Intracerebral Hemorrhage Research: From Bench to Bedside

Front Matter....Pages i-xv
Front Matter....Pages 1-1
History of Preclinical Models of Intracerebral Hemorrhage....Pages 3-8
Comparison of Different Preclinical Models of Intracerebral Hemorrhage....Pages 9-14
Cerebral Amyloid Angiopathy-Related Microhemorrhages in Alzheimer’s Disease: A Review of Investigative Animal Models....Pages 15-17
Multiparametric Characterisation of the Perihemorrhagic Zone in a Porcine Model of Lobar ICH....Pages 19-23
Developing a Model of Chronic Subdural Hematoma....Pages 25-29
A Mouse Model of Intracranial Aneurysm: Technical Considerations....Pages 31-35
The Postpartum Period of Pregnancy Worsens Brain Injury and Functional Outcome After Cerebellar Hemorrhage in Rats....Pages 37-41
Hyperglycemia and Hemorrhagic Transformation of Cerebral Infarction: A Macroscopic Hemorrhagic Transformation Rat Model....Pages 43-48
Hemorrhagic Transformation Induced by Acute Hyperglycemia in a Rat Model of Transient Focal Ischemia....Pages 49-54
A Novel Preclinical Model of Germinal Matrix Hemorrhage Using Neonatal Rats....Pages 55-60
Front Matter....Pages 61-61
Intracranial Hemorrhage: Mechanisms of Secondary Brain Injury....Pages 63-69
Clot Formation, Vascular Repair and Hematoma Resolution After ICH, a Coordinating Role for Thrombin?....Pages 71-75
The Dual Role of Src Kinases in Intracerebral Hemorrhage....Pages 77-81
Brain Arteriovenous Malformation Pathogenesis: A Response-to-Injury Paradigm....Pages 83-92
The Evolving Landscape of Neuroinflammation After Neonatal Hypoxia-Ischemia....Pages 93-100
Red Blood Cell Lysis and Brain Tissue-Type Transglutaminase Upregulation in a Hippocampal Model of Intracerebral Hemorrhage....Pages 101-105
Cytoprotective Role of Haptoglobin in Brain After Experimental Intracerebral Hemorrhage....Pages 107-112
Effects of Aging on Autophagy After Experimental Intracerebral Hemorrhage....Pages 113-117
Effects of Gender on Heart Injury After Intracerebral Hemorrhage in Rats....Pages 119-122
Iron Accumulation and DNA Damage in a Pig Model of Intracerebral Hemorrhage....Pages 123-128
Front Matter....Pages 61-61
Subarachnoid Hemorrhage Causes Pulmonary Endothelial Cell Apoptosis and Neurogenic Pulmonary Edema in Mice....Pages 129-132
Hemoglobin Expression in Neurons and Glia After Intracerebral Hemorrhage....Pages 133-137
Front Matter....Pages 139-139
Isoflurane Preconditioning Affords Functional Neuroprotection in a Murine Model of Intracerebral Hemorrhage....Pages 141-144
The Neuroprotective Effects of Cyclooxygenase-2 Inhibition in a Mouse Model of Aneurysmal Subarachnoid Hemorrhage....Pages 145-149
Sonic Hedgehog Agonist Fails to Induce Neural Stem Cell Precursors in a Porcine Model of Experimental Intracranial Hemorrhage....Pages 151-154
NC1900, an Arginine Vasopressin Analogue, Fails to Reduce Brain Edema and Improve Neurobehavioral Deficits in an Intracerebral Hemorrhagic Stroke Mice Model....Pages 155-159
Geldanamycin Reduced Brain Injury in Mouse Model of Intracerebral Hemorrhage....Pages 161-165
Combined Systemic Thrombolysis with Alteplase and Early Hyperbaric Oxygen Therapy in Experimental Embolic Stroke in Rats: Relationship to Functional Outcome and Reduction of Structural Damage....Pages 167-172
Neutrophil Depletion Diminishes Monocyte Infiltration and Improves Functional Outcome After Experimental Intracerebral Hemorrhage....Pages 173-178
Hydrogen Inhalation is Neuroprotective and Improves Functional Outcomes in Mice After Intracerebral Hemorrhage....Pages 179-183
Deferoxamine Reduces Cavity Size in the Brain After Intracerebral Hemorrhage in Aged Rats....Pages 185-190
Post-treatment with SR49059 Improves Outcomes Following an Intracerebral Hemorrhagic Stroke in Mice....Pages 191-196
Deferoxamine Affects Heat Shock Protein Expression in Heart after Intracerebral Hemorrhage in Aged Rats....Pages 197-200
Neuroprotection by Melatonin after Germinal Matrix Hemorrhage in Neonatal Rats....Pages 201-206
Endothelin Receptor-A (ET a ) Inhibition Fails to Improve Neonatal Hypoxic-Ischemic Brain Injury in Rats....Pages 207-212
FTY720 is Neuroprotective and Improves Functional Outcomes After Intracerebral Hemorrhage in Mice....Pages 213-217
Thrombin Preconditioning Reduces Iron-Induced Brain Swelling and Brain Atrophy....Pages 219-223
Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats....Pages 225-230
Effects of Recombinant Osteopontin on Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Rats....Pages 231-236
Protective Effect of Hydrogen Gas Therapy After Germinal Matrix Hemorrhage in Neonatal Rats....Pages 237-241
Front Matter....Pages 139-139
Pretreatment with Normobaric and Hyperbaric Oxygenation Worsens Cerebral Edema and Neurologic Outcomes in a Murine Model of Surgically Induced Brain Injury....Pages 243-251
Beneficial Effect of Hyperbaric Oxygenation After Neonatal Germinal Matrix Hemorrhage....Pages 253-257
Thrombin Preconditioning Attenuates Iron-Induced Neuronal Death....Pages 259-263
Granulocyte Colony-Stimulating Factor Treatment Provides Neuroprotection in Surgically Induced Brain Injured Mice....Pages 265-269
Tamoxifen Treatment for Intracerebral Hemorrhage....Pages 271-275
Prostaglandin E 2 EP 1 Receptor Inhibition Fails to Provide Neuroprotection in Surgically Induced Brain-Injured Mice....Pages 277-281
Mucosal Tolerance to Brain Antigens Preserves Endogenous TGFβ-1 and Improves Neurological Outcomes Following Experimental Craniotomy....Pages 283-287
Effects of Progesterone and Testosterone on ICH-Induced Brain Injury in Rats....Pages 289-293
Drug Repurposing for Vascular Protection After Acute Ischemic Stroke....Pages 295-298
Erythropoietin Attenuates Inflammatory Factors and Cell Death in Neonatal Rats with Intracerebral Hemorrhage....Pages 299-305
Protective Effects of Hydrogen on Fetal Brain Injury During Maternal Hypoxia....Pages 307-311
Front Matter....Pages 313-313
Neuroglobin Expression in Human Arteriovenous Malformation and Intracerebral Hemorrhage....Pages 315-319
Intracerebral Hemorrhage and Meteorological Factors in Chongqing, in the Southwest of China....Pages 321-325
Timing Pattern of Onset in Hypertensive Intracerebral Hemorrhage Patients....Pages 327-331
“Weekend Effects” in Patients with Intracerebral Hemorrhage....Pages 333-336
Disparities in Medical Expenditure and Outcomes Among Patients with Intracranial Hemorrhage Associated with Different Insurance Statuses in Southwestern China....Pages 337-341
Clinical Analysis of Electrolyte Imbalance in Thalamic Hemorrhage Patients Within 24 H After Admission....Pages 343-348
Characteristics of Pulse Pressure Parameters in Acute Intracerebral Hemorrhage Patients....Pages 349-352
Electrocardiographic Abnormalities in Patients with Intracerebral Hemorrhage....Pages 353-356
ECG Change of Acute Subarachnoid Hemorrhagic Patients....Pages 357-359
Front Matter....Pages 313-313
Diagnosis and Treatment of Hemorrhagic Pituitary Adenomas....Pages 361-365
Characteristics of Acute Cerebral Hemorrhage with Regard to Lipid Metabolism and Glycometabolism Among Different Age Groups....Pages 367-371
Front Matter....Pages 373-373
The Role of a High Augmentation Index in Spontaneous Intracerebral Hemorrhage to Prognosticate Mortality....Pages 375-379
Effect of Minimally Invasive Aspiration in Treatment of Massive Intracerebral Hemorrhage....Pages 381-382
Retrospective Analysis of the Predictive Effect of Coagulogram on the Prognosis of Intracerebral Hemorrhage....Pages 383-385
Risk Factors of Early Death in Patients with Hypertensive Intracerebral Hemorrhage During Hospitalization....Pages 387-391
Effects of Early Serum Glucose Levels on Prognosis of Patients with Acute Intracerebral Hemorrhage....Pages 393-397
Prognosis Study of 324 Cases with Spontaneous Intracerebral Hemorrhage in Chongqing, China....Pages 399-402
Retrospective Analysis of the Predictive Effect of Routine Biochemical Results on the Prognosis of Intracerebral Hemorrhage....Pages 403-406
Front Matter....Pages 407-407
Alteplase (rtPA) Treatment of Intraventricular Hematoma (IVH): Safety of an Efficient Methodological Approach for Rapid Clot Removal....Pages 409-413
Decompressive Hemi-craniectomy Is Not Necessary to Rescue Supratentorial Hypertensive Intracerebral Hemorrhage Patients: Consecutive Single-Center Experience....Pages 415-419
Intravascular Hypothermia for Acute Hemorrhagic Stroke: A Pilot Study....Pages 421-424
Use of Intralesional tPA in Spontaneous Intracerebral Hemorrhage: Retrospective Analysis....Pages 425-428
Endoscopic Surgical Treatment for Pituitary Apoplexy in Three Elderly Patients over the Age of 80....Pages 429-433
Proton Pump Inhibitor Prophylaxis Increases the Risk of Nosocomial Pneumonia in Patients with an Intracerebral Hemorrhagic Stroke....Pages 435-439
Back Matter....Pages 441-453