Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms

Front Matter....Pages 1-1
Physiological Function of Hypoxic Pulmonary Vasoconstriction....Pages 3-14
Hypoxic Pulmonary Vasoconstriction: Heterogeneity....Pages 15-33
The Physics of Hypoxic Pulmonary Hypertension and Its Connection with Gene Actions....Pages 35-50
Front Matter....Pages 51-51
Ca 2+ Sparks in Pulmonary Artery Smooth Muscle Cells: Implications for Hypoxic Pulmonary Vasoconstriction....Pages 53-66
Hypoxia-Mediated Regulation of Ca 2+ Transients in Pulmonary Artery Smooth Muscle Cells....Pages 67-79
Calcium Mobilization by Hypoxia in Pulmonary Artery Smooth Muscle....Pages 81-101
Critical Role of Ca + Sensitization in Acute Hypoxic Pulmonary Vasoconstriction....Pages 103-117
Front Matter....Pages 119-119
Regulation of Ion Channels in Pulmonary Artery Smooth Muscle Cells....Pages 121-134
Regulation of O 2 -Sensitive K + Channels by a Mitochondrial Redox Sensor: Implications for Hypoxic Pulmonary Vasoconstriction....Pages 135-164
Hypoxic Regulation of K + Channel Expression and Function in Pulmonary Artery Smooth Muscle Cells....Pages 165-197
Transient Receptor Potential Channels and Capacitative Ca 2+ Entry in Hypoxic Pulmonary Vasoconstriction....Pages 199-214
Front Matter....Pages 215-215
Endothelium-dependent Hypoxic Pulmonary Vasoconstriction....Pages 217-230
Front Matter....Pages 231-231
Chemistry of Oxygen and Its Derivatives in the Lung....Pages 233-245
Interaction of Oxidants With Pulmonary Vascular Signaling Systems....Pages 247-262
Mitochondrial Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction....Pages 263-275
Redox Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction....Pages 277-291
Mitochondrial Diversity in the Vasculature: Implications for Vascular Oxygen Sensing....Pages 293-311
Hypoxia, Cell Metabolism, and cADPR Accumulation....Pages 313-338
Front Matter....Pages 339-339
Involvement of Intracellular Reactive Oxygen Species in the Control of Gene Expression by Oxygen....Pages 341-360
Oxygen Sensing, Oxygen-sensitive Ion Channels and Mitochondrial Function in Arterial Chemoreceptors....Pages 361-373
Front Matter....Pages 339-339
Oxygen Sensing by Adrenomedullary Chromaffin Cells....Pages 375-388
Oxygen-sensitive Ion Channels in Pheochromocytoma (PC12) Cells....Pages 389-399
Front Matter....Pages 401-401
Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension....Pages 403-418
Rho/Rho-kinase Signaling in Hypoxic Pulmonary Hypertension....Pages 419-435
Hypoxia-sensitive Transcription Factors and Growth Factors....Pages 437-447
Heterogeneity in Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation....Pages 449-469
Persistent Pulmonary Hypertension of the Newborn: Pathophysiology and Treatment....Pages 471-495
Roles for Vasoconstriction and Gene Expression in Hypoxia-induced Pulmonary Vascular Remodeling....Pages 497-510
Polyamine Regulation in Hypoxic Pulmonary Arterial Cells....Pages 511-522
Strain Differences of Hypoxia-Induced Pulmonary Hypertension....Pages 523-541
Front Matter....Pages 543-543
Animal and In Vitro Models for Studying Hypoxic Pulmonary Vasoconstriction....Pages 545-558
Transgenic and Gene-Targeted Mouse Models in Hypoxic Pulmonary Hypertension Research....Pages 559-568
Measurement of Ionic Currents and Intracellular Ca 2+ Using Patch Clamp and Fluorescence Microscopy Techniques....Pages 569-582