Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate

 Content: Juvenile Hormones and Juvenoids: A Historical Survey James Devillers  Future Perspectives for Research on the Biosynthesis of Juvenile Hormones and Related Sesquiterpenoids in Arthropod Endocrinology and Ecotoxicology Jerome H.L. Hui, William G. Bendena, and Stephen S. Tobe  Morph-Specific JH Titer Regulation in Wing-Polymorphic Gryllus Crickets: Proximate Mechanisms Underlying Adaptive Genetic Modification of JH Regulation Anthony J. Zera  Soldier-Specific Organ Developments Induced by a Juvenile Hormone Analog in a Nasute Termite Kouhei Toga and Kiyoto Maekawa  Roles of Juvenile Hormone Analog Methoprene in Gene Transcription Xiao-Fan Zhao  Modeling Resistance to Juvenile Hormone Analogs: Linking Evolution, Ecology, and Management David W. Crowder, Peter C. Ellsworth, Steven E. Naranjo, Bruce E. Tabashnik, and Yves Carriere  Population Dynamics Models for Assessing the Endocrine Disruption Potential of Juvenile Hormone Analogues on Nontarget Species James Devillers and Hugo Devillers  SAR and QSAR Modeling of Juvenile Hormone Mimics James Devillers  Using CoMFA and CoMSIA as Tools in a 3D QSAR Analysis of Juvenile Hormone Agonist Action in Drosophila Robert Farkas and Maja Polakovicova Predicting Highly Potent Juvenile Hormone Esterase Inhibitors from 2D QSAR Modeling James Devillers, Annick Doucet-Panaye, and Jean-Pierre Doucet  Receptor-Guided Structure-Activity Modeling of Inhibitors of Juvenile Hormone Epoxide Hydrolases Julio Caballero  Structural Studies of Juvenile Hormone-Binding Proteins Agnieszka J. Pietrzyk, Mariusz Jaskolski, and Grzegorz Bujacz  In Silico Stereoelectronic Profile and Pharmacophore Similarity Analysis of Juvenile Hormone, Juvenile Hormone Mimics (IGRs), and Insect Repellents May Aid Discovery and Design of Novel Arthropod Repellents Apurba K. Bhattacharjee  Use of Multicriteria Analysis for Selecting Candidate Insecticides for Vector Control James Devillers, Laurent Lagadic, Ohri Yamada, Frederic Darriet, Robert Delorme, Xavier Deparis, Jean-Philippe Jaeg, Christophe Lagneau, Bruno Lapied, Francoise Quiniou, and Andre Yebakima
 Abstract:             Juvenile hormones (JHs) are a group of structurally related sesquiterpenes secreted by the insect corpora allata. They affect most insect life-cycle stages and physiological functions, including embryogenesis, larval and adult development, metamorphosis, reproduction, metabolism, diapause, polyethism, and migration. Juvenoids such as methoprene, hydroprene, kinoprene, pyriproxyfen, and fenoxycarb are man-made chemicals that mimic the structure and/or activity of JHs, selectively targeting and disrupting the endocrine system of insects. They are particularly suited as larvicides for the control