Immunobiology and Immunopharmacology of Bacterial Endotoxins

Front Matter....Pages i-x
Front Matter....Pages 1-1
The Biology and Physiopharmacology Of Bacterial Lipopolysaccharide Endotoxins And Their Role In Immunoregulation - An Introductory Preview....Pages 3-11
Retrospective and Prospective View of Endotoxin Research....Pages 13-34
Front Matter....Pages 35-35
Beneficially Active Structural Entities in Endotoxin Preparations....Pages 37-55
The Antigenic Structure of the Lipooligosaccharides of Neisseria Gonorrhoeae....Pages 57-64
Lipid A: Relationships of Chemical Structure and Biological Activity....Pages 65-74
Production of Human Monoclonal Antibodies Recognizing Cross-Reactive Determinants on Lipopolysaccharides....Pages 75-81
Physical Properties of Short-Chain and Long-Chain Fractions of Lipopolysaccharide....Pages 83-87
Analysis and Characterization of Bacterial Endotoxins (Lipopolysaccharides) by SDS-Polyacrylamide Gel Electrophoresis Followed by Silver Stain....Pages 89-96
Front Matter....Pages 97-97
Metabolic Effects of Endotoxin....Pages 99-110
Glucose Dyshomeostasis in Endotoxicosis Direct Versus Monokine-Mediated Mechanisms of Endotoxin Action....Pages 111-132
In Vivo Effects on Cellular Metabolism and Calcium Dynamics by Continuous Infusion of Endotoxin....Pages 133-149
Endotoxin (LPS) Toxicity to Hepatocytes (H) In Vitro - Modulation by Macrophages (M)....Pages 151-158
Effects of Endotoxin on Mixed Function Oxidase Activity....Pages 159-169
Myocardial Performance and Adrenergic Modulation of Cyclic AMP Following Endotoxin Administration....Pages 171-185
Cyclic Nucleotides in the Immunopharmacology of Lipopolysaccharide Endotoxins....Pages 187-198
Front Matter....Pages 199-199
Nonspecific Effects of LPS on Bacterial Infections....Pages 201-213
Bacteroides Species Increases Lipopolysaccharide Susceptibility of Experimental Animals....Pages 215-219
The Role of Post-Endotoxin Serum Components from BCG Infected Mice in the Protection of Compromised Hosts....Pages 221-231
Protection Against Lethal Haemophilus Pleuropneumonie Infection in Swine by Antibodies to LPS Core Antigens....Pages 233-237
Salmonella Antigens as Protective Immunogens in Salmonella Infection....Pages 239-255
Front Matter....Pages 199-199
Protective Function of Neutrophils During Experimental Endotoxic Shock....Pages 257-263
Active Immunization with E. Coli J5 and its Protective Effects from Endotoxic Shock in Calves....Pages 265-268
Clinical Recognition and Treatment of Endotoxinemia....Pages 269-279
Transient Suppression of Yeast Phagocytosis Induced by Legionella Pneumophila in Cultures of Murine Resident Peritoneal Macrophages....Pages 281-290
The Effect of Endotoxin on Migration Inhibitory Factor and Interferon....Pages 291-297
Front Matter....Pages 299-299
Regulation of the Cell Cycle of Murine B Lymphocytes by Lipopolysaccharides....Pages 301-304
Synergistic Effect of Endotoxin with Concanavalin a on DNA Synthesis in Lymphocytes and the Role of Interleukins 1 and 2....Pages 305-314
Biochemical, Immunological and Functional Analysis of Lymphocytes from the LPS-Non-Responder C3H/HeJ Mouse....Pages 315-327
Effects of Endogenous Gut LPS on Cells of the Secretory Immune System....Pages 329-338
Molecular Mechanisms in Lymphokine-Induced Macrophage Activation-Enhanced Production of Oxygen Radicals....Pages 339-351
Induction of Gamma Interferon by Endotoxin in “Aged” Murine Splenocyte Cultures....Pages 353-358
Characterization and Localization of Lipopolysaccharides Following the Ingestion of E. Coli by Murine Macrophages in Vitro....Pages 359-367
The Release of Immunopotentiating Mediators from Macrophages Activated by Endotoxins....Pages 369-379
Changes in Macrophage Progenitor Cell Composition in the Bone Marrow of “Early Phase” Endotoxin-Tolerized Mice....Pages 381-389
Production of Colony-Stimulating Factor (CSF) by Bone Marrow Cells Stimulated with Lipopolysaccharide (LPS) and Phorbol Esters....Pages 391-404
Front Matter....Pages 405-405
Modulation of Humoral and Cell-Mediated Immune Responses by a Structurally Established Nontoxic Lipid A....Pages 407-420
Endotoxin Membrane Protein Complexes as Immunomodulators....Pages 421-433
Endotoxin Associated Proteins and Their Polyclonal and Adjuvant Activities....Pages 435-447
Lipopolysaccharide-Induced Recurrence of Arthritis Initiated by Peptidoglycan-Polysaccharide....Pages 449-454
Antibiotics, Immunity, and Immunoenhancement....Pages 455-458
Front Matter....Pages 405-405
The Effect of Selected Antibiotics on the Endogenous Intestinal Microflora and its Consequences for Experimental Tumor Growth in BALB/C Mice....Pages 459-463
Restoration of Antibody Responsiveness by Endotoxin in Retrovirus-Immunodepressed Mice: Role of Macrophages....Pages 465-478
Endotoxin and Polysaccharide Derivative Induced Enhanced Antibody Formation in Leukemia Virus Infected Mice....Pages 479-490
Clinical Relevance of Endotoxemia....Pages 491-502
Back Matter....Pages 503-518