Hypotensive Peptides: Proceedings of the International Symposium October 25–29, 1965, Florence, Italy

Front Matter....Pages i-xxvi
Automated Peptide Synthesis....Pages 1-13
Synthesis of All-D-Isomers in the Bradykinin Series....Pages 14-22
The Search for Peptides with Specific Antibradykinin Activity....Pages 23-31
Discussion....Pages 31-33
Recent Developments in the Chemistry of Gastrin....Pages 34-44
The Influence of Substitution or Omission of an Amino Group on the Hypotensive Activity of the C-Terminal Sequences of Eledoisin....Pages 45-54
Novel Techniques for the Synthesis of Linear and Cyclic Peptides....Pages 55-62
Polypeptides Active on Plain Muscle in the Amphibian Skin....Pages 63-75
A Bradykinin-Like Endecapeptide of the Skin of Phyllomedusa Rohdei....Pages 76-85
Synthetic Peptides Related to Physalaemin and Eleodoisin....Pages 86-92
Characterization of Kinins in Wasp Venom....Pages 93-104
Studies of Bovine Plasma Kininogen, Ornitho-Kallikrein, and Ornitho-Kinin....Pages 105-115
Enzymatic Kinin Release from Kininogen and from Low-Molecular Compounds....Pages 116-129
The Purification and Some Properties of Two Different Kallidinogens from Human Plasma....Pages 130-138
Physiological Influence on the Liberation of Human Plasma Kinin at Low Temperatures....Pages 139-148
Purification and Properties of Bradykininogen and of the Bradykinin-Releasing and -Destroying Enzymes in Snake Venom....Pages 149-160
Human Salivary Kallikrein and Liberation of Colostrokinin....Pages 161-174
Studies of the Specificity of Kinin-Forming Enzymes....Pages 175-184
Demonstration of the Presence of Two Separate Kinin-Forming Systems in Human and Other Plasma....Pages 185-197
Quantitative Studies of Kinin-Releasing Enzymes in Plasma....Pages 198-210
Immunologic Studies of Components of the Kallikrein-Kinin System....Pages 211-220
Kininogenases, Kininases, and Their Inhibitors....Pages 221-234
Inactivation and Potentiation of the Effects of Bradykinin....Pages 235-251
The Role of Cathepsins in the Inactivation of Plasma Kinins....Pages 252-262
The Physiological and Pathological Role of the Kallikrein-Kallidin System....Pages 263-274
Kallikrein and Vasodilatation in the Salivary Gland....Pages 275-280
Further Experiments on the Role of Plasma Kinins as Mediators of Functional Vasodilatation in Glandular Tissues....Pages 281-288
Effect of Bradykinin on Submandibular Salivary Gland Permeability....Pages 289-297
A Radio-Immunoassay for Bradykinin....Pages 298-304
Self-Antagonism of Bronchoconstriction Induced by Bradykinin and Angiotensin....Pages 305-313
The Effect of Bradykinin and Angiotensin on Ganglionic Transmission....Pages 314-328
Polypeptide Receptor Mechanisms: Influence of pH....Pages 329-340
Sensitization of Smooth Muscle to the Action of Plasma Kinins by Chymotrypsin....Pages 341-343
Potentiation of the Effect of Bradykinin....Pages 344-355
Bradykinin-Potentiating Factor....Pages 356-367
The Influence of Intra-Arterial Infusions of Synthetic Bradykinin on Flow and Composition of Lymph in Dogs....Pages 368-374
The Action of Hypotensive Polypeptides on the Pulmonary Arterial Pressure....Pages 375-384
Bradykinin and Pulmonary Vascular Permeability in Isolated Blood-Perfused Rabbit Lungs....Pages 385-395
Venoconstriction Induced by Bradykinin in the Rabbit Ear....Pages 396-406
Cardiovascular Actions of Physalaemin....Pages 407-413
Hemodynamic Effects of Physalaemin and of Some Synthetic Eledoisin and Physalaemin-like Polypeptides....Pages 414-429
The Effects of Eledoisin and Bradykinin on the General and Visceral Circulation....Pages 430-440
The Effects of Bradykinin and Substance P on the Specialized Ventricular Conducting System of Dog Heart....Pages 441-450
Microcirculatory Effects of Polypeptides....Pages 451-462
The Proteolytic Process in Pancreatic Disease....Pages 463-473
Kinin Formation and Destruction in Fluid Produced by a Strangulated Segment of Ileum in the Rat....Pages 474-484
Fibrinolysis and Vasoactive Peptides in Anaphylaxis....Pages 485-505
Treatment of Experimental and Human Atherosclerosis with Bradykinin-Antagonist, Pyridinolcarbamate: A Preliminary Report....Pages 506-521
Some Physiological and Pathological Roles of Kininogen and Kinins....Pages 522-535
Bradykininogen in the Blood of Women during Pregnancy, Labor, and Puerperium....Pages 536-544
Pharmacologically Active Peptides in Trypanosome Infections....Pages 545-550
Possible Modes of Kinin Formation in Some Pathological States in Man....Pages 551-564
Biochemical and Physiologic Studies of the Kinins in Carcinoid Syndrome....Pages 565-578
Occurrence of a Polypeptide Biologically not Distinguishable from Bradykinin in Human Pulmonary Carcinoma....Pages 579-582
In Memory of Sir John Gaddum, F.R.S.....Pages 583-583
Purification of Substance P....Pages 584-593
Studies of Substance P....Pages 594-607
Substance P in Lipid Extracts of Brain Tissue....Pages 608-620
The Role of Release of Acetylcholine in the Gut-Contracting Action of a Brain Polypeptide....Pages 621-632
Contribution to the Sedative Action of Substance P....Pages 633-640
The Hypotensive Action of Eledoisin in Subjects with Arterial Hypertension ....Pages 641-642
Remarks....Pages 643-643
Trasylol....Pages 644-645
Concluding Remarks....Pages 646-647
Back Matter....Pages 648-660