Infection and Local Treatment in Orthopedic Surgery

Front Matter....Pages I-XIV
The Socio-economic Burden of Musculoskeletal Infections....Pages 1-10
Front Matter....Pages 11-11
Epidemiology and Classification of Septic Total Hip Replacement....Pages 13-20
Early Radiological Diagnosis and Differential Diagnosis of Infection in Orthopaedic Surgery....Pages 21-32
Bacterial Strategies of Implant Colonization and Resistance....Pages 33-38
Pathological Findings of Septic Loosening....Pages 39-48
Antimicrobial Prophylaxis in Orthopaedic Surgery....Pages 49-57
The Limits of Systemic Antibiotics in Device-related Infections....Pages 58-61
Antibiotic Bone Cement as a Prophylactic Means in Joint Replacement Surgery....Pages 62-66
The Limits of the Local Antibiotic Therapy....Pages 67-72
The Role of Suppressive Surgery....Pages 73-76
Front Matter....Pages 77-77
PMMA as Drug Delivery System and in vivo Release from Spacers....Pages 79-91
Antibiotic Cement Spacers in Total Hip and Total Knee Arthroplasty: Problems, Pitfalls, and Avoiding Complications....Pages 92-111
The Preformed Spacers: From the Idea to the Realization of an Industrial Device....Pages 112-120
Fatigue and Wear Characterization of the Preformed Hip Spacer....Pages 121-127
Fatigue Characterisation of the Preformed Knee Spacer....Pages 128-135
Surface Analysis of the Spacer Before and After the Clinical Use....Pages 136-147
Bone Loss: Does Use of the Spacer Affects it?....Pages 148-153
Antibiotic Impregnated Bone Grafts — What Do We Know?....Pages 154-159
Antibiotic-loaded Bone Allograft: Personal Experience....Pages 160-169
Antibiotic Loaded Cement: From Research to Clinical Evidence....Pages 170-175
Front Matter....Pages 177-177
The Management of Infection in THA: A Historical Perspective....Pages 179-188
Girdlestone Arthroplasty after Hip Prosthesis Infection — A Two-stage Revision....Pages 189-193
One-stage Non-cemented Revision of Septic Hip Prosthesis Using Antibiotic-loaded Bone Graft....Pages 194-200
Two-stage Revision of Infected Total Hip Arthroplasty. Comparison Between a Custom-made and a Preformed Spacer....Pages 201-204
Two-stage Revision of Infected Total Hip Replacement Using a Preformed, Antibiotic-loaded Acrylic Cement Spacer....Pages 205-213
Two-stage Revision of Septic Hip Prosthesis with Uncemented Implants....Pages 214-230
Long-stem Preformed Spacers Followed by Uncemented Implants: A Solution for Wide Femoral Opening or Bone Loss in Two-stage Revision....Pages 231-242
Two-stage Revision Surgery in Septic Total Hip Arthroplasty....Pages 243-247
One-stage, Two-stage or Multi-stage Revision: the Reason of a Choice....Pages 248-257
Analysis of the Gait in Patients with Hip Spacers....Pages 258-263
Front Matter....Pages 265-265
Septic Knee Prosthesis Revision: A Challenging Surgery....Pages 267-271
Management of TKA Infection — One-stage Exchange....Pages 272-285
Antibiotic-loaded Bone Cement Spacers for the Two-stage Revision in Total Knee Replacement....Pages 286-293
Key Points in Two-stage Revision for Infected Knee Arthroplasty: Bone Loss, Quality of Life Between Stages and Surgical Approach at Second Stage....Pages 294-301
Two-stage Revision with Preformed Knee Spacers and Modular Knee Prosthesis....Pages 302-308
Arthrodesis for the Treatment of Severe Knee Disease....Pages 309-319
Arthrodesis and Amputation in Knee Joint Infections....Pages 320-327
Salvage Procedures in Exposed Septic Knee Prothesis....Pages 328-335
Front Matter....Pages 337-337
The Management of the Shoulder Prosthesis Infection....Pages 339-343
Shoulder Spacer as a Definitive Solution?....Pages 344-351
Front Matter....Pages 337-337
The Gentamicin-Vancomycin Spacer: A Pharmacological Study....Pages 352-358
Rationale of Nail Antibiotic Clothing and “ in vivo ” Animal Study....Pages 359-366
The Use of Antibiotic-loaded Spacers in Post-traumatic Bone Infection....Pages 367-376
The Use of Antibiotic-impregnated Cement in Infected Reconstructions after Resection for Bone Tumors....Pages 377-384
Local Antibiotic Therapy: Present and Future....Pages 385-395