Ischemic Blood Flow in the Brain

Front Matter....Pages I-XX
Front Matter....Pages 1-1
Historical Review of Developments in the Field of Cerebral Blood Flow and Metabolism....Pages 3-10
Front Matter....Pages 11-11
Mechanisms of Mechanochemical Transduction in Vascular Cells....Pages 13-19
Ultra Long Range Forces Between Macroscopic Bodies....Pages 20-24
Role of the Endothelial Surface Coat in Microvessel Blood Flow....Pages 25-32
Blood-Brain Barrier: Role of Brain Endothelial Surface Charge and Glycocalyx....Pages 33-38
The Role of the Endothelial Surface Coat in Microvascular Permeability....Pages 39-46
Front Matter....Pages 47-47
Mechanism of Inhibitory Effect of Hypoxia/Reoxygenation on Gap Junctional Intercellular Communication of Vascular Endothelial Cells in Culture....Pages 49-56
Proteolytic Opening of the Blood-Brain Barrier During Neuroinflammation....Pages 57-63
Endothelial Dysfunction After Brain Ischemia and Reperfusion....Pages 64-69
Local Blood-Brain Barrier Damage,Cerebral Edema,and Cell Injury During Reperfusion After 2 Hours of Focal Cerebral Ischemia....Pages 70-75
Temporal Profile of Ischemic Edema:Comparison of Ultrastructure,Gravimetry, and Evans Blue Permeability....Pages 76-82
Perivascular Cells of Small Cerebral Vessels (FGP, Mato cells) and Their Permeability Under Pathological Conditions....Pages 83-88
Front Matter....Pages 89-89
Effects of lschemia on Expression of Cyclooxygenase and Endothelial Nitric Oxide Synthase in the Cerebral Circulation....Pages 91-97
Role of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in the Mechanisms of Ischemic Brain Injury....Pages 98-107
Dual Pathways of Free Radical Injury in Vascular Endothelial Cells: Loss of Nuclear DNA Integrity and Membrane Asymmetry During Enhanced Cysteine Protease Activity....Pages 108-119
Vascular Endothelial Growth Factor: Protection Against Ischemic Brain Damage with MCA Occlusion in Rats....Pages 120-127
Effect of Induction of Inducible Nitric Oxide Synthase on the Blood-Brain Barrier in the Rat....Pages 128-135
Adenovirus-Mediated Gene Transfer to Cerebral Blood Vessels and Ischemic Brain: Perivascular Approach and Ischemic Threshold....Pages 136-141
Recombinant Nitric Oxide Synthase Gene Transfer: Potential Roles in Gene Therapy of Cerebrovascular Disease....Pages 142-147
Front Matter....Pages 149-149
Microvascular Integrin-Matrix Responses to Focal Cerebral Ischemia Are Rapid and Reflect Neuron Injury....Pages 151-160
Front Matter....Pages 149-149
Glial Cell Line-Derived Neurotrophic Factor: Protection Against Ischemic Brain Injury in Association with Reduced Apoptotic Signals but No rCBF Improvement....Pages 161-167
Postischemic Hyperperfusion Does Not Necessarily Indicate Good Recovery of Brain Tissue. From the Viewpoint of PKA-Mediated Intracellular Signal Transduction....Pages 168-177
Hemorrhage-Induced Brain Ischemia: Modulatory Role of Endogenous Opioids and Antiopioids in the Cerebrovascular Bed....Pages 178-194
Pathophysiological Consequences of White Matter Compared to Gray Matter Ischemia....Pages 195-201
Apoptosis in Cerebral Vasospasm After Subarachnoid Hemorrhage....Pages 202-208
Front Matter....Pages 209-209
Multitracer Pet Studies in Mcao of Cats as a Model for Acute Ischemic Stroke....Pages 211-220
Activation CBF Varied by Perturbation of PaCO 2 and PaO 2 Level: PET Study....Pages 221-225
Comparison of Multitracer PET and Functional MRI in a Pig MCAO Model for Acute Ischemic Stroke....Pages 226-231
Cerebral Blood Flow, Hemoglobin Oxygenation, and Water Diffusion Changes During Stroke: Fingerprinting with Near-Infrared Spectroscopy and MRI....Pages 232-240
Evolution of Capillary Perfusion Deficits in Ischemic Rat Brains....Pages 241-248
In Vivo Investigation of the Cortical Microcirculation Under Ischemia/Reperfusion in Rats Using Dynamic Laser Confocal Fluorescence Microscopy....Pages 249-255
Blood Flow Values in the Ischemic Brain Tissue as Influenced by Factor m with Loss of Tissue Vivacity....Pages 256-261
Front Matter....Pages 263-263
Role of Nitric Oxide in Variations of the Response of Cerebral Blood Flow to Hypotension and Focal Ischemia....Pages 265-281
Heterogeneous Autoregulatory Capacity in the Rat Cerebral Cortex as Observed by a Novel Two-Dimensional Flow Mapping Technique....Pages 282-288
Changes in Cerebrovascular Reactivity After Stimulation and Depletion of Sensory Fibers in Rats....Pages 289-295
Impact of Focal Ischemia/Reperfusion on the Microcirculation in Cerebral Cortex in Rats....Pages 296-303
Erythrocyte Flow in the Cerebral Capillary Network During Ischemia and Hypoxemia: Observations with Intravital Microscopy....Pages 304-312
Brain Microvasculature: Evidence for Interactive Endothelium-Dependent Responses Induced by Endothelin-1 and Nitric Oxide*....Pages 313-318
Acute and Delayed Effects of Transient Global Cerebral Ischemia on Rat Brain Capillary Endothelial Cells in Vivo....Pages 319-325
Heme Oxygenase-Carbon Monoxide System as a Regulator of Microvascular Function....Pages 326-332
Front Matter....Pages 333-333
Evidence for CSD or CSD-Like Phenomena in Human Brain in Relation to Migraine and Stroke....Pages 335-342
Responses to Cortical Spreading Depression During Normoxia and Ischemia: Multiparametric Monitoring Study in Animals and the Human Brain....Pages 343-350
Profiles of Transient Cortical Depolarization and Calcium Ion Influx in Periinfarct Regions of Focal Cerebral Ischemia in Cats....Pages 351-355
Temporal and Spatial Evolution of Cortical Blood Flow in the Penumbra of Venous Infarcts....Pages 356-363
Quantitative Topography of the Hemodynamic-Oxidative Metabolic Interrelation by Multispot Measurement Approach in Rat Ischemia Models....Pages 364-368
Role of Altered Blood Properties in the Propagation of Ischemic Blood Flow: Contribution of Aging and Oxidative Stress....Pages 369-380
Direct Repeated Measurements of PO 2 in the Brain During Ischemia and Reperfusion....Pages 381-389
Front Matter....Pages 391-391
TNFα, Endothelium, and Microcirculation in Stroke Initiation, Progression, and Tolerance....Pages 393-400
Coagulation Triggered by Erythrocyte Membrane and Its Possible Significance in Thrombus Formation....Pages 401-406
Effect of Intraischemic Hypothermia on Intercellular Adhesion Molecule-1 and Migration of Neutrophils....Pages 407-412
Selective Thrombin Inhibitor (Argatroban): Amelioration of Platelet Adhesion to Human Brain Microvascular Endothelial Cells In Vitro: Observation with Video-Enhanced Contrast Microscopy....Pages 413-419
MRI Demonstrates that Tissue-Type Plasminogen Activator Increases Stroke Volume if Cerebral Arteries Are not Successfully Recanalized....Pages 420-427
Front Matter....Pages 429-429
Microvascular Pathology in Familial Multiinfarct Dementia or CADASIL: Implications for Cerebral Blood Flow....Pages 431-442
Neural Activation and Glucose Metabolism in Hemodynamic Ischemia....Pages 443-447
Effects of Hyperthermia and Hypothermia on Ischemic Vascular Damages....Pages 448-454
Back Matter....Pages 455-466