In Vitro Aspects of Erythropoiesis

Front Matter....Pages i-xix
Erythropoiesis In Vitro : A Brief Introduction....Pages 1-2
Erythropoietin-Independence of Early Erythropoiesis and a Two-Regulator Model of Proliferative Control in the Hemopoietic System....Pages 3-7
 In Vitro Modulation of Human Erythropoiesis by Lymphocyte-Rich Fractions of Blood....Pages 8-20
Cryogenic Preservation of Human and Murine Erythropoietic and Granulopoietic Colony-Forming Cells....Pages 21-27
Miniaturization of Methylcellulose Erythroid Colony Assay....Pages 28-30
Culture Systems In Vitro for the Assay of Erythrocytic and Megakaryocytic Progenitors....Pages 31-36
Discussion (Chapters 1–6)....Pages 37-43
Cellular and Soluble Factors Influencing the Differentiation of Primitive Erythroid Progenitor Cells (BFU-e) In Vitro ....Pages 44-57
The Effect of Sustained Hypertransfusion on Hematopoiesis....Pages 58-63
Inhibitors of Erythropoiesis: Effects of Red Cell Extracts on Heme Synthesis and Erythroid Colony Formation in Human Bone Marrow Cultures....Pages 64-67
Production of Erythroid Precursor Cells in Long-Term Cultures of Mouse Bone Marrow Cells....Pages 68-71
Production of Erythroid Precursor Cells (BFU) In Vitro ....Pages 72-74
Discussion (Chapters 7–11)....Pages 75-80
Hormonal Modulation of Erythropoiesis In Vitro ....Pages 81-85
Regulatory Mechanisms of Erythroid Stem Cell Kinetics....Pages 86-94
Hormonal Influences on Erythroid Colony Growth in Culture....Pages 95-99
A Lack of Burst-Forming Unit (BFU-e) and Lymphocyte-Mediated Suppression of Erythropoiesis in Patients with Aplastic Anemia....Pages 100-102
Pharmacological Agents and Erythroid Colony Formation: Effects of Beta-Adrenergic Agonists and Steroids....Pages 103-117
 In Vitro Assessment of Similarities between Erythroid Precursors of Fetal Sheep and Patients with Polycythemia Vera....Pages 118-122
Discussion (Chapters 12–17)....Pages 123-128
Murine Erythroleukemia: Cell Surface and Cell Cycle-Related Events in Induced Differentiation....Pages 129-134
Regulation of Heme Biosynthesis in Mouse Friend Virus-Transformed Cells in Culture....Pages 135-142
Comparative Studies on Hemopoietic Stem Cell Pools in Mice after Friend (FV-P) or Rauscher Virus Infection....Pages 143-148
Studies on Erythroid Differentiation in a Wild-Type and Dimethylsulfoxide-Resistant Clones of Friend Virus-Transformed Cells: Effects of Hemin, Hemoglobin, Erythropoietin....Pages 149-155
Induction of Uroporphyrinogen-I Synthase Activity in Mitogen-Stimulated Lymphocytes: Deficient Induction in Acute Intermittent Porphyria Cells....Pages 156-158
Potential for Differentiation, Virus Production, and Tumorigenicity in Murine Erythroleukemic Cells Treated with Interferon....Pages 159-171
Kinetics of Erythroid and Myeloid CFU Following Rauscher Virus Infection....Pages 172-176
Discussion (Chapters 18–24)....Pages 177-180
The Role of Serum Inhibitors of Erythroid Colony-Forming Cells in the Mechanism of the Anemia of Renal Insufficiency....Pages 181-188
Modulatory Effect of Macrophages on Erythropoiesis....Pages 189-191
Discussion (Chapters 25–26)....Pages 192-193
Extrarenal Erythropoietin....Pages 194-217
 In Vitro Aspects of Erythropoietin Production....Pages 218-224
Renal and Extrarenal Erythropoietin Production in Anemia....Pages 225-226
Recent Advances in Erythropoietin Physiology....Pages 227-239
Discussion (Chapters 27–30)....Pages 240-242
Back Matter....Pages 243-280