Ir Genes: Past, Present, and Future

Front Matter....Pages i-xxvi
Front Matter....Pages 1-1
Ia Genes, Gene Products, and Determinants....Pages 3-12
Murine T Cell-Specific IA Antigens: Helper T Lymphocytes Express a Unique I-A -Encoded Molecule....Pages 13-17
Definition of New Ia + T Cell Subsets....Pages 19-22
Antibody and T Cell Recognition of Select Ia Determinants Using the I-A Mutant B6.C- H-2 bm12 ....Pages 23-28
Induction of Autoreactive T Cells by Stimulation Across the I-J Subregion....Pages 29-38
Enhancement of Murine T Cell I-J Expression by Limited Proteolysis....Pages 39-43
Isolation and Analysis of Subpopulations of I-A b Molecules with Monoclonal Antibodies....Pages 45-49
Partial Characterization of 8 Anti-I-J and 3 Anti-Ia Monoclonal Reagents....Pages 51-55
Interspecies Cross Reactivity of Monoclonal Anti-I-E Antibodies Specific for Polymorphic Ia Determinants....Pages 57-61
Structural Characterization of I-A b Subsets Using Monoclonal Antibodies....Pages 63-67
Factor-Mediated Regulation of the Expression of the H-2 Linked Low Molecular Weight Proteins (LMP)....Pages 69-73
Quantitation of Ia Antigens on Normal and Leukemic Human Lymphocytes....Pages 75-79
Use of Monoclonal Antibodies for Studies of Anti-Ia Receptor Idiotypes....Pages 81-90
A Recombinatorial Event Separating the Immune Response Genes for LDH-B and MOPC-173: Implications for a New Model of I Region Gene Organization....Pages 91-95
Expression of Ia Antigens and Ir Gene Function During Differentiation of Bone Marrow Derived Macrophage....Pages 97-101
The IR-THY-1 Genes: Possible Mechanism of Their Effect....Pages 103-107
Complementing IR-Genes Located in the I-A Subregion and between the S and D Regions are Required for the Response to TNP-Ficoll....Pages 109-113
Front Matter....Pages 115-115
Ia Oligosaccharide Structure and Its Relation to Differential Recognition of Ia....Pages 117-127
Biosynthesis and Genetics of Ia Antigens and Their Associated Invariant Chain....Pages 129-133
Front Matter....Pages 135-146
Biochemical Characterization of the Murine Invariant Polypeptide and a 23,000 Dalton Ia d Encoded Polypeptide....Pages 115-115
Identification of an Invariant Chain δ of Murine Class II Antigens and its Relationship to the Invariant Chain γ (Ii)....Pages 147-151
Molecular Heterogeneity of Ia Antigengs: Novel Components and Complexes....Pages 153-157
Partial Chemical Characterization of T Lymphocyte I-Region Associated Antigens....Pages 159-168
Three Distinct Human Ia Molecules Isolated from a DR5 Homozygous Lymphoblastoid Cell Line....Pages 169-173
The Human “Invariant” Chain: Structural Characterization....Pages 175-184
Two-Dimensional Gel Analyses of HLA-DR and HLA-DS Molecules....Pages 185-190
Partial Structural Characterization of Human SB Antigens....Pages 191-195
Two Alpha Chains and Three Beta Chains of Human Ia Antigens....Pages 197-201
Isolation and Characterization of I Region Genes from the Major Histocompatibility Complex of the Mouse....Pages 203-207
Structure and Expression of the Murine Ia α Chains....Pages 209-215
Extensive Restriction Site Polymorphism Surrounding a Single Copy I-A β Gene....Pages 217-221
Analysis of the Human Ia Antigens by Gene Cloning....Pages 223-231
The Cloning and Structure of the Heavy Chain Gene of HLA-D(R)....Pages 233-242
Front Matter....Pages 243-247
Determinant Selection vs Clonal Deletion Models of Immune Response Gene Function....Pages 249-249
Absence of Ir -Gene Control in T-Cell Responses Restricted By Allogeneic Mhc Molecules....Pages 251-261
Both Low and High Responder Myoglobin-Specific T Cells, Tolerant to F 1 Help High But Not Low Responder B Cells....Pages 263-267
IR Gene Control as a Consequence of Holes in the Antigen Specific Repertoire of T lymphocytes....Pages 269-275
Ia Restriction Elements and Epitopes of Insulin Appear to be Recognized by Mouse T cells as Functional Units....Pages 277-281
Molecular Aspects of the Processing and Presentation of Avidin by Macrophages to T Lymphocytes....Pages 283-287
Front Matter....Pages 289-293
The Effect of Antigen and Ia Molecule Interaction on Immune Response Gene Control....Pages 249-249
T Cells with Differing Specificity Exist for a Single Determinant on Lysozyme....Pages 295-304
Hierarchical Relationships Among Epitopes: Only Certain Potentially Utilizable Epitopes on Protein Antigens are Actually Presented in a Particular Haplotype....Pages 305-309
Antigen-Specific Suppressor T Cells as One Mode of Expression of Immune Response Genes....Pages 311-315
Assessment of the Role of T Lymphocytes and Antigen Presenting Cells in the GAT Nonresponsiveness of SJL and DBA/1 Mice....Pages 317-325
Mechanism of H-2-Controlled Interaction Between LDH B - Specific Helper and Suppressor T Cells....Pages 327-331
Dissociation of Cellular and Humoral Immune Responsiveness to GAT....Pages 333-337
T Cell Function in Allotype Linked and H-2 Linked Immune Response to Insulin in Mice....Pages 339-347
H-2-Linked IR Gene Control of H-2 Unrestricted Cytotoxic T Lymphocytes....Pages 349-353
Immune Response Gene Effects in Cytotoxic T Cell Responses as a Consequence of Self Tolerance....Pages 355-359
Involvement of Syngeneic Ia in T Cell Responses to Class I Alloantigens....Pages 361-365
Control of Cytotoxic T-Lymphocyte Responses By Class-I and Class-II H-2 Molecules, Studied with H-2 Mutants....Pages 367-375
Characterization of “Veto” Cells that Cause Nonresponsiveness to Minor Histocompatibility Antigens....Pages 377-381
Interactive Control of Cytotoxic T Cell Responses to H-Y by H-2 and Non H-2 Ir Genes....Pages 383-387
Graft-Versus-Host-Associated Immune Suppression Involves in Vivo Recognition of Allogeneic I-A Determinants....Pages 389-393
Genetic Regulation of the Cytolytic T Lymphocyte Response to Influenza Viruses....Pages 395-399
Front Matter....Pages 401-405
Ir Genes, Adaptive Differentiation and Self-Recognition....Pages 407-407
The Contributions of the Developmental and Priming Environments to the Expression of the T Cell Receptor Repertoire....Pages 409-418
Ia Antigens as Restriction Molecules in Ir -Gene Controlled T-Cell Proliferation....Pages 419-423
Functional Evidence for Two Antigen Presentation Sites for a Single I-A Molecule....Pages 425-431
Front Matter....Pages 433-437
The Effect of Nominal Antigen and Ia Molecule Concentrations on the Magnitude of the Proliferative Response of T Cell Clones....Pages 407-407
Differential Requirements of Ia+ Accessory Cells for T Cell Activation....Pages 439-443
I-Region-Controlled Sugar Inhibition of T-B Collaboration....Pages 445-449
Ia Antigens in Cell Collaboration: Studies Using the B6.C-H-2 bm12 Mutant....Pages 451-455
Cloned T Cell Lines Do Not Discriminate Between Self Ia Molecules on B Cells and Antigen Presenting Cells....Pages 457-465
Do T Cells Recognize the Same Ia Epitopes on Antigen Presenting Cells and on B Cells?....Pages 467-472
 Ir Gene Regulation of The T Cell Dependent Activation of Distinct B Cell Subpopulations....Pages 473-477
Functions of Helper T Cell Hybridomas in B Cell Antibody Responses....Pages 479-483
Genetic Restriction of Polyclonal Stimulation of B Cell Proliferation by Antigen-Specific T Cell Clones....Pages 485-489
H-2 Class I and Class II Alloantigens as Triggering Stimuli of Suppressor T Cells....Pages 491-495
Susceptibility of Allo-Ia Specific T Lymphocytes to Unresponsiveness in Neonatal Tolerance....Pages 497-501
Induction of I-J Restrictions on Suppressor Cells....Pages 503-507
Activation of suppressor cells is genetically restricted by the I-J Subregion....Pages 509-514
Immunogenetic Aspects of Cellular and Humoral Autoimmunity to Acetylcholine Receptor....Pages 515-520
Front Matter....Pages 521-526
Multiple Restriction Sites Per la Molecule Recognized by T Cell Clones....Pages 527-527
Multiple Genes Control Human Immune Responses....Pages 529-533
Analysis of the T Cell Recognition System Using (T,G)-A--L Specific Helper T Cell Lines....Pages 535-539
Recognition of Self- or Allo-I-A Molecules by Cloned T Cells : An Analysis Using Monoclonal Anti-Ia Antibodies....Pages 541-546
Identification of H-2-Restricted Suppressor T Cell Factors Specific for L-Glutamic Acid 50 -L-Tyrosine 50 (GT) and L-Glutamic Acid 60 -L-Alanine 30 -L-Tyrosine 10 (GAT)....Pages 547-551
Comparative Analysis of a Monoclonal Antigen-Specific T Suppressor Factor Obtained from Supernatant, Membrane or Cytosol of a T-Cell Hybridoma....Pages 553-563
Front Matter....Pages 565-568
Characterization of an Antigen-Specific Suppressor Factor Generated by Cell-Free Translation....Pages 527-527
Functional Roles of Two Polypeptide Chains that Compose an Antigen-Specific Suppressor T Cell Factor....Pages 569-573
The MHC Restriction of a Monoclonal Antigen-Specific I-J + TsF 2 Maps to a Location Outside the I-J Subregion....Pages 575-583
Monoclonal Antibodies to Antigen Specific Factors — A New Tool for their Analysis....Pages 585-588
Epitope Organizations of I Region Products Associated with Antigen-Specific Augmenting and Suppressor T Cell Factors....Pages 589-597
Front Matter....Pages 599-607
 Ir -Genes: Quo Usque Tandem?....Pages 609-609
Back Matter....Pages 611-617
....Pages 619-621