229-234
Animal Models and Pharmacokinetics....Pages 235-240
Use of an in Vitro Model of the Urinary Bladder in the Investigation of Bacterial Response to Antibiotics....Pages 241-247
Experimental Intra-Abdominal Sepsis....Pages 249-258
Comparative Effects of Amoxycillin and Ampicillin in the Treatment of Experimental Mouse Infections....Pages 259-266
Model of Pleuropneumonia in Rats....Pages 267-272
Murine Meningoencephalitis Caused by PS. Aeruginosa or KL. Pneumoniae as an Experimental Chemotherapeutic Model....Pages 273-279
Animal Experiments on Current Antibiotics....Pages 281-287
Effect of Carbenicillin on Pseudomonas Infection....Pages 289-293
Comparison of Carfecillin and Carbenicillin on Experimental Urinary Tract Infection....Pages 295-301
Model of Experimental Cystitis in Albino Wistar Rats....Pages 303-309
Pathogenesis of an Experimental Pyelonephritis Model in the Mouse and Its Use in the Evaluation of Antibiotics....Pages 311-316
Chronic E.coli Nephritis in Rats: Model for Assessment of Activity of Antimicrobial Agents....Pages 317-322
Combined Therapy of Anti-Endotoxin(OEP) Antibody and Gentamicin in the Immunosuppressed Mice with Pseudomonas Aeruginosa Infection....Pages 323-330
Investigations on Circulatory Tolerance of Doxycycline (Vibravenous R ) and Rolitetracycline (Reverin R ) in Waking Minipigs....Pages 331-334
An in Vitro Comparison of Sisomicin with Gentamicin and Tobramycin....Pages 335-344
Bacteriological and Clinical Evaluation of Sisomicin, a New Aminoglycoside Antibiotic....Pages 345-354
Pharmacokinetics of Sisomicin in Patients with Renal Impairment....Pages 355-365
Serum and Tissue Levels of Sisomicin in Dogs....Pages 367-374
Sisomicin Treatment of Urinary Tract Infections....Pages 375-387
Parenteral Sisomicin for Surgical Infections....Pages 389-394
Clinical Trial of Sisomycin: Evaluation of Two Different Dosages....Pages 395-401
In Vivo Activity of Sisomicin in Mice....Pages 403-408
New Data on Pharmacology of Gentamycin....Pages 409-415
Bacteriological,Clinical and Pharmacological Investigations with Tobramycin....Pages 417-420
The Urinary Excretion of Tobramycin and Gentamicin....Pages 421-425
Pharmacokinetics and Ototoxicity of Gentamicin, Tobramycin and Amikacin....Pages 427-429
Clinical Experience on Tobramycin....Pages 431-436
Evaluation of Tobramycin in Severe Urinary Tract Infection....Pages 437-439
Butirosin — Pharmacodynamics and Clinical Experience....Pages 441-451
Action Mechanism of 3,4-Dideoxykanamycin B (DKB) on Some Gram-Negative Bacteria....Pages 453-455
Use of 3,4-Dideoxykanamycin B (DKB) in Various Infections....Pages 457-459
Back Matter....Pages 461-462