Immunohematology and Blood Banking II MD0846

DEVELOPMENT
ADMINISTRATION
TABLE OF CONTENTS
INTRODUCTION
LESSON 1
	Section I. THE IMMUNE RESPONSE AND THE INTERACTION OF ANTIGENS,ANTIBODIES, AND COMPLEMENT IN IMMUNOHEMATOLOGY
		1-1. BACKGROUND
		1-2. THE IMMUME RESPONSE
		1-3. ANTIGENS
		1-4. ANTIBODY SYNTHESIS
		1-5. PRIMARY AND SECONDARY IMMUNE RESPONSES
		1-6. IMMUNIZATION TO BLOOD-GROUP ANTIGENS
		1-7. ANTIBODY STRUCTURE, FUNCTION, AND PROPERTIES
		1-8. ANTIGEN-ANTIBODY REACTIONS IN BLOOD GROUP SEROLOGY
		1-9. AGGLUTINATION
		1-10. HEMOLYSIS
		1-11. COMPLEMENT
		1-12. THE CLASSIC COMPLEMENT PATHWAY
		1-13. THE ALTERNATIVE COMPLEMENT PATHWAY
		1-14. STABILITY OF COMPLEMENT WITH PARTICULAR REFERENCE TO THEDETECTION OF BLOOD-GROUP ANTIBODIES
	Section II. THE ANTIGLOBULIN TEST
		1-15. PRINCIPLES OF THE ANTIGLOBULIN TEST
		1-16. DIRECT ANTIGLOBULIN TEST
		1-17. INDIRECT ANT IGLOBULIN TEST
		1-18. ROLE OF COMPLEMENT IN THE ANTIGLOBULIN REACTION
		1-19. MECHANISMS FOR SENSITIZATION OF RED BLOOD CELLS BY COMPLEMENT
		1-20. STANDARDIZATION OF ANTIGLOBULIN SERUMS
		1-21. POLYSPECIFIC ANTIGLOBULIN REAGENTS
		1-22. MONOSPECIFIC ANTIGLOBULIN SERUMS
		1-23. FACTORS AFFECTING THE ANTIGLOBULIN TEST
		1-24. SOURCES OF ERROR
	Section III. RED BLOOD CELL ANTIBODIES
		1-25. ALLOANTIBODIES
		1-26. PROCEDURES
		1-27. READING AND INTERPRETATION OF REACTIONS
		1-28. REAGENT RED BLOOD CELLS
		1-29. SERUM
		1-30. CONTROLS
		1-31. ANTIBODY DETECTION
		1-32. ANTIBODY IDENTIFICATION
		1-33. USE OF RED BLOOD CELL PANELS
		1-34. ANTIGENIC FREQUENCY
		1-35. INTERPRETATION OF COMMON PANEL RESULTS
		1-36. ANTIBODIES NOT EASILY IDENTIFIED
		1-37. USEFUL ADDITIONAL NOTES
		1-38. COLD ANTIBODIES
		1-39. TITRATION
		1-40. ABSORPTION
		1-41. ELUTION
	Section IV. DETERMINATION OF COMPATIBILITY
		1-42. DETERMINATION OF COMPATIBILITY
		1-43. COLLECTION OF BLOOD FROM RECIPIENT
		1-44. PRETRANSFUSION TESTING OF THE RECIPIENT
		1-45. SELECTION OF BLOOD
		1-46. MASSIVE TRANSFUSION
		1-47. TECHNIQUES FOR CROSSMATCHING
		1-48. INCOMPATIBLE CROSSMATCH
		1-49. LABELING AND RELEASE OF CROSSMATCHED BLOOD
		1-50. RETENTION AND STORAGE OF BLOOD SAMPLES
		1-51. RELEASE OF BLOOD IN EMERGENCY SITUATIONS
		1-52. CROSSMATCH IN PRESENCE OF PROLONGED CLOTTING TI
		1-53. COMPATIBILITY TESTING AFTER INFUSION OF SYNTHETIC PLASMA EXPANDERS
	EXERCISES
	SOLUTIONS
LESSON 2
	Section I. INVESTIGATION OF A POSITIVE DIRECT ANTIGLOBULIN TESTAND IMMUNE HEMOLYTIC ANEMIA
		2-1. GENERAL
		2-2. IMMUNE HEMOLYTIC ANEMIA
		2-3. GENERAL SEROLOGIC INVESTIGATIONS
		2-4. SPECIFICITY OF AUTOANTIBODY
		2-5. COLD AGGLUTININ TITER. THERMAL AMPLITUDE, AND CONFIRMATIONOF ANTI-l(i) SPECIFICITY
		2-6. ABO AND Rh GROUPING
		2-7. AUTOIMMUNE HEMOLYTIC ANEMIA ASSOCIATED WITH WARM ANTIBODIES
		2-8. AUTOIMMUNE HEMOLYTIC ANEMIA ASSOCIATED WITH COLD ANTIBODIES
		2-9. DRUG-INDUCED "IN VIVO" RED BLOOD CELL SENSITIZATION
		2-10. LABORATORY INVESTIGATION OP DRUG-RELATED PROBLEMS
		2-11. DETECTION OF ANTIBODIES TO PENICILLIN AND CEPHALOTHIN
	Section II. HEMOLYTIC DISEASE OF THE NEWBORN
		2-12. BACKGROUND
		2-13. CLASSIFICATION
		2-14. MECHANISMS OF MATERNAL IMMUNIZATION
		2-15. TRANSFER OF ANTIBODY TO THE FETUS
		2-16. CLINICAL AND LABORATORY FEATURES OF HEMOLYTIC DISEASE
		2-17. PRENATAL STUDIES
		2-18. LABORATORY INVESTIGATION OF HEMOLYTIC DISEASE OF NEWBORNS DURING THE NEONATAL PERIOD
		2-19. TREATMENT OF HEMOLYTIC DISEASE OF THE NEWBORN
		2-20. RhO(D) IMMUNE GLOBULIN (HUMAN)-RhIG
		2-21. MASSIVE FETOMATERNAL HEMORRHAGE
		2-22. MATERNAL ALLOIMMUNIZATION TO PLATELETS, NEUTROPHILS, AND PROTEIN ALL O TYPES
		EXERCISES
		SOLUTIONS
LESSON 3
	Section I. BLOOD TRANSFUSION PRACTICE
		3-1. BACKGROUND
		3-2. TRANSFUSION OF BLOOD PRODUCTS CONTAINING RED BLOOD CELLS
		3-3. TRANSFUSION OF PLATELETS
		3-4. BLOOD PRODUCTS USED TO REPLACE PLASMA COAGULATION FACTORS
		3-5. PLASMA SUBSTITUTES
		3-6. SPECIAL SITUATIONS INVOLVING TRANSFUSION
		3-7. ADMINISTRATION OF BLOOD PRODUCTS
	Section II. ADVERSE EFFECTS OF BLOOD TRANSFUSION
		3-8. BACKGROUND
		3-9. IMMEDIATE EFFECTS
		3-10. DELAYED EFFECTS
		3-11. RECORDS OF TRANSFUSION COMPLICATIONS
	Section III. PREVENTION OF HEPATITIS
		3-12. BACKGROUND
		3-13. SELECTION OF DONORS
		3-14. TESTING FOR HEPATITIS B SURFACE ANTIGEN AND HEPATITIS C IN BLOOD
		3-15. RECIPIENT FOLLOW-UP FOR POST-TRANSFUSION HEPATITIS
		3-16. HEPATITIS-IMPLICATED DONORS AND THOSE FOUND TO HAVE HEPATITIS B SURFACE ANTIGEN OR HEPATITIS C VIRUS
		3-17. USE OF GAMMA GLOBULIN WITH TRANSFUSIONS
		3-18. LABORATORY SAFETY
		EXERCISES
		SOLUTIONS
APPENDIX
	BIBLIOGRAPHY