Kinetic Data Analysis: Design and Analysis of Enzyme and Pharmacokinetic Experiments

Front Matter....Pages i-ix
An Introduction to Nonlinear Least Squares....Pages 1-24
Statistical Properties of Kinetic Estimates....Pages 25-37
On Parameter Redundancy in Curve Fitting of Kinetic Data....Pages 39-50
Tangential and Curvilinear Coordinates in Nonlinear Regression....Pages 51-57
Use of Multiple Linear Regression in the Analysis and Interpretation of Biokinetic Data....Pages 59-71
Multivariate Statistical Methods in Pharmacokinetics....Pages 73-87
Tests for the Behaviour of Experimental Errors....Pages 89-103
Robust Estimation in Enzyme Kinetics....Pages 105-119
Robust Alternatives to Least-Squares Curve-Fitting....Pages 121-135
Design of Experiments for Estimating Enzyme and Pharmacokinetic Parameters....Pages 137-167
Experimental Designs for the Distribution-Free Analysis of Enzyme Kinetic Data....Pages 169-179
A Priori Identifiability Analysis in Pharmacokinetic Experiment Design....Pages 181-208
A Frequency Response Method for Pharmacokinetic Model Identification....Pages 209-233
Design and Analysis of Kinetic Experiments for Discrimination between Rival Models....Pages 235-270
Estimation of Pooled Pharmacokinetic Parameters Describing Populations....Pages 271-284
Analysis of Sets of Estimates from Pharmacokinetic Studies....Pages 285-297
Some Current Problems in the Interpretation of Enzyme Kinetic Data....Pages 299-308
Errors Associated with the Determination of the Initial Velocities of Enzyme-Catalyzed Reactions....Pages 309-315
Progress Curves in Enzyme Kinetics: Design and Analysis of Experiments....Pages 317-339
Applications of Progress Curves in Enzyme Kinetics....Pages 341-352
Data Analysis from Michaelis-Menten Kinetics: Ins and Outs....Pages 353-373
A Generalized Numerical Deconvolution Procedure for Computing Absolute Bioavailability — Time Profiles....Pages 375-389
Influence of Variability in Plasma Concentration on Dose Prediction Assuming Michaelis-Menten Kinetics....Pages 391-414
Back Matter....Pages 415-427