Intravenous Immunoglobulins: In The Third Millennium

Book Cover......Page 1
Half-Title......Page 2
Title......Page 4
Copyright......Page 5
Content......Page 6
List of Speakers and Chairpersons......Page 12
Forword......Page 23
Two Decacdes of Experience with Intravenous Immunoglobulin......Page 25
1 Manufacturing of Intravenous Immunoglobulin: challenges, Achievements and Opportunities......Page 27
2. Challenges and Achievements in Pathogen Safety of Intravenous Immunoglobulin......Page 32
3. Treatments Modalities and Clinical Eficacy of Replacement Therapies in Primary Immunodeficiency......Page 44
4. Immunomodulation by Intravenous Immunoglobulin: Idiopathic Thrombocytopenic Purpura as a Model......Page 52
5. Witnessing the Introduction and Use of Intravenous Immunoglobulin in Neurology......Page 59
6. Pharmacoeconomics of Intravenous Immunoglobulin Administration in Neurological Disorders: The US Experience......Page 62
7. Pharmacoeconomics of Intravenous Immunoglobulin for Polyneuropathies......Page 67
Intravenous Immunoglobulin in Immunodeficiencies and Severe Infection—Molecular Aspects and Clinical Use......Page 72
8. B-cell Maturation to Produce High-affinity Antibodies of Different Isotopes and its Abnormalities......Page 74
9. The Molecular Basis of Primary Immune Deficiency Diseases......Page 79
10. Safety in Intravenous Immunoglobulin Therapy......Page 92
11. Immunoglobulin Replacement by the Subcutaneous Route Using Preparations Licensed in for Administration by Other Routes......Page 98
12. The Use of Intranenous Immunoglobulin for Allogeneic Stem Cell Transplantations: The US Experience......Page 102
13. Intravenous Immunoglobulin for Bone Marrow Stem Cell Transplantation the European Experience......Page 106
14. Secondary Antibody Deficiency Following Ttreatment of Vasculitis: The Use of Intravenous Immunoglobulin......Page 112
15. Intravenous Immunoglobulin In the Prevention and Treatment of Severe Infections......Page 115
Immunomodulatory and Anti-inflammatory Potential of Intravenous Immunoglobulin......Page 123
16. Mechanisms of Intravenous Immunoglobulin in Autoimmune and Inflammatory Diseases......Page 124
17. Role of Intravenous Immunoglobulin in Reversing Glucocorticoid Insensitivity or Resistance......Page 130
18. Modulating the Balance of Activating and Inhibiting Fcγ Receptors: Mechanism of Intravenous Immunoglobulin Action......Page 137
19. Anti-inflammatory Effects of Intravenous Immunoglobulin: Fcγ receptor inhibition/blockade and non-Fcγ Receptor-mediated Mechanism......Page 142
20. Immune Modulation by Intravenous Immunoglobulin: Some Remarks on the Role of Fc Receptors......Page 147
21. Intravenous Immunoglobulin in Reactive Hemophagocytic Syndrome: A of Fcγ Receptor and Cytokine Modulation......Page 151
22. Anti-inflammatory Effects of Intravenous Immunoglobulin Through Modulation of Complement Activities......Page 157
23. Changes in Gene Expression Profile in the Muscles of Patients with Dermatomyositis and Inclusion Body Mysoitis After Therapy with Intravenous Immunoglobulin: A Microarray Analysis Correlating Gene Expression with Clinical Outcomes......Page 163
24. In Vitro Studies of Mechanisms of Action of Intravenous Immunoglobulin in Guillain-Barree Syndrome and Miller-Fisher Syndrome: A Review......Page 168
Intravenous Immunoglobulin for Autoimmune Dieseases of the Peripheral Nervous System......Page 175
25. The Immunological Rationale for Intravenous Immunoglobulin in Guillian-Barre Syndrome and Chronic Inflammatory Demylinating Polyradiculoneuropathy......Page 178
26. Intravenous Immunoglobulin for Guillain-Barre Syndrome and Chronic Inflammatory Demyelinating Polyradiculoneuropathy in Adult Patients......Page 187
27. Clinical Experience with Intravenous Immunoglobulin for Treatment of Pediatric Guillain-Barre Syndrome and Chronic Inflammatory Demyelinating Polyradiculoneuropathy......Page 197
28. Intravenous Immunoglobulin for Multifocal Motor Neuropathy......Page 202
29. Intravenous Immunoglobulin in ParaProteinemic Demyelinating Neuropathies......Page 205
30. Immunoglobulins in IgM Antimyelin-Associated Glycoprotein and Other Paraprotein and Other Paraproteinemic Neuropathies......Page 211
31. Intravenous Immunoglobulin for Myasthenia Gravis......Page 216
32. Intravenous Immunoglobulin in Polymyositis and Dermatomyositis......Page 219
33. Controlled Studies with High-Dose Intravenous Immunoglobulin in the Treatment of Inclusion Body Myositis......Page 224
Intravenous Immunoglobulin for Autoimmune Diseases of the Central Nervous System......Page 230
34. Immune Mechanism and Treatment Perspectives in Multiple Sclerosis......Page 232
35. A Review of Intravenous Immunoglobulin in Multiple Sclerosis......Page 239
36. Intravenous Immunoglobulin Treatment for Patients with Primary or Secondary Progressive Multiple Sclerosis......Page 245
37. What is the Effect of Intravenous Immunoglobulin for Treatment of Ralapsing-Remitting Multiple Sclerosis?......Page 252
38. High-dose Intravenous Immunoglobulin In the Treatment of Patients with Stiff Person Syndrome: A Controlled Study......Page 265
39. Intravenous Immunoglobulin in Acute Disseminated Encephalomyelitis......Page 276
The Use of Intravenous Immunoglobulin in Dermatology......Page 285
40. Intravenous Immunoglobulin in Dermatology......Page 287
41. The Use of Intravenous Immunoglobulin Therapy in of Autoimmune Mucocutaneous Blistering Diseases......Page 291
42. Treatment of Atopic Dermatitis, Urticaria and Psoriasis with Intravenous Immunoglobulin......Page 299
43. Intravenous Immunoglobulin in Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome......Page 305
44. Intravenous Immunoglobulin in the Treatment of  Vasculitis......Page 309
Emerging Applications for Intravenous Immunoglobulin......Page 320
45. Immunomodulation by Intravenous Immunoglobulin of Alloantibodies to Human Leukocyte Antigen: Clinical Aspect in Solid Organ Transplantation......Page 322
46. Role of Intravenous Immunoglobulin in the Mangement of Heart Failure......Page 329
47. Intravenous Immunoglobulin: Potential Role in the Management of Severe Acute Respiratory Syndrome......Page 339
48. Enchancement of the Immune Response to Mycobacterium Tuberculosis by High-dose Intravenous Immunoglobulin in Mice......Page 345
Potential Applications for Intravenous Immunoglobulin......Page 349
49. Intravenous Immunoglobulin for Treatment of Recurrent Miscarriage......Page 351
50. Epilepsy and the Immune System: Is there a Link......Page 356
51. Intravenous Immunoglobulin as an Immunomodulatory Agent in Systemic Lupus Eruthematosus and Lupus Nephritis......Page 364
52. Intravenous Immunoglobulin for Fibrosis, Atherosclerosis and Malignant Conditions......Page 368
Summeries of Poster Sessions......Page 374
53. Intravenous Immunoglobulin for Immune Deficiencies and Passive Immunization......Page 376
54. The Use of Intravenous Immunoglobulin in Hematology and Transplantation......Page 380
55. The of Intravenous Immunoglobulin in Neurology......Page 385
56. The Use of Intravenous Immunoglobulin for Dermatological Disorders......Page 391
57. The Use of Intravenous Immunoglobulin in Collagen Vascular and Heart Diseases......Page 396
58. Intravenous Immunoglobulin: Machanisms of Action......Page 399
59. Pathogen Safety and Tolerability of Intravenous Immunoglobulin......Page 403
60. Pharmacoeconomics and Evidence-based Medicine G.Antonini and A.Di Pasquale......Page 410
Index......Page 415