Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

Front Matter....Pages i-x
Front Matter....Pages xi-xi
Transcriptional Regulation of the Human Apolipoprotein Genes....Pages 1-23
Mutations and Variants of Apolipoprotein B that Affect Plasma Cholesterol Levels....Pages 25-31
Molecular Genetics of Familial Hypercholesterolemia....Pages 33-37
Investigation of Structural Domains in Human Serum Low Density Lipoprotein Apolipoprotein B100....Pages 39-48
Implications of Thiolester Linked Fatty Acids in Apolipoprotein B....Pages 49-58
Factors Regulating the Distribution of Cholesterol Between LDL and HDL....Pages 59-64
Regulation of Hepatic Lipase Expression by an Intermediate of the Cellular Cholesterol Biosynthetic Pathway....Pages 65-69
Human Plasma Lecithin:Cholesterol Acyltransferase (LCAT) On the role of essential carboxyl groups in catalysis....Pages 71-75
Plasma Lipoprotein Phenotype in Response to Cholesteryl Ester Transfer Protein Levels in Dyslipoproteinemia....Pages 77-80
HDL Receptor-Mediated Cholesterol Efflux from Cells and its Regulattion....Pages 81-83
Binding of Apolipoproteins A to Adipose Cells : Role of Receptor Sites in Cholesterol Efflux and Purification of Binding Protein(S)....Pages 85-92
Lipoprotein A-I Containing Particles....Pages 93-99
Distribution of Cholesterol within High Density Lipoproteins Fractionated by Immunoaffinity Chromatography....Pages 101-107
Metabolic Role of Human Apoprotein A-IV....Pages 109-115
Regression of Atheroma and Putative Role of CETP in Cholesteryl Ester Removal....Pages 117-122
Symmetry of the Surface, and Structure of the Central Core of Human LDL Particles, Analyzed by X-Ray Small Angle Scattering....Pages 123-130
Role of Amphipathic Helixes in HDL Structure/Function....Pages 131-140
Conformational Properties of Apolipoproteins Studied by Computer Graphics....Pages 141-145
Alterations of High Density Lipoproteins Induced by Thyroid Hormones in Man and Rat....Pages 147-154
The Help-System in the Treatment of Severe Hypercholesterolaemia: Acute and Long-Term Experience....Pages 155-159
Front Matter....Pages xi-xi
Familial Hypocholesterolemia and HDL Deficiency....Pages 161-171
Mechanisms of Hypocholesterolemia....Pages 173-182
Origin of Cholesterol and Bile Acids in the Diverted Bile of Two Patients with Total Small Bowel Resection....Pages 183-187
Front Matter....Pages N1-N2
Berman’s Simulation Analysis and Modeling....Pages 189-199
Considerations in Designing and Analyzing Data from Apo-B Turnover Studies....Pages 201-211
What is Meant by Overproduction of Apo B-Containing Lipoproteins?....Pages 213-222
Kinetics of Heterogeneous Populations of Particles....Pages 223-232
HDL Metabolism in HDL Deficiency Associated with Familial Hypertriglyeridemia: Effect of Treatment with Gemfibrozil....Pages 233-236
Recent Advances in Lipoprotein Metabolism and the Genetic Dyslipoproteinemias....Pages 237-244
Kinetic Studies of the Origin of Apolipoprotein (APO) B-100 in Low Density Lipoproteins of Normal and Watanabe Heritable Hyperlipidemic (WHHL) Rabbits....Pages 245-255
Alterations in Cholesterol Metabolism in the Genetically Hyper Cholesterolemic RICO Rat: An Overview....Pages 257-274
Front Matter....Pages N3-N3
Genetic Variation at the Lipoprotein Lipase Gene Associates with Coronary Arteriosclerosis....Pages 275-279
The Lipid Surface of Triglyceride-Rich Particles Can Modulate (Apo)Protein Binding and Tissue Uptake....Pages 281-288
Structure and Metabolism of Low Density Lipoproteins from Normal and Hypertriglyceridemic Subjects....Pages 289-293
The ApoB 100-Apo(a) Complex: Relation to Triglyceride-Rich Particles....Pages 295-298
ApoB-Containing Lipoprotein Particles as Risk Factors for Coronary Artery Disease....Pages 299-309
In Vitro Binding and in Vivo Uptake of Chylomicron Remnants after their Hydrolysis by Hepatic Lipase....Pages 311-317
The Endocytosis of Lipoproteins by the Liver and their Intracellular Pathway in Comparison to other Ligands....Pages 319-324
Concomitant Inhibition of VLDL Triglyceride and Apoprotein Secretion by Hepatocytes of Rats Adapted to a High-Fat Diet....Pages 325-328
Molecular Genetics of ApoC-II and Lipoprotein Lipase Deficiency....Pages 329-333
Front Matter....Pages N3-N3
What Factors Regulate the Action of Lipoprotein Lipase?....Pages 335-339
Front Matter....Pages N5-N5
Cytotoxicity of Remnants of Triglyceride-Rich Lipoproteins: An Atherogenic Insult?....Pages 341-351
The Role of Oxidized LDL in Atherosclerosis....Pages 353-365
Probucol and its Mechanisms for Reducing Atherosclerosis....Pages 367-372
Proteoglycans, Lipoproteins, and Atherosclerosis....Pages 373-381
Immune Mechanisms in the Pathogenesis of Atherosclerosis....Pages 383-392
Cholesterol Level in Circulating Immune Complexes as a Marker of Coronary Atherosclerosis....Pages 393-397
Antibody-Like Immunoglobulins G Against Low Density Lipoprotein that Stimulate LIPID Accumulation in Cultured Cells....Pages 399-405
Nutritional Regulation of Apolipoprotein Genes: Effect of Dietary Carbohydrates and Fatty Acids....Pages 407-416
Lipoprotein Structure and Metabolism During Progression and Regression of Atherosclerosis in Pigs Fed With Fish Oil-Derived Fatty Acids....Pages 417-421
Back Matter....Pages 423-443