Illustrated Pathology of the Spleen

Contents......Page 6
Preface......Page 10
Acknowledgements......Page 12
Why is splenectomy performed?......Page 14
Why is splenic pathology perceived to be difficult?......Page 16
What does the surgeon or physician want from the pathologist?......Page 18
What information does the pathologist require?......Page 19
How can fixation and processing be optimized to give the best possible histology?......Page 20
Ancillary investigations......Page 22
Splenic biopsy, fine needle aspiration and laparoscopic splenectomy......Page 23
Implications of splenectomy for the patient......Page 24
References......Page 25
Anatomy and vascular supply......Page 26
Normal micro-anatomy of the spleen......Page 27
Development of the spleen during embryonic and fetal life......Page 30
Functional correlates of red and white pulp structure......Page 32
Abnormalities of splenic function......Page 36
Hyposplenism......Page 37
Hypersplenism......Page 38
An immunohistochemical inventory of the spleen......Page 40
References......Page 44
Speens removed incidentally and those removed following trauma are different......Page 48
An approach to analysis of traumatized or incidental splenectomy specimens......Page 50
Reactive changes in individual compartments of the spleen......Page 53
Spontaneous rupture of the spleen......Page 56
References......Page 57
Introduction......Page 60
Vaccination before splenectomy......Page 61
Sickle cell anaemia and thalassaemias......Page 62
Hereditary spherocytosis and autoimmune blood cell destruction......Page 64
The nature of HS, AIHA and ITP......Page 65
Macroscopic appearances of the spleen in HS, AIHA and ITP......Page 66
Red pulp......Page 67
White pulp......Page 68
Felty’s syndrome......Page 69
Systemic lupus erythematosus......Page 70
References......Page 72
Inherited immunodeficiency syndromes......Page 76
Acquired immunodeficiency due to drugs or irradiation......Page 78
Acquired immunodeficiency syndrome and the spleen......Page 79
Systemic infections involving the spleen in immunocompetent individuals......Page 83
References......Page 87
Introduction......Page 90
B cell small lymphocytic lymphoma/ chronic lymphocytic leukaemia (B-CLL)......Page 91
Mantle cell lymphoma (MCL)......Page 95
Follicle centre cell lymphoma......Page 98
Splenic marginal zone lymphoma......Page 100
Lymphoplasmacytoid lymphoma/ immunocytoma......Page 104
Hairy cell leukaemia......Page 105
Large B cell lymphomas......Page 108
T cell prolymphocytic leukaemia......Page 109
Large granular lymphocyte leukaemia, T cell and NK cell types......Page 110
Hepatosplenic γδT cell lymphoma......Page 113
Hodgkin’s disease......Page 114
Nodular lymphocyte and histiocyte predominant Hodgkin’s disease (nodular L&H HD)......Page 118
References......Page 119
Splenic extramedullary haemopoiesis......Page 124
Systemic mastocytosis......Page 130
Transient abnormal myelopoiesis in association with Trisomy 21 (Down’s syndrome)......Page 134
References......Page 135
Splenic granulomas......Page 138
Storage disorders involving cordal macrophages......Page 139
Langerhans’ cell histiocytosis......Page 149
Splenic pseudotumours and true stromal tumours......Page 150
Peliosis of the spleen......Page 154
Portal hypertension and the spleen......Page 157
Splenic infarction......Page 158
References......Page 160
Appearances and primary origins of metastatic cancers involving the spleen......Page 164
Hamartomas......Page 165
Splenic cysts and false cysts......Page 166
Amyloidosis......Page 167
Congenital anomalies of splenic size, number or anatomical position......Page 168
Splenunculi and splenosis......Page 169
Splenic atrophy and fibrosis......Page 170
Peri-splenitis (‘sugar-icing’ of the spleen)......Page 172
Autolysis in splenic tissue......Page 173
References......Page 174
Reactive spleen or neoplastic lymphoid proliferation?......Page 176
Granulomas and cordal macrophage disorders......Page 186
Extramedullary haemopoiesis – is it significant or not?......Page 189
References......Page 190
A......Page 194
C......Page 195