Kynurenine and Serotonin Pathways: Progress in Tryptophan Research

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Retro-, Intro- and Perspectives of Trypto-Fun....Pages 3-13
Tryptophan and Related Alkaloids....Pages 15-28
Stability of Tryptophan in Peptides Against Oxidation and Irradiation....Pages 29-40
Mass Spectrometric Determinations of Tryptophan and its Metabolites....Pages 41-50
Signal-to-Noise Optimization of HPLC-Fluorometric Systems and their Application to the Analysis of Indoles....Pages 51-61
Brain Indole Metabolism Assessed Using in Vivo Dialysis....Pages 63-80
Sub-Picogram Determination of Serotonin Using HPLC with Electrochemical Detection for Microdialysis Studies of Serotonin Release....Pages 81-89
Front Matter....Pages 91-91
Autoradiographic Measurement of the Rate of Serotonin Synthesis in the Rat Brain....Pages 93-105
Autoradiographic Studies of 5HT 2 Receptors....Pages 107-113
Ambivalence on the Multiplicity of Mammalian Aromatic L-Amino Acid Decarboxylase....Pages 115-125
Interrelationships of DNA Cycles and Melatonin Synthesis....Pages 127-136
Regulation of Melatonin Synthesis in the Ovine Pineal Gland....Pages 137-148
Melatonin Synthesis: Multiplicity of Regulation....Pages 149-158
Front Matter....Pages 159-159
The Role of Tryptophan and Kynurenine Transport in the Catabolism of Tryptophan Through Indoleamine 2,3-Dioxygenase....Pages 161-166
Kynureninase and Kynurenine 3-Hydroxylase in Mammalian Tissues....Pages 167-176
Relationships Between Pteridine Synthesis and Tryptophan Degradation....Pages 177-184
Quinolinic Acid and Kynurenic Acid in the Mammalian Brain....Pages 185-199
Kynurenate Forming Enzymes in Liver, Kidney and Brain....Pages 201-205
Regulation of Pyridine Nucleotide Coenzyme Metabolism....Pages 207-218
Front Matter....Pages 219-219
Serotonin: Its Role and Receptors in Enteric Neurotransmission....Pages 221-230
Front Matter....Pages 219-219
Mechanisms of Serotonergic Affect Control....Pages 231-243
Neuroendocrine Responses to L-Tryptophan as an Index of Brain Serotonin Function: Effect of Weight Loss....Pages 245-254
Melatonin Receptors in the Central Nervous System....Pages 255-265
Melatonin Interaction with the Benzodiazepine-GABA Receptor Complex in the CNS....Pages 267-277
Front Matter....Pages 279-279
Effects of Tryptophan 2,3-Dioxygenase Inhibitors in the Rat....Pages 281-288
Bidirectional Relationships Between Tryptophan and Social Behavior in Vervet Monkeys....Pages 289-298
The Regulation of Brain Kynurenic Acid Content: Focus on Indole-3-Pyruvic Acid....Pages 299-308
Physiological Role of 3-Hydroxykynurenine and Xanthurenic Acid Upon Crustacean Molting....Pages 309-318
Kynurenines in the Regulation of Behavior in Insects....Pages 319-328
Effects of Quinolinic and Kynurenic Acids on Central Neurons....Pages 329-336
Behavioral Abnormalities in Rats after Single Treatment with Quinolinic Acid During Early Ontogenesis....Pages 337-342
Front Matter....Pages 343-343
Tryptophan Nutrition and Metabolism: An Overview....Pages 345-358
Comparison of Tryptophan Metabolism in Vivo and in Isolated Hepatocytes from Vitamin B6 Deficient Mice....Pages 359-368
Effects of the Diet and other Metabolic Phenomena on Brain Tryptophan Uptake and Serotonin Synthesis....Pages 369-376
Effects of Tryptophan and of 5-Hydroxytryptamine Receptor Subtype Agonists on Feeding....Pages 377-388
The Role of Serotonin (5-HT) in Feeding Responses to Amino Acids....Pages 389-404
Front Matter....Pages 405-405
Cardiovascular and Endocrine Properties of L-Tryptophan in Combination with Various Diets....Pages 407-416
Acute Effects of Meals on Brain Tryptophan and Serotonin in Humans....Pages 417-423
Implications of Interferon-Induced Tryptophan Catabolism in Cancer, Autoimmune Diseases and Aids....Pages 425-435
Induction of Indoleamine 2,3-Dioxygenase in Tumor Cells Transplanted into Allogeneic Mouse: Interferon-γ is the Inducer....Pages 437-444
Front Matter....Pages 445-445
Plasma Free 5HT, Plasma 5HIAA and Whole Blood 5HT in the Rat....Pages 447-450
Effects of Clomipramine on Extracellular Serotonin in the Rat Frontal Cortex....Pages 451-454
Tryptophan Metabolism in Senile Cataract Patients Assessed by High-Performance Liquid Chromatography....Pages 455-457
The Effect of Aluminum on Rat Brain and Liver Quinolinic Acid Concentrations....Pages 459-462
Kynurenine and Lipid Metabolism....Pages 463-466
Content of Tryptophan in Human Hair....Pages 467-470
Detection of a New Intermediate Product of Indolealkylamine Metabolism in the Brain....Pages 471-473
The Excretion of N 1 -Methyl-2-Pyridone-5-Carboxylic Acid and Related Compounds in Human Subjects after Oral Administration of Nicotinic Acid, Trigonalline and N 1 -Methyl-2-Pyridone-5-Carboxylic Acid....Pages 475-479
Stable Isotope-Labeled Tryptophan as a Precursor for Studying the Disposition of Quinolinic Acid in Rabbits....Pages 481-484
Evidence for the Preferential Production of 3-Hydroxyanthranilic Acid from Anthranilic Acid in the Rat Brain....Pages 485-488
Chronobiological Effects of L-Tryptophan in Humans: Influence on Melatonin Secretion....Pages 489-491
Circadian Patterns of Salivary Melatonin and Urinary 6-Sulfatoxy-Melatonin before and after A 9 Hour Time-Shift....Pages 493-496
Tryptophan Metabolism in Mice Infected with Schistosoma Mansoni ....Pages 497-500
Inhibition of Tryptophan → Niacin Metabolism by Dietary Leucine and by Leucine and 2-Oxo-isocaproate in vitro....Pages 501-504
Induction of Indoleamine 2,3-Dioxygenase in Human Cells in Vitro....Pages 505-509
Differential Effects of Estradiol and Hydrocortisone on Liver Tryptophan Pyrrolase in Rats of Various Ages....Pages 511-514
Indole-3-Pyruvic Acid as a Direct Precursor of Kynurenic Acid....Pages 515-518
Tryptophan Metabolism in Healthy Subjects: Influence of Pyridoxine after Single or Repeated Administrations....Pages 519-522
On Kynureninase Activity....Pages 523-526
Rat Skin Tryptophan 2,3-Dioxygenase....Pages 527-529
Front Matter....Pages 445-445
Kynurenine 3-Monooxygenase Activity of Rat Brain Mitochondria Determined by High Performance Liquid Chromatography with Electrochemical Detection....Pages 531-534
Indolic and Kynurenine Pathway Metabolites of Tryptophan in Rat Brain: Effect of Precursor Availability on in Vivo Release....Pages 535-539
Kinetic Properties of Human Liver Tryptophan Pyrrolase....Pages 541-545
Interferon Type I and II Antagonism: A Novel Regulatory Mechanism of Indoleamine Dioxygenase Induction in Human Peripheral Blood Monocytes and Peritoneal Macrophages....Pages 547-553
Quinolinic Acid Concentrations are Increased in Cerebrospinal Fluid of Rhesus Macaques (Macaca Mulatta) Naturally Infected with Simian Retrovirus Type....Pages 555-558
Increased L-Tryptophan, 5-Hydroxyindoleacetic Acid, 3-Hydroxykynurenine and Quinolinic Acid Concentrations in Cerebral Cortex Following Systemic Endotoxin Administration....Pages 559-562
Non-Competitive Inhibition of 3-Hydroxyanthranilate-3, 4-Dioxygenase by 4-Chloro-3-Hydroxyanthranilic Acid in Whole Brain of Rat....Pages 563-565
Kynurenine-Pyruvate Aminotransferase in Rat Kidney and Brain....Pages 567-572
Enzymatic Synthesis of Papiliochrome II....Pages 573-577
4-Halo-3-Hydroxyanthranilates are Potent Inhibitors of 3-Hydroxyanthranilate Oxygenase in the Rat Brain in Vitro and in Vivo....Pages 579-582
On the Disposition of De Novo Synthesized Quinolinic Acid in Rat Brain Tissue....Pages 583-586
Brain-Specific Control of Kynurenic Acid Production by Depolarizing Agents....Pages 587-590
Effects of 5-Hydroxytryptophan on Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects....Pages 591-593
The Involvement of Bulbospinal Serotonergic Neurons in the Effect of 5-Hydroxytryptophan on Alpha and Gamma Motoneurons....Pages 595-598
Quinolinic Acid-Induced Decreases in Acetylcholine Release in the Rat Nucleus Basalis Magnocellularis....Pages 599-602
The Role of Transaminations in the Pharmacological Effects of Indole-3-Pyruvic Acid....Pages 603-605
Endocrine Response of Prolactin, Cortisol, and Growth Hormone to Low Dose Intravenous L-Tryptophan in Healthy Subjects During Day and Night....Pages 607-609
Specific Binding of L-Tryptophan to Serum Albumin and its Function in Vivo....Pages 611-614
Effects of L-Tryptophan on the Brainstem Indole and Catecholamine Metabolites in Spontaneously Hypertensive Rats....Pages 615-617
Effects of Tryptophan on the Development of Deoxycorticosterone Acetate (DOCA)-Induced Hypertension in Rats....Pages 619-623
Front Matter....Pages 445-445
Cytotoxicity of 3-Hydroxykynurenine: Implications for CNS Damage in Neonatal Vitamin B-6 Deficiency....Pages 625-629
Pellagra, Mycotoxins and Tryptophan-Niacin Metabolism....Pages 631-636
Levels of Non-Proteic Tryptophan in Milk and Soybean Formulas....Pages 637-640
Characterization of L-Tryptophan Transport into Liver in Suckling Rats....Pages 641-644
Efficiency of Exogenous Quinolinic Acid, A Metabolite of Tryptophan, as a Niacin Precursor in Rats....Pages 645-647
Why does a Difference in Growth Rate between Rats of the Wistar and Sprague Dawley Strains Occur when a Niacin-Free and Tryptophan-Limiting Diet is Fed?....Pages 649-651
Plasma Free 5HT and Platelet 5HT in Depression: Case-Control Studies and the Effect of Antidepressant Therapy....Pages 653-658
Kynurenine and Mesangial-Proliferative Glomerulonephritis....Pages 659-662
Impairment of Kynurenine Metabolism in Cardiovascular Disease....Pages 663-667
Tryptophan and its Metabolites in a Family with Hartnup Disease....Pages 669-674
Effect of Huntington’s and Alzheimer’s Diseases on the Transport of Nicotinic Acid or Nicotinamide Across the Human Blood-Brain Barrier....Pages 675-678
Effects of Profound Insulin-Induced Hypoglycemia on Quinolinic Acid in Hippocampus and Plasma....Pages 679-682
Brain and Cerebrospinal Fluid Quinolinic Acid Concentrations in Patients with Intractable Complex Partial Seizures....Pages 683-686
Cerebrospinal Fluid Quinolinic Acid Concentrations are Increased in Acquired Immune Deficiency Syndrome....Pages 687-690
Production of Quinolinic Acid and Kynurenic Acid by Human Glioma....Pages 691-695
Back Matter....Pages 697-715