IUPHAR 9th International Congress of Pharmacology London 1984: Proceedings Volume 3

Front Matter....Pages i-x
Front Matter....Pages 1-1
Vascular and platelet effects of prostacyclin and prostaglandin D2 in man....Pages 3-6
Prostacyclin and cerebral circulation....Pages 7-12
Effect of prostanoids on the coronary circulation....Pages 13-19
Effects of aspirin and dazoxiben upon the peripheral circulation in man....Pages 21-28
Controlled trials on the effects of prostacyclin in vascular disease....Pages 29-35
Front Matter....Pages 37-37
Leukotriene A4: mechanism of formation and enzymatic hydrolysis....Pages 39-42
Formation and mechanism of action of leukotrienes: enzymatic hydration of leukotriene A4 by human blood cells....Pages 43-48
Pharmacological studies on the release and effects of leukotrienes in human and guinea pig lung tissue....Pages 49-53
Substrate and regulatory functions of eicosapentaenoic and docosahexaenoic acids for the 5-lipoxygenase pathway....Pages 55-61
Actions of leukotrienes in the circulation....Pages 63-67
Leukotriene B4: a mediator of leukocyte function....Pages 69-71
Front Matter....Pages 73-73
Biological and clinical aspects of oestrogen receptor measurements in rapidly progressing breast cancer....Pages 75-79
Unexpected oestrogenic activity in a derivative of antioestrogenic triphenylethylenes....Pages 81-84
The regulation of the biological function of steroid-receptors in chickens and humans....Pages 85-91
Phosphorylation of the glucocorticoid receptor....Pages 93-99
Front Matter....Pages 101-101
Neurochemical and molecular studies of antidepressant effects in the modelled depression in animals....Pages 103-108
Regulation of 5-hydroxytryptamine (5HT) uptake: endocoid modulators and the action of imipramine....Pages 109-116
β-Adrenoceptor agonists, ECT and other antidepressants: effects on serotonin biochemistry and function....Pages 117-124
Central β-adrenoceptor regulation and adaptation under physiological and pathophysiological conditions....Pages 125-130
α2-Adrenoceptors and antidepressant treatments....Pages 131-136
Front Matter....Pages 101-101
Mechanism of action of antidepressant drugs given repeatedly: changes in the responses mediated by noradrenaline (α1) and dopamine receptors....Pages 137-143
Front Matter....Pages 145-145
The acquisition of methotrexate resistance by gene amplification....Pages 147-150
Front Matter....Pages 151-151
Electrophysiology of GABA receptors in the vertebrate central nervous system....Pages 153-158
Bicuculline-insensitive GABAB receptors....Pages 159-170
Purification and properties of the GABA/benzodiazepine/barbiturate receptor protein from rat brain....Pages 171-177
GABA receptors and related binding sites....Pages 179-183
GABA Receptors: clinical implications....Pages 185-192
GABA Receptors — Co-Chairman’s concluding remarks....Pages 193-194
Front Matter....Pages 195-195
Characterization of the multiplicity of drug-metabolizing enzymes: observations on cytochrome P-450 diversity....Pages 197-202
Multiplicity and functional diversity of rat hepatic microsomal cytochrome P450 isozymes....Pages 203-209
Multiplicity of cytochrome P-450 and its gene structure....Pages 211-217
Tissue and cellular differences in the expression of cytochrome P-450 isozymes....Pages 219-224
Species and tissue differences in the occurrence of isoenzymes of glutathione transferase....Pages 225-230
Multiple forms of epoxide hydrolase....Pages 231-237
Front Matter....Pages 239-239
Therapeutic infarct size reduction....Pages 241-245
Is drug induced reduction of the infarct size essential for protection against sudden coronary death?....Pages 247-250
Myocardial salvage by pharmacological interventions....Pages 251-256
Evidence for myocardial salvage in human clinical ischaemia....Pages 257-268
Front Matter....Pages 269-269
Approaches to the rational design of peptide analogues for use in therapy....Pages 271-275
Metabolism of enkephalins and its inhibition....Pages 277-282
Front Matter....Pages 269-269
Substance P antagonists as a new type of drug....Pages 283-285
ACTH-like neuropeptides as potential psychoactive and neuroactive drugs....Pages 287-291
Front Matter....Pages 293-293
Interleukin 2 and other immunoregulatory T cell lymphokines: biological significance....Pages 295-300
Interleukin-1: An Overview....Pages 301-306
Different immunosuppressive activity of equimolar doses of prednisolone prodrugs....Pages 307-309
Lymphokines that mediate inflammation....Pages 311-321
The role of lymphokines and cytokines in tumour development and surveillance....Pages 323-337
Front Matter....Pages 339-339
Clinical aspects of gastric protection....Pages 341-344
Biosynthesis of endogenous arachidonate products involved in gastric damage and protection....Pages 345-354
Mechanisms of cytoprotection....Pages 355-359
Morphological and trophic actions of prostanoids on the gastrointestinal mucosa....Pages 361-365
Cellular aspects of mucosal damage and protection....Pages 367-371
The mucus and bicarbonate barrier in gastroduodenal defence....Pages 373-381
Back Matter....Pages 383-390