Integration of Mitochondrial Function

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Diffusional Integration of Mitochondrial Function: Lateral Diffusion of Proteins in Energy Transduction....Pages 3-13
Diffusion and Collision in Cytochrome c -Mediated Electron Transport....Pages 15-22
Is Electron Transfer Mediated by Random Diffusion Alone?....Pages 23-31
Role of Ubiquinone Diffusion in Mitochondrial Electron Transfer....Pages 33-52
Physical Constraints on Lateral Diffusion and Ubiquinone-Mediated Mitochondrial Electron Transport....Pages 53-61
Inhibition of Bovine Heart Mitochondrial NADH — Ubiquinone Reductase by Tinopal AN, A Cationic Benzoxazole....Pages 63-70
Topographical Changes in Cytochrome C Oxidase in the Soluble and Membrane-Bound Enzyme as Probed by Antibodies to Subunit V and the Whole Enzyme....Pages 71-77
Multiple Forms of Cytochrome C Oxidase Observed in Heart Tissue, Myocytes, and Mitochondria by Fourier Transform Infrared Spectroscopy....Pages 79-86
Functional Importance of Mitochondrial Cardiolipin in Yeast Cytochrome c Oxidase Activity....Pages 87-94
Lateral Diffusion of Mitochondrial F 1 F 0 ATP Synthase: A Random Collision Model for Proton Transfer and ATP Synthesis....Pages 95-101
Front Matter....Pages 103-103
Thermodynamics and Control of Proton-Motive Free-Energy Transduction....Pages 105-119
The Mechanism of Uncoupling of Oxidative Phosphorylation....Pages 121-134
Upper and Lower Limits of Charge, Proton and ATP Stoichiometries of Oxidative Phosphorylation....Pages 135-154
ATP/2e − Stoichiometries for the Coupling Sites of Mitochondrial Oxidative Phosphorylation: Evaluation by Equilibrium and Non-Equilibrium Thermodynamics....Pages 155-168
Nonequilibrium Thermodynamics and Cellular Bioenergetics....Pages 169-175
The Near-Equilibrium Thermodynamics Approach to Living Systems....Pages 177-196
The H + /e − Forces and Stoichiometries of the Mitochondrial Respiratory Chain....Pages 197-203
Variation of Efficiency with Free Energy Dissipation in Theoretical Models of Oxidative Phosphorylation and Cytochrome Oxidase....Pages 205-212
Analysis of Mechanisms of Free Energy Coupling and Uncoupling by Inhibitor Titrations....Pages 213-219
Front Matter....Pages 221-221
Mechanisms Stabilizing the Protonmotive Force in Respiring Mitochondria....Pages 223-234
Front Matter....Pages 221-221
Regulation of Respiration and Pyruvate Dehydrogenase in Isolated Cardiac Myocytes and Hepatocytes....Pages 235-244
Control Analysis of Cellular Metabolism: Application to Gluconeogenesis in Rat-Liver Cells....Pages 245-257
Mitochondrial Volume Control....Pages 259-278
Organization of the Mitochondrial Matrix....Pages 279-288
Competition Between Electron Transfer and ATPase in Generating Steady-State Protonmotive Force and Phosphorylation Potential....Pages 289-296
Control of Respiration and ATP Hydrolysis in Uncoupled Mitochondria....Pages 297-304
Voltage-Dependent Channels are Present in the Inner Membrane of Mitochondria....Pages 305-311
The Kinetics of Inorganic Phosphate Uptake and Utilization by Chick Heart Mitochondria....Pages 313-323
Possible Role of Membrane-Enzyme Interactions in Activation of Pyruvate Carboxylation and Decarboxylation in Mitochondria....Pages 325-332
Duramycin Effects on Mitochondrial Structure and Function....Pages 333-340
Mitochondrial Compartmentation of Branched Chain Amino Acid Catabolism: Is the Aminotransferase A Mitochondrial Enzyme?....Pages 341-348
Mitochondrial Lactate Dehydrogenase....Pages 349-356
Lithium Ion is a Competitive Inhibitor of the Na + Selective Na + /H + Antiporter from Mitochondria....Pages 357-364
Front Matter....Pages 365-365
Mitochondrial Membrane Potential and pH Gradient in Hypoxic Hepatocytes: Characteristics of the Neahypoxic State....Pages 367-377
Blebbing, Cytosolic Free Calcium, and Mitochondrial Membrane Potential Following Toxic and Anoxic Injury in Hepatocytes....Pages 379-391
Physiological Significance of a New Adenine Nucleotide Transport Mechanism in Liver Mitochondria....Pages 393-404
Integration of Mitochondrial Function with High Aerobic Glycolysis in Tumors: Role of Hexokinase Binding to the Outer Mitochondrial Membrane....Pages 405-411
Cytosolic Free Calcium and Myocardial Cell Injury....Pages 413-420
Relationships Between Extracellular pH, Intracellular pH, and Cell Injury During ‘Chemical Hypoxia’....Pages 421-428
Regulation of the Mitochondrial ATPase In Situ in Slow and Fast Heart-Rate Hearts....Pages 429-436
Front Matter....Pages 365-365
The Role of Ionized Cytosolic Calcium ([Ca 2+ ] i ) in Acute and Chronic Cell Injury....Pages 437-444
Succinate and Oxygen Dependence of Mitochondrial Function in Neonatal Hepatocytes....Pages 445-450
Cyclic Nucleotides and Mitochondrial Functions at Birth....Pages 451-458
Simultaneous Determination of Proton Concentration in Two Compartments....Pages 459-465
Tetraphenylphosphonium Ion Distribution in Human Fibroblasts as a Function of In Vitro Aging....Pages 467-472
Front Matter....Pages 473-473
The Role of Calcium in the Control of Cell Function....Pages 475-485
Hormonal Control of Ca 2+ -Sensitive Intramitochondrial Enzymes in Mammalian Tissues....Pages 487-496
Effect of Mitochondrial Ca ++ on Hepatic Aspartate Formation and Gluconeogenic Flux....Pages 497-510
Glucagon Stimulation of Mitochondrial Metabolism....Pages 511-516
The Function of the Uncoupling Protein in the Intact Brown Fat Cell....Pages 517-526
Hormonal Regulation of the Hepatic 2-Oxoglutarate Dehydrogenase Complex....Pages 527-533
Ca 2+ -Dependent NAD(P) + -Induced Alterations in Membrane Permeability of Rat Liver Mitochondria....Pages 535-542
Integrated Mitochondrial and Microsomal Regulation of Free Ca 2+ in Permeabilized Insulinoma Cells....Pages 543-550
The Estimation of the In Vivo Mitochondrial Free Ca 2+ Concentration....Pages 551-558
Front Matter....Pages 559-559
Metabolic Zonation of Carbohydrate Metabolism in the Liver....Pages 561-579
Acinar Compartmentation of Amino Acid and Ammonia Metabolism and Its Functional Significance....Pages 581-589
Role of Mitochondria in Zone-Specific Toxicity to the Liver Lobule....Pages 591-604
Role of Calcium in Regulation of Hepatic Oxygen Uptake....Pages 605-616
Heterogeneity of Energy Metabolism in the Kidney....Pages 617-622
Metabolic Key to Hypoxia Tolerance: Loss of Regulatory Links Between the Electron Transfer System and Glycolysis....Pages 623-627
Front Matter....Pages 559-559
Glucagon Actions in Perfused Liver are Oxygen Dependent....Pages 629-636
Microzonation of Metabolism Associated with Mitochondrial Distribution in Cells....Pages 637-642
Back Matter....Pages 643-664