Instant Clinical Pharmacology

Introduction......Page 6
What is Clinical Pharmacology?......Page 7
1 Clinical pharmacokinetics......Page 9
General Overview of Pharmacokinetics......Page 10
Pharmacokinetics......Page 12
Drug Clearance......Page 14
Volume of Distribution......Page 16
The Half-Life......Page 18
Oral Availability......Page 20
Protein Binding......Page 22
pH and Pharmacokinetics......Page 24
2 Factors affecting dosing......Page 27
Drug Metabolism......Page 28
Saturable Metabolism......Page 30
Pharmacogenetics......Page 32
Dosing in Liver Disease and Other Disease States......Page 34
Renal Drug Elimination......Page 36
Dosing in Renal Impairment......Page 38
Dosing in the Elderly......Page 40
Dosing in Children......Page 42
Drugs in Pregnancy......Page 44
Drugs in Human Milk......Page 46
3 Altered drug effect......Page 49
Adverse Drug Reactions......Page 50
Drug-Induced Allergy......Page 52
Adverse Drug Events......Page 54
Preventing Adverse Drug Events......Page 56
Drug/Drug Interactions......Page 58
Inducers of Drug Metabolism......Page 60
Inhibitors of Drug Metabolism......Page 61
Drug/Food Interactions......Page 62
4 Pharmacovigilance......Page 65
Drug Development......Page 66
Therapeutic Drug Monitoring (TDM)......Page 68
Drugs Involved in Therapeutic Drug Monitoring......Page 70
Overdose/Poisoning......Page 72
Common Poisonings......Page 74
Pharmacological Aspects of Drug Dependence......Page 76
5 Optimal therapeutics......Page 79
Principles of Drug Action......Page 80
Applied Pharmacology......Page 82
Compliance with Medication......Page 84
Principles of Therapeutics......Page 86
Patients and their Drugs......Page 88
The Drug Profile......Page 90
Evidence-based Medicine......Page 92
Pharmacoeconomics......Page 94
Drug Information/ Resources......Page 96
6 Appendix......Page 99
Important Equations in Pharmacology......Page 100
The Pharmacokinetic Triangle......Page 101
Glossary/Abbreviations......Page 102
Test Questions......Page 104
Test Answers......Page 106
Index......Page 109