Investigation and Stimulation of Immunity in Cancer Patients

Front Matter....Pages I-IX
Introduction....Pages 1-2
Front Matter....Pages 3-3
Selective Activation of T Lymphocytes. Its Possible Application in the Immunomanipulation of Tumours....Pages 5-11
Immunological Reactivity of Human Recipients of Syngeneic and Allogeneic Marrow Grafts....Pages 12-16
Immunological Studies in Acute Leukemia....Pages 17-24
Primary and Secondary Immune Responses in the Evaluation of Immunocompetence and Prognosis in Cancer Patients....Pages 25-36
Delayed-Hypersensitivity Reactions in Patients with Cancer....Pages 37-41
Nonspecific Immune Responses in Hematosarcomas and Acute Leukemias....Pages 42-53
Kinetics of Specific Cell-Mediated Immune Response in Cancer-Bearing Hosts....Pages 54-57
Technical and Interpretative Problems with Immunofluorescence....Pages 58-66
Patterns of Cellular Immunity in Malignant Melanoma....Pages 67-78
Lymphocyte-Defined Histocompatibility Differences as a Model for Tumor Antigens....Pages 79-83
Cell-Mediated Immunity to Human Solid Tumors: in vitro Detection by Lymphocyte Blastogenic Responses to Cell-Associated and Solubilized Tumor Antigens....Pages 84-96
Cell-Mediated and Humoral Immune Response to Acute Leukemia Cells and Soluble Leukemia Antigen-Relationship to Immunocompetence and Prognosis....Pages 97-112
Lymphocyte Cytotoxicity in Human Acute Leukemia....Pages 113-117
Lymphocyte-Mediated Cytotoxicity and Tumor Immunity....Pages 118-121
Cell-Mediated Immunity in Allogeneic and Tumor-Systems: Nature of the Cells Involved in Killing Target Cells....Pages 122-126
Inhibition of Leukocyte Migration in Man....Pages 127-128
Effect of Autologous Serum on in vitro Inhibition of Leukocyte Migration by Autochthonous Tumor Extracts from Human Patients....Pages 129-132
Serum Inhibitory Factors in Acute Leukemia....Pages 133-139
Delayed Hypersensitivity Response toward Autochthonous Tumor Extracts....Pages 140-146
Front Matter....Pages 147-147
Experimental Screening for “Systemic Adjuvants of Immunity” Applicable in Cancer Immunotherapy....Pages 149-165
Experimental Screening of Systemic Adjuvants Extracted from Mycobacteria....Pages 166-172
Chemical Structure of Mycobacterial Cell Walls....Pages 173-178
Water-Soluble Immuno-Adjuvants from the Cell Wall of Mycobacterium Smegmatis ....Pages 179-182
Stimulation of T Cell Activity by a Methanol-Extraction Residue (MER) of BCG....Pages 183-189
Biological Properties of Non-Toxic Water-Soluble Immunoadjuvants from Mycobacterial Cells....Pages 190-195
Enhancement of Human Mixed-Lymphocyte Cultures by a Water-Soluble Adjuvant....Pages 196-200
Early Recovery of the Immune Response of a Specifically Depleted Cell Population under the Influence of Water-Soluble Adjuvant....Pages 201-206
An Adjuvant-Active Water-Soluble Substance (“Polysaccharide-Peptidoglycan”) from Mycobacterial Cells. Preparation by a Simple Extraction Technique....Pages 207-211
MAAF: A Fully Water-Soluble, Lipid-Free Fraction from BCG with Adjuvant and Antitumor Activity....Pages 213-213
Comparative Study of the Free Lipids of Eight BCG Daughter Strains....Pages 214-220
A Galactose Disaccharide from Immunoadjuvant Fractions of Mycobacterium Tuberculosis (Cell Wall and Wax D)....Pages 221-223
Summary of Working Session on the Mechanism of Action of Immunological Adjuvants....Pages 224-227
BCG and the Lympho-Reticuloendothelial System....Pages 228-238
Effect of Corynebacterium Parvum on Resistance to Experimental Leukemia in Relation to Genetic Modification of Immunoresponsiveness....Pages 239-243
The Influence of Mycobacterium Bovis and Corynebacterium Parvum on the Phospholipid Metabolism of Macrophages....Pages 244-250
Separation and Purification of Cord Factor (6,6′ Dimycoloyl Trehalose) from Wax C or from Mycolic Acids....Pages 251-258
Granuloma Induction and Stimulation of the Immune Response in Mice with Trehalose -6,6′-Dimycolate....Pages 259-261
Corynebacterium Parvum: An Immunomodulator....Pages 262-271
Nonspecific Effects of Corynebacteria on Systemic Immunity Responses....Pages 272-274
Front Matter....Pages 147-147
Immunostimulating Activity of Whole Cells, Cell-Walls and Fractions of Anaerobic Corynebacteria....Pages 275-293
Nonspecific Stimulation by Inactivated or Ultrasonicated Brucella Abortus....Pages 294-301
Increase of Brucella-Induced Immunostimulation by Administration in Combination with a Specific Antiserum....Pages 302-307
Alterations in Immune Response to Experimental Murine Tumor-Associated Antigens Following Administration of BCG or Polysaccharide from Proteus vulgaris....Pages 308-319
Cell-Mediated Immunity in AKR Mice Treated with Lentinan, a Fungal Polysaccharide....Pages 320-326
The Antitumor Effects of Interferon....Pages 327-329
Use of Double-Stranded Synthetic Polynucleotides in Amplifying Immunologically Induced Lymphocyte Proliferation....Pages 330-337
Immunoenhancing and Antitumor Effects of Agents that Elevate Endogenous Cyclic AMP Levels....Pages 338-344
BCG Immunotherapy of Pulmonary Deposits from Experimental Rat Tumors of Defined Immunogenicity....Pages 345-349
Specific and Nonspecific Immunotherapy: Use of BCG....Pages 350-351
Poly A. Poly U as an Adjunct to Surgery in the Treatment of Spontaneous Murine Mammary Adenocarcinoma....Pages 352-356
Combined Chemotherapy and Immunotherapy of Transplantable and Spontaneous Murine Leukemia in DBA/2 and AKR Mice....Pages 357-369
Modification of Immunogenicity in Experimental Immunotherapy and Prophylaxis....Pages 370-378
Aspects of the Immunology of the Tumor-Host Relationship and Responsiveness to Modified Lymphoma Cells....Pages 379-386
Use of Enzyme-Treated Cells in Immunotherapy of Leukemia....Pages 387-388
Active Immunotherapy of AKR Mouse Spontaneous Leukemia....Pages 389-393
Augmented Immunogenicity of Tumor Cell Homogenates Infected with Influenza Virus....Pages 394-400
Characterization and Purification of Rauscher Leukemia-Associated Transplantation Antigens....Pages 401-404
The in vivo Activity of Soluble Extracts Obtained from RC 19 Leukemia: Effect of the Method of Extraction....Pages 405-407
The Preferential Induction of Cell-Mediated Immunity and Some Preliminary Observations on its Application to Tumor Immunotherapy....Pages 408-414
Front Matter....Pages 147-147
Clinical Screening of Systemic Adjuvants of Immunity....Pages 415-420
BCG Vaccination and Leukemia Mortality....Pages 421-425
Immunologic Effects of BCG in Patients with Malignant Melanoma....Pages 426-433
Attempts at Immunotherapy of 100 Acute Lymphoid Leukemia Patients: Some Factors Influencing Results....Pages 434-448
Immunotherapy of Acute Myeloblastic Leukemia in Man....Pages 449-454
Acute Myeloblastic Leukemia: Replication of Avian Influenza Virus in Human Myeloblasts and First Attempt at Clinical Application....Pages 455-460
Preliminary Results of a Randomized Trial of BCG Immunotherapy in Burkitt’s Lymphoma....Pages 461-465
BCG Immunotherapy in the Treatment of Inoperable Carcinoma of the Lung....Pages 466-469
Effect of BCG Stimulation on the Growth Rate of Pulmonary Metastases in 3 Patients with Melanoma....Pages 470-472
Immunotherapy of a Solid Tumor (Melanoma) with BCG: A Comment on the Risks of Enhancement....Pages 473-475
BCG Stimulation of Immune Responsiveness in Patients with Malignant Melanoma....Pages 476-485
Clinical Results with Corynebacteria....Pages 486-487
A Clinical Trial of Autogenous Vaccines in the Treatment of Osteogenic Sarcoma....Pages 488-495
Immunization with Cultured Cell-BCG Mixtures....Pages 496-501
Back Matter....Pages 503-504