Inhibition of Polyamine Metabolism. Biological Significance and Basis for new Therapies

Content: 
Front Matter, Page iii
Copyright, Page iv
Preface, Pages xi-xii, Peter P. McCann, Anthony E. Pegg, Albert Sjoerdsma
Introduction: Polyamine Metabolism, Pages xiii-xvi, Peter P. McCann, Anthony E. Pegg, Albert Sjoerdsma
1 - Inhibition of Basic Amino Acid Decarboxylases Involved in Polyamine Biosynthesis, Pages 1-31, PHILIPPE BEY, CHARLES DANZIN, MICHEL JUNG
2 - Pharmacologic Interference with Enzymes of Polyamine Biosynthesis and of 5′-Methylthioadenosine Metabolism, Pages 33-48, ANTHONY E. PEGG, H. GUY WILLIAMS-ASHMAN
3 - Inhibition of Enzymes Oxidizing Polyamines, Pages 49-77, N. SEILER
4 - Molecular and Cellular Functions of the Polyamines, Pages 79-105, LAURENCE J. MARTON, DAVID R. MORRIS
5 - The Use of Inhibitors to Study the Biochemistry and Molecular Biology of Polyamine Biosynthesis and Uptake, Pages 107-119, ANTHONY E. PEGG
6 - Inhibitors of Polyamine Biosynthesis: Cellular and in Vivo Effects on Tumor Proliferation, Pages 121-140, PRASAD S. SUNKARA, STEPHEN B. BAYLIN, GORDON D. LUK
7 - Polyamine Inhibition in Vivo and in Organ Growth and Repair, Pages 141-164, CHARLES DANZIN, PIERRE S. MAMONT
8 - Polyamine Synthesis Inhibitors Act as both Inducers and Suppressors of Cell Differentiation, Pages 165-186, OLLE HEBY, GORDON D. LUK, JOEL SCHINDLER
9 - The Contragestational Effects of Ornithine Decarboxylase Inhibition, Pages 187-202, J.R. FOZARD
10 - Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis, Pages 203-248, CARL W. PORTER, JUHANI JÄNNE
11 - Inhibition of Carcinogenesis by Inhibitors of Putrescine Biosynthesis, Pages 249-258, AJIT K. VERMA, R.K. BOUTWELL
12 - Inhibition of Polyamine Biosynthesis in Microorganisms, Pages 259-275, ALAN J. BITONTI, PETER P. MCCANN
13 - Inhibition of Viral Polyamine Biosynthesis, Pages 277-304, A. STANLEY TYMS, JOHN D. WILLIAMSON
14 - Inhibition of Polyamine Biosynthesis in Plants and Plant Pathogenic Fungi, Pages 305-316, ROBERT D. SLOCUM, ARTHUR W. GALSTON
15 - Parasitic Protozoa and Polyamines, Pages 317-344, CYRUS J. BACCHI, PETER P. McCANN
16 - Clinical Aspects of Inhibition of Ornithine Decarboxylase with Emphasis on Therapeutic Trials of Eflornithine (DFMO) in Cancer and Protozoan Diseases, Pages 345-364, PAUL J. SCHECHTER, JOHN L.R. BARLOW, ALBERT SJOERDSMA
Index, Pages 365-371