In Vitro Neuronal Networks: From Culturing Methods to Neuro-Technological Applications

Front Matter ....Pages i-xv
Front Matter ....Pages 1-1
 Past, Present, and Future of Neuronal Models In Vitro  (Jason M. Keller, Monica Frega)....Pages 3-17
 In Vitro Models of Brain Disorders  (Joost le Feber)....Pages 19-49
 Neuronal Cultures and Nanomaterials  (Mattia Bramini, Anna Rocchi, Fabio Benfenati, Fabrizia Cesca)....Pages 51-79
Front Matter ....Pages 81-81
 Large-Scale, High-Resolution Microelectrode Arrays for Interrogation of Neurons and Networks  (Marie Engelene J. Obien, Urs Frey)....Pages 83-123
 Multisite Intracellular Recordings by MEA  (Micha E. Spira, Shun-Ho Huang, Nava Shmoel, Hadas Erez)....Pages 125-153
 From MEAs to MOAs: The Next Generation of Bioelectronic Interfaces for Neuronal Cultures  (Andrea Spanu, Mariateresa Tedesco, Sergio Martinoia, Annalisa Bonfiglio)....Pages 155-167
Front Matter ....Pages 169-169
 Scaling Spike Detection and Sorting for Next-Generation Electrophysiology  (Matthias H. Hennig, Cole Hurwitz, Martino Sorbaro)....Pages 171-184
 Burst Detection Methods  (Ellese Cotterill, Stephen J. Eglen)....Pages 185-206
 Reconstruction of Functional Connectivity from Multielectrode Recordings and Calcium Imaging  (Paolo Bonifazi, Paolo Massobrio)....Pages 207-231
 Open-Source Tools for Processing and Analysis of In Vitro Extracellular Neuronal Signals  (Mufti Mahmud, Stefano Vassanelli)....Pages 233-250
Front Matter ....Pages 251-251
 Active High-Density Electrode Arrays: Technology and Applications in Neuronal Cell Cultures  (Davide Lonardoni, Hayder Amin, Stefano Zordan, Fabio Boi, Aziliz Lecomte, Gian Nicola Angotzi et al.)....Pages 253-273
 Application of Microelectrode Array Approaches to Neurotoxicity Testing and Screening  (Timothy J. Shafer)....Pages 275-297
 Advances in Human Stem Cell-Derived Neuronal Cell Culturing and Analysis  (Laura Ylä-Outinen, Jarno M. A. Tanskanen, Fikret E. Kapucu, Anu Hyysalo, Jari A. K. Hyttinen, Susanna Narkilahti)....Pages 299-329
 Long-Term Activity Dynamics of Single Neurons and Networks  (Sebastian Reinartz)....Pages 331-350
 Closed-Loop Systems and In Vitro Neuronal Cultures: Overview and Applications  (Marta Bisio, Alexey Pimashkin, Stefano Buccelli, Jacopo Tessadori, Marianna Semprini, Timothée Levi et al.)....Pages 351-387