Kinins IV: Part A Proceedings of the Fourth International Kinin Congress, held October 21–25, 1984, in Savannah, Georgia

Front Matter....Pages i-xix
The Varied Localization and Functional Significance of Kallikrein-Like Enzymes in Salivary Glands, Pancreas, Colon, Sex Glands and Spermatozoa, Including Evidence for the Presence of Nerve Growth Factor (NGF) in Bull Sperm Acrosome....Pages 1-10
Kininogenase from Rat Vascular Tissue....Pages 11-17
Intracellular and Intercellular Distributions of Acid Kininogenases in Spleen....Pages 19-26
Localization of Kallikreins in the Human Parotid Gland and in the Human Kidney: A Comparative Study of Immunohistochemistry and Enzyme Histochemistry....Pages 27-34
Studies on Carbohydrate Structure and Immunological Properties of Human Urinary Kallikreins....Pages 35-40
Initial Observations of a Kallikrein-Like Enzyme Associated with the Plasma Membranes of Rat Adipocytes....Pages 41-46
Bile Acids and the Intestinal Kallikrein-Kinin System....Pages 47-53
T-Kinin and T-Kininogen — An Historical Overview....Pages 55-59
Increased Plasma Level of T-Kininogen in Rats Treated with Freund’s Adjuvant....Pages 61-68
Isolation and Properties of Two Rat Plasma T-Kininogens....Pages 69-75
Characterization of Kininogen Deficiency of Brown Norway Rat Mutant Katholiek Strain....Pages 77-84
Amino Acid Sequence of the Light Chain of Human High Molecular Mass Kininogen....Pages 85-89
Amino Acid Sequence of the Light Chain of Human Low Molecular Mass Kininogen....Pages 91-95
Limited Proteolysis of HMW Kininogen by Plasma Kallikrein in Man- Evidence for a Processing Mechanism Different from the Bovine System....Pages 97-103
Interaction of Human Low Molecular Weight Kininogen with Human Mast Cell Tryptase....Pages 105-111
Independent Consumption of High and Low Molecular Weight Kininogens in Vivo....Pages 113-118
Urinary Kininogen: A Possible Regulator of Kinin Formation in Normal Individuals and Subjects with Essential Hypertension, End-Stage Renal and Liver Disease....Pages 119-125
Monoclonal Antibodies to Rat Plasma Kininogen....Pages 127-135
Hydrolysis of Rat High Molecular Weight Kininogen by Purified Rat Urinary Kallikrein: Identification of Bradykinin as the Kinin Formed....Pages 137-145
Reduced or Unchanged Cofactor Function of Human High Molecular Weight Kininogen Induced by Human Plasma Kallikrein....Pages 147-153
Studies on the Antigenic Determinants of Human Low Molecular Weight Kininogen....Pages 155-160
Kininogen by the SRI Method in Human Serum During an Acute Phase Inflammatory Reaction....Pages 161-166
Kininogen as a Pregnancy-Associated Plasma Protein....Pages 167-172
Hemodynamics of the Isolated Perfused Rat Kidney in the Absence and Presence of Kallikrein Substrate....Pages 173-180
Active Kallikrein, Preprokallikrein, and Kallikrein-Inhibitor Complex....Pages 181-187
Characterization of Rat Kallikrein-Like Multigene Family and its Expression in the Submandibular Gland....Pages 189-194
Processing of Apolipoprotein B-100 of Human Plasma Low Density Lipoproteins by Tissue and Plasma Kallikreins....Pages 195-202
Transporting Epithelia as Targets for Kinin Effects....Pages 203-210
Purification and Partial Characterization of Cat Colon and Submandibular Gland Kallikreins....Pages 211-218
Purification and Partial Characterization of Cat Pancreatic and Urinary Kallikreins — Comparison with Other Cat Tissue Kallikreins and Related Proteases....Pages 219-228
The Liver is the Main Organ to Clear Plasma and Tissue Kallikreins from Rat Plasma, In Vivo ....Pages 229-233
Receptor-Mediated Clearance of Tissue Kallireins by Rat Liver....Pages 235-239
Tissue Kallikreins and Related Enzymes: Characterization by Model Oligopeptides....Pages 241-246
Release of Kallikrein and Tonin from the Rat Submandibular Gland....Pages 247-254
Effect of Sodium Restriction and Corticosteroids on Glandular Kallikrein in Plasma and in the Submandibular Gland....Pages 255-263
Kallikrein and Kinins Independently Stimulate Renin Release from Isolated Rat Glomeruli....Pages 265-272
Regulation of Parotid Kallikrein Secretion-Role of the Alpha 2 - and Beta-Adrenergic System....Pages 273-277
Effect of Furosemide on the Rat Submandibular Gland Kallikrein Secretion....Pages 279-282
Individual Reaction Steps in the Release of Kallidin from Kininogen by Tissue Kallikrein....Pages 283-289
The Tissue Kallikrein-Kinin System in Human Seminal Plasma — Biochemical and Functional Aspects....Pages 291-297
New Synthetic Substrate for Kallikrein and its Application....Pages 299-308
Plasma Half-Life and Organ Uptake Ratio of Radiolabeled Glandular Kallikrein in Control and Nephrectomized Rats....Pages 309-313
Hormonal Regulation of Glandular Kallikrein Activity and its Inhibitor in Human Plasma....Pages 315-321
A Comparative Study of Prokallikreins and Kallikreins from Rat Pancreatic Tissue and Juice....Pages 323-327
An Inactive Form of Kallikrein in Human Urine....Pages 329-337
Purification of Inactive Kallikrein from Rat Urine....Pages 339-345
Release of Tissue Kallikrein from the Isolated Perfused Kidney....Pages 347-354
Analytical Study of Kallikrein and Kallikrein-Like Esterase Activity in Subfractions from Rat Kidney Cortex Microsomes and Isolated Subcellular Membranes....Pages 355-359
Endogenous Kallikrein Inhibitor in Rat Kidney Cortex-Effect of Glucocorticoid Administration....Pages 361-365
Metabolism of Bradykinin in Isolated Perfused Rat Kidney Measurement of Kininase Activity in Perfusate and Urine....Pages 367-373
Functional Significance of the Subunits of Carboxypeptidase N (Kininase I)....Pages 375-380
Kininase One-An′ -A-Half: The Newest Member of the Kininase Family....Pages 381-388
Partial Characterization of a Liver Serine-Peptidase from Different Species which Inactivates Bradykinin....Pages 389-396
Vascular, Post Proline Cleaving Enzyme: Metabolism of Vasoactive Peptides....Pages 397-404
Synthetic Inhibitors of Carboxypeptidase N....Pages 405-410
Carboxyalkyl Peptide Inhibitors of Kininase II: Chiral Synthesis....Pages 411-417
Slow Tight Binding Inhibitors of Angiotensin Converting Enzyme....Pages 419-425
Radiolabelled Substrates for Angiotensin Converting Enzyme....Pages 427-433
Aggregate Anaphylaxis and Carboxypeptidase N....Pages 435-443
Michaelis-Menten Kinetics of Pulmonary Endothelial Angiotensin Converting Enzyme in the Conscious Rabbit....Pages 445-451
In Vivo Determinations of Ki Values for Angiotensin Converting Enzyme Inhibitors....Pages 453-459
Rat Testicular Angiotensin I Converting Enzyme: Purification and Comparison with Rat Pulmonary Enzyme....Pages 461-467
Kininase II of Human Seminal Fluid: Kinetics and Inhibition....Pages 469-475
Investigations on the Functional Role of Angiotensin Converting Enzyme (ACE) in Human Seminal Plasma....Pages 477-485
Biological Regulation of Testicular Angiotensin I-Converting Enzyme....Pages 487-494
Role of Kininase II (ACE; E.C.3.4.15.1) in the Regulation of Renin Secretion....Pages 495-501
The Effect of Alphanapthylthiourea (ANTU)-Induced Acute Injury on Lung Binding of Antibody to Angiotensin Converting Enzyme (ACE)....Pages 503-512
Isolation and Sequencing of an Active-Site Peptide from Angiotensin I-Converting Enzyme....Pages 513-521
Value of Determination of Kininase II in Bronchoalveolar Lavage Fluid....Pages 523-528
Evidence for a Potent Angiotensin I Degrading Enzyme Different from Angiotensin I Converting Enzyme in Rat Vascular Tissues....Pages 529-536
Bradykinin Competitive Antagonists for Classical Kinin Systems....Pages 537-542
Smooth Muscle Selectivity in Bradykinin Analogs with Multiple D-Amino Acid Substitutions....Pages 543-547
Kinins, Receptors, Antagonists....Pages 549-558
Effects of Kinins on the Isolated Perfused Rat Kidney and Evidence for the Presence of Renal B 1 Receptors....Pages 559-562
 3 H-Bradykinin Binding Site Localization in Guinea Pig Urinary System....Pages 563-570
Action and Metabolism of Des(Arg)kinins in Mesenteric Arteries....Pages 571-575
Activation by Bradykinin and Vasoactive Intestinal Peptide of Adenylate Cyclase from Immunologically Sensitized Lung Membranes....Pages 577-583
Back Matter....Pages 585-590