Immunobiology of HLA: Volume II: Immunogenetics and Histocompatibility

Front Matter....Pages i-lv
Front Matter....Pages lvii-lvii
HLA 1987....Pages 1-9
HLA-A,B,C: Patterns of Polymorphism in Peptide-Binding Proteins....Pages 10-33
HLA Class I Gene Family: Characterization of Genes Encoding Non-HLA-A,B,C Proteins....Pages 33-40
Molecular Structure of Human Class II Antigens....Pages 40-49
Regulation of HLA Class II Gene Expression....Pages 49-62
Molecular Genetics of the Class III Region of the HLA Complex....Pages 62-69
Front Matter....Pages N1-N1
Mapping of the Human Major Histocompatibility Complex by Pulsed Field Gel Electrophoresis....Pages 73-75
Towards a Physical Map of the HLA Complex....Pages 75-78
Organization of the HLA Class I Region....Pages 79-82
Mapping of HLA Class II Genes by Pulsed Field Gel Electrophoresis and Size Polymorphism....Pages 83-86
The Tumor Necrosis Factor (TNFA) and Lymphotoxin (TNFB) Genes Map Between the HLA Class III and Class I Regions....Pages 86-87
A Human t-Complex-Related Gene (TCP1) Is Not Closely Linked to the HLA Complex....Pages 87-89
Molecular Characterization of Serologic Recognition Sites in the HLA-A2 Molecule Using Oligonucleotide-Generated Site-Specific Mutants....Pages 93-97
Molecular Characterization of Allospecific Cytotoxic T-Lymphocyte Recognition Sites in the HLA-A2 Molecule Using Oligonucleotide-Generated Site-Specific Mutants....Pages 97-100
Mapping of Serologic and CTL-Defined Epitopes on HLA-A2 by Site-Directed Mutagenesis....Pages 101-103
Cytotoxic T Cell and Antibody Recognition of HLA-A2,A28 Molecules Analyzed by Site Directed Mutagenesis....Pages 103-104
Peptides Derived From HLA-A2 Modulate Lysis by HLA-A2-Specific Cytotoxic T Lymphocytes....Pages 105-107
Variant and Mutant HLA-A2 Molecules Affect Recognition of Influenza Matrix Peptide 56–68 by Cytotoxic T Lymphocytes....Pages 107-110
Class I-Presented Influenza Peptides Predicted by an Algorithm that Selects Class II-Presented Peptides....Pages 110-111
Structure of HLA-B27 Subtypes: Evolutionary Implications....Pages 111-112
Front Matter....Pages N1-N1
Cellular Allorecognition of HLA-B27: Clonal Heterogeneity and Identification of Immunodominant Sites....Pages 112-113
Molecular Analysis of the Variant Alloantigen HLA-B27d Identifies a Unique Single Amino Acid Substitution....Pages 113-114
CTL Recognize Certain Bacterial Antigens in Association with HLA-B27....Pages 115-117
HLA-Bw62 Variants Identified by a Cytotoxic T Lymphocyte Clone and Isoelectric Focusing Gel Electrophoresis....Pages 117-119
Comparison of the Amino Acid Sequences Encoded by the HLA-Bw47 and HLA-B13 Genes....Pages 120-122
Cloning and Analysis of the cDNA Encoding New HLA C Antigen Cx52....Pages 122-123
A C Locus-Related HLA Class I Molecule on Human Trophoblast....Pages 124-125
How Similar Are Chimpanzee and Human Class I Antigens?....Pages 126-126
Serological and Biochemical Studies of an HLA-A Locus Public Epitope....Pages 127-127
Characteristics of HLA Class I Antigens in Human Sera....Pages 128-128
The H-2K kml Mutation: A Single Nucleotide Substitution Causes Multiple Functional Differences in a Murine Class I MHC Molecule....Pages 129-130
Molecular Mapping of Antigenic and Cytotoxic T Lymphocyte Recognition Determinants on the Major Histocompatibility Complex Class I Molecule Kb Using In Vitro Mutant Cell Lines....Pages 130-131
Isolation of an HLA-A:,B:,C Null Human Cell Line Capable of Expressing Transferred Class I Genes....Pages 135-136
Selective Increase of Expression of HLA Class I Molecules by HLA-A3, HLA-B7, and HLA-Cw3 Transfected P815 Mastocytoma Cells After Subsequent Transfection by the Human β2-Microglobulin Gene....Pages 136-138
The Cloning, Exon Shuffling, and Expression of the HLA-Cw1 Gene....Pages 138-140
Weak Stimulation of Murine Cytotoxic T Cells by Human Class I Molecules Maps to the αl + α2 Domains....Pages 140-142
Phorbol Ester (PMA)-Activated Protein Kinase C Phosphorylates the Class I HLA Heavy Chain....Pages 145-147
Differential Modulation by Anti-HLA Class I Monoclonal Antibodies of T Cell Proliferation Induced via CD2 and CD3 Pathways....Pages 147-150
Anti-HLA Class I Antibodies Alter Gene Expression in Human Natural Killer Cells....Pages 150-152
Adenovirus Inversely Modulates Target Cell Class I Antigen Expression and Sensitivity to Natural Killing....Pages 152-155
Front Matter....Pages N1-N1
Differential Regulation of HLA B Antigen Expression by Interferon....Pages 155-156
Transfer and Expression of Human Non-A,B,C Class I Genes in Human HLA A,B,C Null Lymphoblastoid Cells....Pages 159-161
Activated T Cells Express a Non-HLA-ABC Class I Gene that Is Inducible with Gamma-Interferon....Pages 161-163
A Novel Class I HLA Gene....Pages 163-166
Isolation from the Human MHC of a Class I Gene Encoding a Nonubiquitous Antigen Expressed on Activated Cells....Pages 166-170
Cellular Distribution and Expression Regulation of HA Molecules (New Class I-Like Antigens)....Pages 170-173
A Human T Cell Clone Recognizes a Qa- or Tla-Like Antigen in Man....Pages 174-174
Comparative Analysis of TL b and TL c Gene Organization....Pages 175-177
Study of an Endogenous Retrovirus-Like Locus Reveals Genetic Polymorphisms Related to Mouse TLA Haplotypes....Pages 177-178
Analysis of Isotypic and Allotypic Sequence Variation in the HLA-DRβ Region Using the In Vitro Enzymatic Amplification of Specific DNA Segments....Pages 181-185
Two Different T-Cell Perspectives on the DR1 Alloantigen....Pages 185-187
Polymorphism of the DR1 Haplotype: Structural and Functional Analysis....Pages 187-189
The Heterogeneity of HLA-DR2....Pages 190-190
Correlation of Primary Sequence and Functional Determinants of HLA Class II Molecules....Pages 191-194
Molecular Studies of a Rare HLA Haplotype: Implications for Mechanisms of Generating Class II Gene Polymorphisms....Pages 194-197
Identification of Dw2, Dw12, and “Short” DR2 Splits with Sequential Exon-Specific DRβ, DQβ, and DQα cDNA Probes....Pages 198-198
Subdivision of Haplotype HLA-DR3 by Biochemical and Functional Analysis....Pages 199-199
Characterization of Multiple HLA-DR3 Haplotypes....Pages 200-201
DR3 Heterogeneity in American Blacks....Pages 202-203
Correlation Between Function and Expression of the Two DR Molecules in DR3 Haplotypes....Pages 204-206
Front Matter....Pages N1-N1
Single Amino Acid Substitutions Within the HLA DR4β 1 Chain Create Multiple T-Cell Recognition Sites....Pages 207-210
DR4 Recognized by PLT Clones....Pages 210-211
A Novel DR5 B1 (DRw11) Chain with a Distinctive Third Diversity Region....Pages 212-214
Restriction Fragment Length Polymorphism in Serologically Defined DR5: The Difference Between DRwll and DRw12....Pages 214-215
HLA-DRw6 and Its Complexity....Pages 216-217
DRw6 Polymorphism in American Blacks....Pages 217-218
Molecular Diversity of HLA-DRw6 Haplotypes....Pages 218-219
Sequence Analysis of the DRw13 β Chain Genes:: The Dw19 Specificity May Be Encoded by the DRB3 Locus....Pages 220-222
DR and DQ a and ß Polymorphism in DRw13- and DRw52 +-Related Haplotypes....Pages 222-223
Structural Mapping of T Cell Clones Restriction Elements Suggests That a DQα-DRβ Hybrid Molecule Could Be Functional in DRw13 Cells....Pages 223-225
Restriction Fragment Length Polymorphism of HLA-DR7 Alleles and Association with HLA-B Antigens....Pages 225-226
Two-Dimensional IEF Analysis of DR, DQ, and DP Molecules from DRW8-Carrying Haplotypes....Pages 226-227
Identification of a Cellularly Defined DRW8 Subtype....Pages 227-228
Molecular Polymorphism of HLA-DRw8....Pages 229-230
Biochemical Studies of the DRw9 Specificity in Caucasians....Pages 231-232
Molecular Definition of the DRW10 Haplotype....Pages 232-234
Cloning and Sequence Analysis of the DRβ Gene Coding for the Specificity HLA D/DR BON....Pages 235-236
Structure of HLA-D/DR-BON Antigen....Pages 236-237
Biochemical Analysis of HLA Class II Antigens Using Transfected Cells....Pages 238-239
Quantitation of Component Molecules of Precipitated Class II Complexes....Pages 240-241
Front Matter....Pages N1-N1
Epitope Mapping of HLA-DR Antigens with the Use of DNA-Transfected Cells....Pages 245-247
Monoclonal Antibody Definition of Polymorphism Within DRw52....Pages 247-248
Oligonucleotide Typing Analysis of the Polymorphism of DRB1 and DRB3 Genes Within DRw52 Haplotypes....Pages 248-250
Subtypes of DRw52: Different Typing Techniques Reveal Very Similar but Distinct Typing Results....Pages 251-252
Variants of HLA-DRw52 Defined by Proliferative T-Lymphocyte Clones....Pages 253-255
Functional and Structural Analysis of HLA-DRw52....Pages 255-258
Immunochemical Assessment of DRw52 Specificity by the Use of HLA Class II Transfectant Molecules....Pages 258-260
Three Subtypes of DRw52 Molecules Among DR3, DR5, and DRw6 Haplotypes....Pages 260-261
Three Functionally Distinct DRw52 Subtypes Are Alleles of the DRβIII Locus....Pages 261-262
The Allelic Determinants HLA-DR3 and HLA-DR5 and the Supertypic Determinant HLA-DRw52 May Be Located on the Same DRβ Chain....Pages 263-263
An Abnormal DRB4 (DRw53) mRNA Is Produced by DR7 Individuals Who Fail to Express the Gene Product....Pages 264-266
Evidence for a Hot Spot for Generalized Gene Conversion in the Second Exon of MHC Genes....Pages 266-269
DRα-DQβ: A Novel Class II Molecule Whose Expression is Influenced by the Ratio of α β Chains Transcripts....Pages 273-275
Biochemical Analysis of DQ α Polymorphisms Defined by a Monoclonal Antibody....Pages 275-277
At Least Three Allelic Forms of the α- and β-chain Genes Encode DQw1-Positive Molecules....Pages 277-278
Definition of Polymorphism Within DR2-Associated DQw1 Molecules....Pages 278-279
Division of HLA.DQw1 by DNA Typing and by an Alloserum: DR1, Subtypes of DR2 and DRw6; DRw10 and Rare Haplotypes DRw8-DQw1, DRw11-DQw1 Fit in Two Different Clusters....Pages 279-280
The DQβ Chain Dictates DQ Type for DQw2 and DQw3....Pages 280-281
Different DQw2 Are Associated with DR3 and DR7 as Revealed by RFLP Analysis....Pages 282-283
Evolution of DQw2-Related Haplotypes....Pages 283-285
Front Matter....Pages N1-N1
Subunit and Spatial Relationships of HLA-DQ Polymorphisms That Subdivide the DQw3 Specificity....Pages 286-287
Serology and RFLP Analysis of the Splits of DQw3....Pages 287-288
The HLA B17,BfS,C4A6,B1,DR7 and DQw3.2 Supratype Marks an Extensive Chromosomal Segment Shared Between Different Ethnic Group....Pages 288-289
Epitopes on HLA-DQw3 Molecules Recognized by T-Lymphocyte Clones....Pages 289-293
DQw3 Subtypes Linked to DRw9 Specificity: Biochemistry and RFLP Definition....Pages 293-294
A New DR Antigen, Associated with DQw7, Defined Serologically and by Restriction Fragment Length Polymorphism....Pages 295-296
Biochemical and Genomic Characterization of HLA-DQ Gene Products Associated with DR3, DR4, and DR5 Haplotypes....Pages 296-297
Cellular Analyses of DQ Antigens....Pages 297-298
DQw4: A New Allele of HLA-DQ....Pages 298-299
Comparative Analysis of the Two-Dimensional Gel Profiles of the Monoclonal Antibodies Tu22, IA3, and SPV-L3....Pages 299-300
Evidence for Intra HLA-DR and -DQ Subregion Crossing Over Events....Pages 301-301
Some Supratypes Extend to DQ....Pages 302-302
HLA Class II Restriction Fragment Length Polymorphism (RFLP) with Regard to the Class II Antigens....Pages 303-304
Class II RFLP Analysis Using β Domain Specific Probes....Pages 307-308
DNA Polymorphism of HLA-DP: Further Studies of the Restriction Fragment Length Polymorphism of DPα and DPβ....Pages 308-311
HLA-DP Region Complexity by CDC, RFLP, and Cellular Assays....Pages 311-314
Biochemical Polymorphism of the DPα and DPβ Chains....Pages 315-317
Proliferative Response by Stimulation of DP-Transfectants....Pages 317-320
Analysis of HLA-DP Allelic Sequence Polymorphism Using the In Vitro Enzymatic Amplification of DPα and DPβ Loci....Pages 321-322
Molecular Analysis of HLA-DP: DP β Chain Charge Heterogeneity Correlates with PLT Subtyping....Pages 322-322
Front Matter....Pages N1-N1
Sequence of a DPβ cDNA from the DR5, DQw7, DPw4b Cell Line Swei....Pages 323-324
T Cell Clones Show Polymorphism Within DPw1, DPw2, and DPw3 Specificities....Pages 324-325
HLA-DNA May Encode Two Unique Protein Products....Pages 329-329
A Novel HLA-Class II Molecule Distinct from HLA-DP/DQ/DR....Pages 329-332
Comparative Tissue Reactivity of the Monoclonal Antibody TU39 Which Detects HLA-Class II Molecules Including a Novel Determinant Designated DY....Pages 332-333
Human Anti-HLA Monoclonal Antibodies....Pages 337-338
A Human Monoclonal Antibody Binds to a Subset of HLA-DR Molecules on DR2/DQW1 Cell Line Cells....Pages 338-339
Five Human IgG Monoclonal Antibodies Obtained from a Single Polytransfused Patient Specific for Different Class I and Class II Major Histocompatibility Antigens....Pages 339-340
Cloning of a cDNA Encoding Class II Specific DNA Binding Protein....Pages 343-344
Regulation of HLA Class II Genes: Identification of a Regulatory Promoter Binding Protein Missing in Class II-Deficient Congenital Immunodeficiency....Pages 345-347
Bare Lymphocyte Syndrome Transcriptional Regulation of HLA Class II Expression....Pages 347-348
DX and DQ Promoter Regions Contain Homologous Sequences That Differ in Extent of Methylation....Pages 349-350
Activated Ras Oncogenes Partially Complement the Transcriptional Defects in Class II-Negative Mutant B-Cell Lines....Pages 350-351
Modulation of HLA Class II Expression Following Infection by HIV....Pages 352-354
Differential Modulation by Cytokines of the Gene Products of the HLA-D Region in Melanoma Cells with Different Metastatic Potential....Pages 354-356
Lymphotoxin and Class II HLA-DR Co-Precipitate?....Pages 356-358
Expression of HLA D Subregion Genes in Thyroid Follicular Cells Transfected with SV-40 + ....Pages 358-360
Structures of Class II MHC Molecules and Accessory Proteins During Trafficking in Subcellular Compartments....Pages 360-361
Class II MHC Complexes with I i , p70, and p80 (CS-It)....Pages 361-362
Intracellular Signaling Molecules Responsible for the Regulation of HLA Class II Antigen Expression....Pages 362-363
Front Matter....Pages N1-N1
HLA Class I and Class II Molecules Expressed in Monocytes, B Cells, and EBV Transformed Cells are Differentially Glycosylated....Pages 364-364
Functional Analysis of HLA-DR3: A Mutational Approach....Pages 367-369
Studies of MHC Class II Restricted Antigen Recognition by Human T Cell Clones Using Transfectant Antigen-Presenting Cells (APC)....Pages 369-372
Hybrid Human-Mouse Class II Molecules:: Localization of Antibody Binding Sites....Pages 373-375
Antigen Mimicry Cytotoxic T Cells Specific for Epstein-Barr Virus Recognize HLA Alloantigens....Pages 376-378
Effect of Human Immunodeficiency Virus on Dendritic Cells Isolated from Human Peripheral Blood....Pages 378-380
Alloreactive T4-Cell Clones Recognizing HLA Class II Antigen in Linkage Disequilibrium with HLA-Al....Pages 380-381
An Alloreactive Clone that Recognizes an Epitope Only on Monocytes....Pages 381-382
HLA Class II Positive T Cell Lines Lack Stimulatory Capability in the Mixed Leucocyte Reaction....Pages 382-383
Analysis of Defective Class II Allostimulation by γ-Interferon-Activated Fibroblasts....Pages 383-386
Pretreatment of Stimulator/Target Cells with Xyloside Inhibits Synthesis of the Class II Associated Proteoglycan, but Potentiates an MLR and Antigen Presentation....Pages 386-387
Roles of Accessory Molecules in Processing and Presentation of Foreign Antigens....Pages 387-389
Attempts to Understand the Effects of Anti-Class II Monoclonal Antibodies on Responder T Cells....Pages 389-392
Inhibition by Anti-HLA Class II Monoclonal Antibodies of OKT3-Induced T Cell Proliferation: Analysis of the Mechanism....Pages 392-393
Change in the Fine Specificity of a Human Cytotoxic T Cell Clone Under α-Interferon Treatment....Pages 394-396
Allelic Sequence Variation in the HLA-DQ Region: Implications for Localization of Serological Specificities and for Susceptibility to Autoimmune Disease....Pages 399-401
The HLA-DQB1 Gene Contributes to the Genetic Susceptibility to Insulin-Dependent Diabetes Mellitus....Pages 402-403
HLA-DR4-Associated Disease: Oligonucleotide Probes Identify Specific Class II Susceptibility Genes in Type I Diabetes and Rheumatoid Arthritis....Pages 404-406
Transfer and Expression of an IDDM Susceptibility Gene into Lymphoblastoid Cell Lines by Retroviral Vectors....Pages 406-408
DPA Polymorphisms in Normals, Type I Diabetics, and Patients with Graves’ Disease....Pages 409-410
Front Matter....Pages N1-N1
Restriction Fragment Length Polymorphism (RFLP) Defines a Graves’ Disease Associated DR3 Subtype: Involvement of the DR-DQ Subregion....Pages 410-410
Polymorphisms of the Human T-Cell Receptor α and β Chain Genes and Their Relationship to Insulin Dependent Diabetes Mellitus....Pages 411-412
HLA Haplotype Analysis in Danish HLA-DR3,4-Positive Insulin-Dependent Diabetics and Controls....Pages 413-414
DR4 Associated DQw3 Subdivision in Insulin-Dependent Diabetes with Polyendocrinopathies: Serology and RFLP....Pages 414-415
Polymorphism of HLA-DR4 Associated Gene Products in Rheumatoid Arthritis....Pages 415-417
New HLA DNA Polymorphisms Associated with Rheumatoid Arthritis....Pages 417-418
DR4 and DR1 Define Different Subsets of Patients with Rheumatoid Arthritis....Pages 418-419
Familial Rheumatoid Arthritis: Genetic Epidemiology of 75 White Multicase Families....Pages 419-420
An HLA DRw52 Split Defined by Restriction Fragment Length Polymorphism: Population Genetics in Normals and in an HLA DRw52 Associated Autoimmune Disease....Pages 420-422
Seropositive Rheumatoid Arthritis Is Associated with T-Cell Epitopes Encoded Within the Third Hypervariable Region of the HLA-DR1 and the HLA-DR4 Haplotype....Pages 422-425
In Vivo Expression of a Soluble Form of HLA Class I Antigens in Rheumatoid Synovial Cells....Pages 425-426
Characterization of HLA-DR β and HLA DQ β Alleles Associated with Pemphigus Vulgaris....Pages 426-428
HLA Class II Allelic Variation and Susceptibility to Pemphigus Vulgaris....Pages 429-432
DRβ Chain Polymorphism in Pemphigus Vulgaris....Pages 432-433
Immune Responses of Patients with Myasthenia Gravis to Peptides Representing Different Regions of the Human Acetylcholine Receptor....Pages 434-436
HLA Antigens in Japanese Patients with Childhood-Onset Myasthenia Gravis....Pages 436-437
Association Between Myasthenia Gravis and HLA Bw46, BfS, C4A4, C4B2, DRw9 in Chinese....Pages 437-438
HLA Antigens in 206 Japanese Patients with Narcolepsy and 46 Patients with Essential Hypersomnia....Pages 438-440
DR2 and DQw1 Molecules in Narcolepsy....Pages 440-443
DNA Polymorphism in Multiple Sclerosis, Correlations with Susceptibility and Resistance to the Disease....Pages 444-445
Front Matter....Pages N1-N1
Chronic Progressive Multiple Sclerosis Is Associated with a Specific HLA-DQB Restriction Fragment Pattern....Pages 445-445
Polymorphic Restriction Fragments Detected with HLA-DQα Discriminate Between DR2-Positive Multiple Sclerosis Patients and Healthy Controls....Pages 446-446
HLA Class III Complement Genes and Susceptibility to Systemic Lupus Erythematosus (SLE)....Pages 447-447
Autoantibodies to Procollagen Type VII in EBA and Bullous Eruption of SLE Are HLA-DR2 Associated....Pages 448-448
Absence of Polymorphism between DR and DQ Sequences Isolated from Celiac Disease Patients and Normals....Pages 448-449
HLA-DP Region Is Relevant to Celiac Disease Susceptibility....Pages 449-450
The Role of Lymphotoxin in the Pathogenesis of Celiac Disease....Pages 450-451
Monomorphic HLA Reactivity in Heroin Addicts and Hydatidosis Patients....Pages 452-452
HLA Studies in Southern Chinese Suggest Hypotheses for Associations with Autoimmune Disease....Pages 452-454
MHC Gene Arrangements on Disease Associated Supratypes Revealed by Pulsed Field Gel Electrophoresis....Pages 454-455
Polymorphism of the HLA-Linked Steroid 21-Hydroxylase Genes....Pages 455-457
HLA, Complotypes, and RFLP Analysis of 21-Hydroxylase (21-OH) and C4 Genes in Finnish Families with a 21-OH Deficient Patient....Pages 458-458
Selection by Typhoid and Yellow Fever Epidemics Witnessed by the HLA-DR Locus....Pages 461-462
HLA-DR Molecules Are Both Ir-and Is-Gene Products for T Cell Responsiveness Against M. Leprae....Pages 463-464
B35 and CW4 Are Risk Factors for Development of AIDS....Pages 465-465
HLA and Tuberculosis in Chinese Patients....Pages 466-467
AKR (H-2k) Leukemias Express H-2Dd-Like Molecules....Pages 471-471
MHC Class I Antigen Expression on Human Tumors....Pages 472-472
Study of Class I HLA Genes in Human Tumors....Pages 473-473
Poor Prognosis in Childhood Acute Lymphoblastic Leukemia (ALL) Is Associated with HLA-A11....Pages 474-475
Front Matter....Pages N1-N1
The Functional Heterogeneity of HLA Class II Determinants....Pages 475-476
Patterns of MHC Class II Molecules and mRNA Expression in Acute Myelogenous Leukemias....Pages 477-478
SIB-Pair Analyses in the Assessment of MHC Involvement in Germ Cell Tumor Pathogenesis....Pages 478-480
Induction of Specific Immunosuppression in the Mouse Using Cells of Recipient Origin Transfected with Genes from the Organ Donor....Pages 483-485
Donor T Cells Are Responsible for the Blood Transfusion Effect Across an H-2 Class I Disparity....Pages 486-486
T Cells Marked by the 2H4 Antigen Function in Allosuppression....Pages 487-487
Human Non-MHC-Restricted Immunosuppression by Alloantigen and IL2-Activated Cells....Pages 488-488
A Human Lymphoblastoid Cell Line Secreting Antiidiotypic Antibodies....Pages 489-491
Inhibitory Effects of FK506 in Combination with Cyclosporine A on Human Lymphocyte Alloproliferative Responses....Pages 491-493
Allogeneic Rat T-Suppressor Inducer Cells with In Vivo and In Vitro Activity....Pages 493-494
Differential Effects of Helper and Cytotoxic T-Lymphocyte Clones on Macrophage Function....Pages 495-496
Alloreactivity Studies of Lymphocytes in Bronchoalveolar Lavages from Canine Lung Allografts....Pages 497-499
Selective Detection of In Vivo-Activated:, Cytotoxic T Lymphocytes by Limiting Dilution Analysis: Murine CTL Distribution After Allosensitization with Sponge Matrix Allografts....Pages 499-501
Alloreactive Lymphocyte Adherence to Human Arterial Endothelial Cell Monolayers....Pages 501-504
In Vitro Lymphocyte Priming, Clonal Selection, and Response to Third-Party Lymphocytes by VG01 + and VG01 − T Cell Fractions....Pages 504-505
Association of Allograft Rejection and Inducible Interleukin-2 Receptor Expression on CD8 Lymphocytes....Pages 505-506
An In Vitro Model to Investigate the Importance for Renal Transplant Survival of Mismatches for Specific Histocompatibility Antigens....Pages 507-508
Characterization of γ:δ T-Cell Receptor Expressed on Peripheral Blood Lymphocytes After Allogeneic Bone Marrow Transplantation....Pages 508-510
TCA and MLCs in Bone Marrow Transplant Patients....Pages 510-511
Marrow Transplantation from Unrelated HLA-A,B,DR-Matched Volunteer Donors....Pages 515-516
Front Matter....Pages N1-N1
Risk Factors for Graft Rejection of Marrow Transplants From HLA Haploidentical Donors....Pages 516-517
HLA-DP and Acute Graft Versus Host Disease....Pages 517-519
Frequent GvHR-Like Syndromes Following Syngeneic Bone Marrow Transplantation Suggest Inappropriately Controlled Autoreactivity....Pages 519-520
Use of Synthetic Oligonucleotides for the Study of Hypervariable Regions of Human DNA and Their Clinical Applications....Pages 520-521
A DRw13-Specific DR Antigen Structure Implicated in Poor Kidney Graft Survival....Pages 521-524
DNA Typing of HLA Class II Antigens in Kidney Transplantation....Pages 524-525
Donor Selection for Highly Immunized Patients Based on Acceptable HLA-A and -B Mismatches....Pages 525-526
Influence of HLA Matching in Cardiac Allograft Recipients Receiving Cyclosporin A and Azathioprine....Pages 526-527
HLA Antigen Expression in Cardiac Transplant Biopsies: Association with Rejection and Propagation of Infiltrating Alloreactive Lymphocytes....Pages 527-529
Alloreactive Lymphocyte Propagation from Endomyocardial Biopsies from Heart Transplant Patients on Different Prophylactic Immunosuppressive Treatment Protocols....Pages 530-531
Autolymphocytotoxins in Cardiac Transplantation: Serology, Significance, and Association with HLA-A1 and HLA-A3....Pages 532-533
Role of HLA Class II-Specific Alloreactive T Cells in Biliary Epithelium Injury Associated with Liver Transplant Rejection....Pages 533-535
Cultured Epidermis as Long-Term Allografts Without Anti-HLA Sensitization....Pages 535-536
The Effect of Tumor Necrosis Factor (TNF) on (NZB × NZW)F 1 Lupus Nephritis....Pages 539-541
Treatment of EAE by Anti-MHC Class II-Specific Monoclonal Antibodies in Rhesus Monkeys....Pages 541-543
In Vitro Differentiation of a Human Thymic Clone Coexpressing CD4 and CD8 Molecules....Pages 547-549
Functional Characterization of T-cell Clones Using Related T-Cell Receptor V Gene Segments....Pages 550-551
TCR γ Chain Expression on Human Peripheral Blood T Lymphocytes....Pages 551-553
Molecular and Functional Characterization of Human T-Cell Clones Expressing TCR-γδ Antigen Receptor....Pages 554-554
A Novel Polyclonal T-Cell Receptor Expression Defect Probably Not Linked to HLA....Pages 555-556
Front Matter....Pages N1-N1
CDw29 Molecules from the Monocyte Surface Are Required for CD3-Induced T Cell Activation....Pages 556-559
Differential Effects of an Anti-IL-2 Receptor Antibody on Cytotoxic and Suppressor Cells....Pages 559-560
Coordinate-Enhanced Expression of Three Adhesion Molecules (LFA-3, CD2, and LFA-1) and Three Other Molecules (4B4, UCHL1, and Pgp-1) Defines a Human T Cell Subset Containing Memory Cells and Characterized by Enhanced γ Interferon Production....Pages 560-562
VG01 T Cell Activation Antigen Selects for Antigen Reactive Cells....Pages 563-564
Identification of Autoreactive Human Bone Marrow and Peripheral Blood CD3−, CD4−, CD8−Prothymocytes....Pages 564-566
A Novel Lymphokine Is Required for the Regulation of Autoaggressive Responses....Pages 566-568
Immunoregulatory Circuits Initiated by Autoreactive T Cell Clones: I. Generation of T Helper, T Amplifier, and T Suppressor Clones....Pages 569-571
Down-Regulatory Role of CD8 Molecules in CD2 MAb and CD3 MAb Induced Nonspecific Cytotoxicity of Cytotoxic T Lymphocyte Clones....Pages 571-572
Inhibitors of Cytotoxic T Lymphocyte Galactosyltransferase Inhibit Cytotoxic T Lymphocyte Interaction with Their Target Cells....Pages 572-573
Molecular Cloning of an Inducible Cytotoxic T-Lymphocyte-Associated Gene (Hu-CTLA 1) and Gene Localization to Human Chromosome 14....Pages 574-577
A Cluster of Antibodies (RR1/1, LB-2 and 84H10) That Inhibit LFA 1-Dependent Lymphoid and Myeloid Cell Adhesion Bind Intercellular Adhesion Molecule-1 (ICAM-1)....Pages 577-580
Intrathymic Injection of Fetal and Adult CD4 − 8 − Thymocytes: Analysis of Thymic and Peripheral Progeny....Pages 581-581
Molecular Characterization of Endothelial Monocyte Antigens....Pages 585-587
Stimulation of Growth and Differentiation of EBV Transformed Cell Lines by Use of Monoclonal Antibodies to New Differentiation Antigens....Pages 587-588
Characterization of a Human B-Lymphocyte Antigen Associated with the Receptor for BCGF-12 kD....Pages 588-591
Evolutionary Analysis of MHC Genes in Nonhuman Primates....Pages 595-595
The Detection of Feline Class I and Class II MHC Homologue Molecules and Genes by Biochemical and Molecular Genetic Techniques....Pages 596-597
New Strategies for the Production of Monoclonal Antibodies Against MHC-Encoded Antigens....Pages 601-601
HLA Typing Using Soluble Antigens from Serum or Plasma....Pages 602-602
Back Matter....Pages 603-617