Janeway's Immunobiology (9780393884678)

Cover
Title Page
Publisher’s Notice
Copyright
Preface
What’s New in the Tenth Edition
Resources for Instructors and Students
Acknowledgments
About the Authors
Contents in Brief
Detailed Contents
Chapter 1: Basic Concepts in Immunology
The origins of vertebrate immune cells.
Principles of innate immunity.
Principles of adaptive immunity.
The effector mechanisms of immunity.
References
Chapter 2: Innate Immunity: The First Lines of Defense
Anatomic barriers and initial chemical defenses.
The complement system and innate immunity.
End of Chapter Questions and References
Chapter 3: Cellular Mechanisms of Innate Immunity
Pathogen recognition by cells of the innate immune system.
Consequences of innate immune activation.
End of Chapter Questions and References
Chapter 4: Antigen Recognition by B-cell and T-cell Receptors
The structure of a typical antibody molecule.
Structural variation in immunoglobulin constant regions.
The interaction of the antibody molecule with specific antigen.
Antigen recognition by T cells.
End of Chapter Questions and References
Chapter 5: The Generation of Lymphocyte Antigen Receptors
Primary immunoglobulin gene rearrangements and expression.
T-cell receptor gene rearrangement.
Evolution of the adaptive immune response.
End of Chapter Questions and References
Chapter 6: Antigen Presentation to T Lymphocytes
The generation of αβ T-cell receptor ligands.
The major histocompatibility complex and its function.
Recognition of nonpeptide ligands by unconventional T-cell subsets.
End of Chapter Questions and References
Chapter 7: Lymphocyte Receptor Signaling
General principles of signal transduction and propagation.
Antigen receptor signaling and lymphocyte activation.
Co-stimulatory and inhibitory receptors modulate antigen receptor signaling in T and B lymphocytes.
End of Chapter Questions and References
Chapter 8: The Development of B and T Lymphocytes
Development of B lymphocytes.
Development of T lymphocytes.
Positive and negative selection of T cells.
End of Chapter Questions and References
Chapter 9: T Cell–Mediated Immunity
Development and function of secondary lymphoid organs–sites for the initiation of adaptive immune responses.
Naive T-cell activation, clonal expansion, and differentiation into effector and memory T cells.
General properties of effector T cells and their cytokines.
T cell–mediated cytotoxicity.
End of Chapter Questions and References
Chapter 10: The Humoral Immune Response
B-cell activation by antigen and helper T cells.
The distributions and functions of immunoglobulin classes.
The destruction of antibody-coated pathogens via Fc receptors.
End of Chapter Questions and References
Chapter 11: Integrated Dynamics of Innate and Adaptive Immunity
Integration of innate and adaptive immunity in response to specific types of pathogens.
Effector CD4 T cells augment the effector functions of innate immune cells.
Immunological memory.
End of Chapter Questions and References
Chapter 12: The Barrier Immune System
Organization of the mucosal immune system.
Innate immune defenses of the intestinal immune system.
The role of adaptive immunity in regulating the intestinal mucosal immune system at homeostasis.
The intestinal immune response in host defense and immune-mediated disease.
Immunity at other barrier tissues.
End of Chapter Questions and References
Chapter 13: Failures of Host Defense Mechanisms
Immunodeficiency diseases.
Evasion and subversion of immune defenses.
Acquired immune deficiency syndrome.
End of Chapter Questions and References
Chapter 14: Allergic Diseases and Hypersensitivity Reactions
IgE and IgE-mediated allergic diseases.
Effector mechanisms in IgE-mediated allergic reactions.
Non-IgE-mediated allergic diseases.
End of Chapter Questions and References
Chapter 15: Autoimmunity and Transplantation
The making and breaking of self-tolerance.
Autoimmune diseases and pathogenic mechanisms.
The genetic and environmental basis of autoimmunity.
Responses to alloantigens and transplant rejection.
End of Chapter Questions and References
Chapter 16: Manipulation of the Immune Response
Fighting infectious diseases with vaccination.
Using the immune response to attack tumors.
Treatment of unwanted immune responses.
End of Chapter Questions and References
Appendix I: The Immunologist’s Toolbox
Appendix II: CD Antigens
Appendix III: Cytokines and Their Receptors
Appendix IV: Chemokines and Their Receptors
Glossary
Credits
Index
Movies and Animations
Endpaper