IUPHAR 9th International Congress of Pharmacology London 1984: Proceedings

Front Matter....Pages i-6
Front Matter....Pages 7-7
Localization of functional activity in the central nervous system by metabolic probes....Pages 9-29
Pharmacological approaches to neuropeptide function: substance P....Pages 31-41
Neglect of function and obsession with structure in toxicity testing....Pages 43-49
Receptor localisation in asymmetric cells....Pages 51-59
William Withering Commemoration Lecture: Withering’s discovery and his modern scientific legacy....Pages 61-72
Front Matter....Pages 73-73
Introduction: Receptors and receptor-mediated responses....Pages 75-80
Axonal transport of receptors....Pages 81-84
Mechanisms of desensitization of β-adrenergic receptors....Pages 85-90
Front Matter....Pages 91-91
β-Lactam antibiotics with novel nuclei....Pages 93-98
Mechanisms of β-lactamase action....Pages 99-104
Thienamycin, imipenem and new members of the carbapenem class of β-lactam antibiotics....Pages 105-109
Monobactams and other monocyclic β-lactams....Pages 111-114
Exploration of active sites of DD-peptidases....Pages 115-123
Front Matter....Pages 125-125
The relative importance of inositol 1,4,5-trisphosphate, 1,2-diacylglycerol and phosphatidic acid in mediating human platelet activation by thrombin....Pages 127-131
Front Matter....Pages 133-133
Cyclic nucleotides in smooth muscle relaxation....Pages 135-142
Relaxation of vascular smooth muscle by inhibitors of calmodulin and cyclic nucleotide dependent protein kinase....Pages 143-147
Comparison of endothelium-dependent relaxation by acetylcholine and endothelium-independent relaxation by light in the rabbit aorta....Pages 149-157
Non-adrenergic, non-cholinergic inhibitory mechanisms....Pages 159-164
Mechanisms of coronary vasodilation induced by antianginal agents....Pages 165-171
Activity of single potassium channels recorded from single isolated visceral and vascular smooth muscle cells....Pages 173-177
Front Matter....Pages 179-179
Insulin receptor structure....Pages 181-187
Front Matter....Pages 189-189
Tissue selective toxicity: Introduction....Pages 191-195
Selective activation of chemicals by the kidney: its relevance to toxicity and mutagenicity....Pages 197-202
Selective activation of carcinogens and other toxicants by nasal mucosae....Pages 203-208
Biochemical selectivity in neurotoxicity....Pages 209-215
Front Matter....Pages 217-217
Molecular pharmacology of the sodium channel of mammalian brain....Pages 219-229
Dopaminergic nerves....Pages 231-244
The problems of extrapolating laboratory data to man in teratology....Pages 245-259
Front Matter....Pages 261-261
Inhibitory modulation of adenylate cyclase....Pages 263-269
Chemical modification of nucleotide regulatory proteins catalyzed by bacterial toxins....Pages 271-278
Structural and regulatory properties of nucleotide binding regulatory N proteins of adenylate cyclase and their effects on hormone receptors....Pages 279-286
Guanine nucleotide-binding regulatory proteins: a family of membrane-bound transducers....Pages 287-291
Purification, characterization and reconstitution of the adenylate cyclase-coupled β-adrenergic receptor....Pages 293-297
Front Matter....Pages 299-299
Enzymes as antiviral targets....Pages 301-306
Modes of action of interferon and analogues of 2-5A, a mediator of interferon action....Pages 307-317
Pharmacological considerations of antiviral agents....Pages 319-322
Clinical experience with antivirals....Pages 323-330
Control of epidemic influenza virus: aspects of vaccines and antiviral compounds....Pages 331-339
Prospects for the future in antiviral chemotherapy....Pages 341-345
Front Matter....Pages 347-347
Pain mechanisms....Pages 349-349
Front Matter....Pages 347-347
Ontogenetic and phylogenetic influences on the expression of pain....Pages 351-358
Endorphins and the control of pain: anatomical studies of enkephalin and dynorphin....Pages 359-365
Opioid peptides: endogenous analgesics?....Pages 367-382
Techniques of the management of pain....Pages 383-385
Progress in the pharmacological studies of acupuncture analgesia....Pages 387-394
Back Matter....Pages 395-402