IUPHAR 9th International Congress of Pharmacology: Proceedings Volume 2

Front Matter....Pages i-x
Front Matter....Pages 1-1
From foxglove to the heart: classification and mode of action of inotropic agents....Pages 3-12
The use of isolated mammalian cardiac myocytes for the study of inotropic mechanisms....Pages 13-19
Age-related changes in cardiac responsiveness to positive inotropic agents....Pages 21-27
Front Matter....Pages 29-29
Phospholipase A2 inhibitors Introduction: an overview....Pages 31-34
The active site of phospholipase A2....Pages 35-37
Lipomodulin, a naturally occurring phospholipase A2 inhibitory protein....Pages 39-41
Renocortin: a phospholipase A2 inhibitory protein induced by anti-inflammatory steroids: pharmacological and biological properties, development of monoclonal antibodies....Pages 43-46
Glucocorticoid-induced phospholipase inhibitory proteins....Pages 47-50
Front Matter....Pages 51-51
The role of adrenaline in essential hypertension in man....Pages 53-56
Glutathione and tissue toxicity....Pages 57-66
Front Matter....Pages 67-67
Symposium 13: Analysis of drug mechanisms by single ion channel recording — An Overview....Pages 69-72
Front Matter....Pages 73-73
Receptor mapping by means of interaction energy calculations....Pages 75-79
N.m.r. studies of drug-receptor interactions as an aid to drug design....Pages 81-87
Physicochemical properties in structure-activity analysis....Pages 89-92
Conformational analysis and neuroleptic pharmacophore identification....Pages 93-98
Front Matter....Pages 99-99
Discovery and clinical evaluation of novel antihypertensive drugs....Pages 101-104
Angiotensin converting enzyme inhibitors in the treatment of hypertension....Pages 105-110
Novel antihypertensive drugs: β-adrenoceptor antagonists and drugs with additional properties....Pages 111-120
α-Adrenoceptor agonists and antagonists in the treatment of hypertension....Pages 121-128
Novel antihypertensive drugs — thoughts for the future....Pages 129-132
Front Matter....Pages 133-133
New perspectives on the molecular mechanism of action of peptide secretagogues....Pages 135-139
Mechanisms involved in the regulation of calcium metabolism by secretagogues in the exocrine pancreas....Pages 141-146
A comparison of the phosphorylation of Mr = 33k, 21k, and 25k membrane-bound proteins in the rat pancreas, submitted to various secretagogues....Pages 147-156
The role of inositol phospholipid turnover in the actions of peptide secretagogues....Pages 157-162
New perspectives in the identification, distribution and processing of peptide hormones and neurotransmitters: the gastrins....Pages 163-168
Co-existence of peptides and classical neurotransmitters in autonomic regulation of blood flow and exocrine secretion....Pages 169-175
Front Matter....Pages 177-177
Enzymological and pharmacological aspects of monoamine oxidase....Pages 179-185
Endogenous substrates and inhibitors of monoamine oxidase....Pages 187-192
Connections between monoamine oxidase, temperament and disease....Pages 193-202
The role of monoamine oxidase A in the metabolism and function of noradrenaline and serotonin....Pages 203-209
In vitro pharmacology of reversible inhibitors of monoamine oxidase....Pages 211-218
Some pharmacological and clinical aspects of reversible MAO inhibitors....Pages 219-230
Front Matter....Pages 231-231
Free radical metabolites of l-cysteine and glutathione oxidation....Pages 233-241
Mechanistical studies and prevention of free radical cell injury....Pages 243-250
Free radical intermediates and liver cell necrosis....Pages 251-257
Models for bleomycin antitumour antibiotics: haeminacridines which bind to DNA, cause oxygen-dependent strand scission, and exhibit anticancer properties....Pages 259-264
Front Matter....Pages 265-269
Neuropeptide precursors and acetylcholine receptor: molecular structures and gene expression....Pages 271-271
Cancer chemotherapy: examples of current progress and future perspectives....Pages 273-288
Receptors for thromboxane and prostaglandins....Pages 289-292
Front Matter....Pages 293-301
Activation of calmodulin by metal cations and occupancy of its metal-binding sites....Pages 271-271
Front Matter....Pages 303-319
Chemical structure and pharmacological activities of Ca2+ channel antagonists....Pages 321-321
Molecular pharmacology of the calcium channel....Pages 323-328
Vascular smooth muscle and drugs affecting calcium channels....Pages 329-335
Pharmacology of calcium currents in mammalian central neurones....Pages 337-342
Site of action of Lambert-Eaton myasthenic syndrome antibodies at mouse nerve terminals....Pages 343-348
Front Matter....Pages 349-351
Intermediary metabolism and its regulation in parasitic worms in a strategy for chemotherapy....Pages 353-353
Relationships of niridazole metabolism to antiparasitic efficacy and host toxicity....Pages 355-361
The filarial worm as a target for chemotherapy: pharmacological and biological factors influencing drug efficacy....Pages 363-367
Studies of conditions and agents that stimulate and inhibit the production of cachectin by macrophages....Pages 369-375
New approach in design of selectively toxic antimalarials....Pages 377-384
Mechanism of action of antitrichomonal drugs....Pages 385-389
New strategies in antiparasitic chemotherapy: Concluding remarks....Pages 391-397
Back Matter....Pages 399-404
....Pages 405-412