Humanized Mice for HIV Research

Front Matter....Pages i-xxi
Mamoru Ito’s Vision for the Future of Humanized Mouse Models....Pages 1-12
Front Matter....Pages 13-13
Humanized Mice as Models for Human Disease....Pages 15-24
Role of Mouse Innate Immunity in Immunodeficient Mice for Xenotransplantation....Pages 25-32
Mouse Genetic Background and Human Hematopoietic Stem Cells Biology; Tips for Humanization....Pages 33-51
Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice....Pages 53-60
Impact of the Mouse IL-2Rγ Chain on Lymphoid Tissue Development and Human Reconstitution in Immunodeficient Mice....Pages 61-73
BM Hematopoietic Niche Occupancy Defect of HSC in Scid Mice....Pages 75-82
Improvement of Human Multilineage Hematopoietic Engraftment by Cytokine Knock-in Replacement in Human‐Hemato‐Lymphoid System Mice....Pages 83-90
Front Matter....Pages 91-91
Cytokine Species-Specificity and Humanized Mice....Pages 93-108
Human T-Cell Biology in a Mouse Environment....Pages 109-125
Thymic Education of Human T Cells and Regulatory T Cell Development in Humanized Mice....Pages 127-140
Human B-Cell Development in a Mouse Environment....Pages 141-152
The Analysis of the Functions of Human B and T Cells in Humanized NOG Mice....Pages 153-159
NK Cell Development in Human Immune System (HIS) Mice and Their Role in HIV Pathogenesis....Pages 161-179
Maintenance and Function of Human CD8 + T Cells and NK Cells in Humanized Mice....Pages 181-192
Phenotypical and Functional Properties of Antigen-Presenting Cells Derived from Humanized Mice....Pages 193-205
Front Matter....Pages 207-207
Humanized Mouse Versus Non-human Primate Models of HIV-1 Infection....Pages 209-221
Host Factor-Mediated Resistance to HIV-1 Infection....Pages 223-234
Vaginal and Rectal HIV Transmission in Humanized Mice....Pages 235-245
Oral HIV-1 Transmission in BLT Humanized Mice....Pages 247-254
Front Matter....Pages 207-207
Selective Infection of CD4 + Memory T Cells....Pages 255-264
Development and Function of Human CD4 + CD25 + FOXP3 + Regulatory T Cells in Humanized Mouse and HIV-1 Infection....Pages 265-274
Role of Toll-Like Receptor (TLR) Signaling in HIV-1-Induced Adaptive Immune Activation....Pages 275-287
Latent HIV-1 Infection of Resting CD4 + T cells: Testing Approaches to Overcome HIV Latency....Pages 289-303
Brain HIV-1 Infection Modeling in Humanized Mice....Pages 305-312
Front Matter....Pages 313-313
Antibody-based Protection Against HIV Infection....Pages 315-324
B-Cell Responses in Humanized Mice: The Glass is Half Full....Pages 325-335
Front Matter....Pages 337-337
Species Similarities and Differences in Pharmacokinetics and Distribution of Antiretroviral Drugs....Pages 339-360
Antiretroviral Treatment Testing in HIV-Infected Humanized Mice....Pages 361-380
Humanized Mice as a Platform for the Development of Long-Acting Nanoformulated Antiretroviral Therapy....Pages 381-396
Targeted Delivery of Aptamers and siRNAs for HIV Prevention and Therapies in Humanized Mice....Pages 397-406
Zinc Finger Nuclease Editing of Hematopoietic Stem Cells as an Anti-HIV Therapy....Pages 407-416
Hematopoietic Progenitor Cell Transduction by a Unique Short Hairpin RNA to Chemokine Receptor 5....Pages 417-427
Cell-Based Approaches for Treating HIV Infection....Pages 429-441
A Conditionally Replicating Human Immunodeficiency Virus in BRG-HIS Mice....Pages 443-454
Front Matter....Pages 455-455
Dual Reconstituted Mice for Hepatotropic Pathogens....Pages 457-467
Dengue Viral Pathogenesis and Immune Responses in Humanized Mice....Pages 469-479
HIV-1 and TB: How Humanized Mice Can Help....Pages 481-492
Epstein–Barr Virus Infection in Humanized Mice....Pages 493-508
HTLV-1 Infection of Humanized NOD/SCID IL2 γc −/− and BALB/c-Rag2 −/− γc −/− Mouse Models....Pages 509-518
Front Matter....Pages 455-455
 Plasmodium Falciparum Parasite Development in Humanized Mice: Liver And Blood Stages....Pages 519-528
Front Matter....Pages 529-529
The Future is NOW for Humanized Mouse Models....Pages 531-534
Back Matter....Pages 535-538