Immunological Approaches to Contraception and Promotion of Fertility

Front Matter....Pages i-x
Inaugural Remarks....Pages 1-2
Inaugural Remarks....Pages 3-4
Whence the Anti Hormones?....Pages 5-15
Immunological Approaches to Contraception: The Need, Basic Premise, and Overview....Pages 17-24
Lack of Toxicological Effects Following Seven Years of Active Immunization of Rhesus Monkeys with the β-Subunit of Ovine Luteinizing Hormone....Pages 25-33
Reaction of a Chimpanzee to Immunization with oLHβ....Pages 35-36
Improved Immunogenic Formulations for Antigonadotropin Response....Pages 37-41
A Fertility Regulating Vaccine Based on the Carboxyl-Terminal Peptide of the Beta Subunit of Human Chorionic Gonadotrophin....Pages 43-59
Enhancement of Antibody Response to an Antigonadotropin Vaccine by use of Adjuvants....Pages 61-70
Rational Vaccine Design: Opportunities Offered by Molecular Genetics....Pages 71-75
Cloning and Expression of Biologically Active Human Fertility Hormones....Pages 77-91
Cloning and Expression of Lutropin Genes....Pages 93-102
Development of oFSH as a Vaccine for the Male — A Status Report on the Recent Reasearches Carried Out Using the Bonnet Monkey (M. Radiata)....Pages 103-110
Immunization Against FSH as a Method of Male Contraception....Pages 111-113
Effects of Active Immunization with Follicle Stimulating Hormone (FSH) on Spermatogenesis in the Adult Crab Eating Monkey- Evaluation for Male Contraception....Pages 115-123
LHRH Immunoneutralization: Basic Studies and Prospects for Practical Application....Pages 125-141
Immunization Against LHRH Without the Use of Freund’s Complete Adjuvant....Pages 143-150
Sperm Antigens, Immunologic Infertility and Contraception....Pages 151-154
Transformation of the Nucleus During Mammalian Spermatogenesis and Fertilization: Implications for Contraceptive Development....Pages 155-174
Sperm Antigens Related to Infertility....Pages 175-181
Toward the Development of an Anti-Sperm Contraceptive Vaccine....Pages 183-190
Contraceptive Effect of Two Anti-Sperm Monoclonal Antibodies, Administered Singly and in Combination, in the Mouse....Pages 191-199
Monoclonal Antibodies Against Human Sperm....Pages 201-201
The Potential Effectiveness and Safety of Second Generation Vaccines....Pages 203-207
Factors Affecting the Generation and Contraceptive Effectiveness of Immune Responses to Sperm....Pages 209-217
Immunosuppression of Fertility by LDH-C 4 ....Pages 219-230
Characterization of an Antisperm Monoclonal Antibody Inducing Human Sperm Agglutination....Pages 231-240
Molecular Genetics of the Mouse Zona Pellucida: Implications for Fertilization and Early Development....Pages 241-249
Species Variation in the Zona Pellucida....Pages 251-268
Immunohistological Studies During Immunization of Primates with Porcine Zona Pellucida: Preliminary Observations....Pages 269-275
Antigenic Profile and Impact of Immunization with Zona Pellucida Antigens in Primates....Pages 277-290
Effect of Immunization of Primates Against Porcine Zonae on Fertility and Hormone Profiles....Pages 291-299
Prospects for Control of Fertility in the Female Dog by Active Immunization with Porcine Zona Pellucida Proteins....Pages 301-309
Anti-GnRH Monoclonals: Pituitary and Extrapituitary Actions in Control of Fertility....Pages 311-322
Purification of Human Gamete Antigens Relevant to Antibody Production: Application of Monoclonal Antibodies....Pages 323-333
Characteristics of Anti-Zona Monoclonal Antibodies....Pages 335-341
Aggressive and Protective Immunological Reactions of the Pregnant Mother to the Conceptus....Pages 343-349
Effects of Antibodies to Steroid Hormones on Reproductive Events of Sheep and Cattle....Pages 351-366
The Relationship of Egg Production in the Chicken to its Major Histocompatibility Complex....Pages 367-374
Bovine Embryo: Development, Cloning, Sexing and Transfer of Genes....Pages 375-392
Pregnancy Outcome in Human Couples with Idiopathic Recurrent Abortions: The Role(s) of Female Serum, Mixed Lymphocyte Culture Blocking Factors, Potentiating Factors, and Local Uterine Immunity Before and After Paternal Leukocyte Immunization....Pages 393-406
Immunostimulation and the Promotion of Fertility....Pages 407-415
Histocompatibility and Reproduction....Pages 417-423
Valediction Immunocontraception — From Romance to Reality....Pages 425-429
Back Matter....Pages 431-441