Kawasaki Disease: Current Understanding of the Mechanism and Evidence-Based Treatment

Front Matter....Pages i-xix
Front Matter....Pages 1-1
The History of Kawasaki Disease: A Personal Perspective....Pages 3-9
Histopathology of Coronary Arteritis in Acute Kawasaki Disease and Murine Systemic Vasculitis Induced by Candida Albicans Cell Wall Polysaccharide....Pages 11-16
Histopathological Characteristics of Noncardiac Organs in Kawasaki Disease....Pages 17-22
Identification of Novel Kawasaki Disease Susceptibility Genes by Genome-Wide Association Studies....Pages 23-29
Immunological Abnormalities and Use of Biomarkers and Cytokines to Predict the Severity of Kawasaki Disease....Pages 31-37
Pathophysiology of Kawasaki Disease....Pages 39-44
Update on Pathogenesis: Lessons Learned from Animal Models of Disease....Pages 45-51
The Climate–KD Link....Pages 53-57
Kawasaki Disease Shock Syndrome....Pages 59-63
Future Directions in Kawasaki Disease Research....Pages 65-69
Front Matter....Pages 71-71
Epidemiologic Perspectives....Pages 73-77
Update on Nationwide Surveys and Epidemiologic Characteristics of Kawasaki Disease in Japan....Pages 79-84
Kawasaki Disease Epidemiology in Europe....Pages 85-89
Recent Topics in the Epidemiology of Kawasaki Disease....Pages 91-94
Front Matter....Pages 95-95
Overview of Medical Treatment....Pages 97-101
Overview of the New Japanese Guideline2012 for the Medical Treatment of Acute Stage of Kawasaki Disease....Pages 103-167
Tumor Necrosis Factor-α Blockade for Treatment of Acute Kawasaki Disease....Pages 169-173
Methylprednisolone Pulse Therapy for Nonresponders to Immunoglobulin Therapy....Pages 175-179
Prednisolone....Pages 181-185
Cyclosporin A for IVIG Nonresponders....Pages 187-194
Front Matter....Pages 95-95
Other Challenging Therapies....Pages 195-198
Antiplatelet and Antithrombotic Therapy for Giant Coronary Aneurysm....Pages 199-205
Characteristics of Sudden Cardiac Death Late After Acute Kawasaki Disease....Pages 207-213
Kawasaki Disease Diagnosis and Complication Rates in the United States and Japan....Pages 215-222
Mechanism of Action of Immunoglobulin: Sialylated IgG....Pages 223-230
Treatment Options for Refractory Kawasaki Disease: Alternative Treatments for Infliximab Nonresponders....Pages 231-237
Ulinastatin....Pages 239-244
Front Matter....Pages 245-245
Diagnosis and Management of Cardiovascular Risk Factors....Pages 247-254
Diagnosis and Characteristics of Typical and Incomplete Kawasaki Disease....Pages 255-269
Scoring Systems to Predict Coronary Artery Lesions and Nonresponse to Initial Intravenous Immunoglobulin Therapy....Pages 271-277
Use of Magnetic Resonance Angiography for Assessment of Coronary Artery Lesions Caused by Kawasaki Disease....Pages 279-284
CT Coronary and Myocardial Images in Patients with Coronary Artery Lesions....Pages 285-295
Long-Term Follow-Up and Education Regarding Daily Life Activities, School Life, and Guidelines After Acute KD....Pages 297-301
Assessment of Cardiac Ischemia During Acute and Long-Term Follow-Up and Rheologic Assessment of Coronary Artery Lesions After Kawasaki Disease....Pages 303-310
Promising Biomarkers in Acute Kawasaki Disease and Acute Coronary Ischemia....Pages 311-319
Coronary Artery Diameter Z Score Calculator....Pages 321-333
Evidence of Endothelial Damage in Acute KD....Pages 335-340
Oxidative Stress in Kawasaki Disease....Pages 341-352
Front Matter....Pages 353-353
Antiplatelet and Anticoagulant Therapies for Kawasaki Disease: Theory and Practice....Pages 355-372
Guideline for Catheter Intervention in Coronary Artery Lesion in Kawasaki Disease....Pages 373-382
Front Matter....Pages 353-353
Long-Term Clinical Follow-Up After Rotational Atherectomy for Coronary Arterial Stenosis in Kawasaki Disease....Pages 383-387
Long-Term Outcomes of Pediatric Coronary Artery Bypass Grafting and Down-Sizing Operation for Giant Coronary Aneurysms....Pages 389-406
Long-Term Graft Patency and Surgical Outcomes of Coronary Artery Bypass Surgery in Children with Kawasaki Disease....Pages 407-417
Front Matter....Pages 419-419
Functional and Structural Alterations of Coronary Arteries Late After Kawasaki Disease and the Risk of Acute Coronary Syndrome in Adults....Pages 421-425
Psychosocial Effects of Kawasaki Disease and Transition to Adult Care....Pages 427-437
Kawasaki Disease: Road Map for the Future....Pages 439-443
Back Matter....Pages 445-552