Immunology of Silicones

Front Matter....Pages I-XX
Front Matter....Pages 1-1
Silica, Silicon and Silicones...Unraveling the Mystery....Pages 3-12
Silicone Degradation Reactions....Pages 13-23
Chemical, Physical and Mechanical Analysis of Explanted Breast Implants....Pages 25-37
Silicon and Silicone Levels in Patients with Silicone Implants....Pages 39-48
Detection of Silicone Migration and Biodegradation with NMR....Pages 49-58
Serum Silicon Levels are Elevated in Women with Silicone Gel Implants....Pages 59-65
Front Matter....Pages 67-67
The Development of an ELISA Method for the Detection of “Antibodies” to Silicone....Pages 69-74
The Adsorption of Proteins on a Polydimethylsiloxane Elastomer (PEP) and Their Antigenic Behavior....Pages 75-84
Aspecific Immunoglobulin Binding to Hydrophobic Surfaces....Pages 85-91
Cytotoxicity and Membrane Damage in vitro by Inclusion Complexes Between γ-Cyclodextrin and Siloxanes....Pages 93-99
Front Matter....Pages 101-101
Induction of Type II Collagen Arthritis in the DA Rat Using Silicone Gel as Adjuvant....Pages 103-111
The Adjuvancy of Silicones: Dependency on Compartmentalization....Pages 113-121
The Adjuvant Effect of Silicone Gel and Silicone Elastomer Particles in Rats....Pages 123-137
Silicone Gel and Octamethylcyclotetrasiloxane Potentiate Antibody Production to Bovine Serum Albumin in Mice....Pages 139-144
Front Matter....Pages 145-145
Fibrogenic and Other Biological Effects of Silica....Pages 147-158
Macrophages in Host Defense Mechanisms....Pages 159-165
Structure and Function of Natural Antibodies....Pages 167-179
Antibodies to Cholesterol: Biological Implications of Antibodies to Lipids....Pages 181-186
Front Matter....Pages 187-187
Silicone-Induced T Cell Proliferation in Mice....Pages 189-198
Silicone-induced Modulation of Natural Killer Cell Activity....Pages 199-208
Front Matter....Pages 187-187
HLA Typing in Women With and Without Silicone Gel-filled Breast Implants....Pages 209-225
T Cell-Mediated Immune Response to Silica in Silicone Breast Implant Patients....Pages 227-236
Immunohistopathology and T Cell Receptor Gene Expression in Capsules Surrounding Silicone Breast Implants....Pages 237-242
Front Matter....Pages 243-243
Macrophage-Silicone Interactions in Women with Breast Prostheses....Pages 245-252
Microscopic Techniques and Histologic Findings in Silicone Mammary Implant Capsules and Regional Paranodal Tissues....Pages 253-261
Front Matter....Pages 263-263
Antinuclear Antibodies in Apparently Healthy Women with Breast Implants....Pages 265-268
Silicone Binding Immunoglobulins in Human Sera....Pages 269-276
Autoantibodies in Patients with Silicone Implants....Pages 277-282
Clinical and Laboratory Features of Patients with Scleroderma and Silicone Implants....Pages 283-290
Re-Evaluation of Autoantibodies and Clinical Overview of Silicone-Related Disorders....Pages 291-298
Development of Scleroderma-like Syndrome in Tsk/+ Mice Is Not Enhanced by Silicone Administration....Pages 299-306
Comparative Epitope Mapping of Antibodies to Collagen in Women with Silicone Breast Implants, Systemic Lupus Erythematosus and Rheumatoid Arthritis....Pages 307-316
The Prevalence of Autoantibodies in Symptomatic and Asymptomatic Patients with Breast Implants and Patients with Fibromyalgia....Pages 317-322
Monocyte/Macrophage Infiltrates in the Salivary Glands of Women with Silicone Breast Implants....Pages 323-326
Novel Anti-Silicone Surface-Associated Antigen Antibodies (Anti-SSAA(x)) May Help Differentiate Symptomatic Patients with Silicone Breast Implants from Patients with Classical Rheumatological Disease....Pages 327-336
Laboratory Studies in Breast Implant Patients: ANA Positivity, Gammaglobulin Levels, and Other Autoantibodies....Pages 337-353
Front Matter....Pages 355-355
Is the Risk of Multiple Myeloma Increased in Patients with Silicone Implants?....Pages 357-359
Multiple Myeloma in Women with Silicone Breast Implants. Serum Immunoglobulin and Interleukin-6 Studies in Women at Risk....Pages 361-366
Silicone Gel Implants and Monoclonal Gammopathies: Three Cases of Multiple Myeloma and the Prevalence of Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance....Pages 367-374
Monoclonal Gammopathy of Undetermined Significance....Pages 375-383
Front Matter....Pages 355-355
The National Cancer Institute Silicone Implant/Multiple Myeloma Registry....Pages 385-387
The Epidemiology of Monoclonal Gammopathy of Unknown Significance: A Review....Pages 389-395
Plasmacytoma Development in Mice Injected with Silicone Gels....Pages 397-407
Front Matter....Pages 409-409
The Association of Augmentation Mammoplasty with Connective Tissue Disease, Including Systematic Sclerosis (Scleroderma): A Meta-Analysis....Pages 411-417
The Prevalence of Breast Implants Among Women in the United States....Pages 419-425
Epidemiology of Autoimmune and Immunological Diseases in Association with Silicone Implants: Is There an Excess of Clinical Disease or Antibody Response in Population-based or Other “Controlled” Studies?....Pages 427-430
Back Matter....Pages 431-432